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CHEBI:157684 - lymphostin
| Formula | C16H14N4O3 |
| Net Charge | 0 |
| Average Mass | 310.313 |
| Monoisotopic Mass | 310.10659 |
| SMILES | CO/C=C/C(=O)c1cc2c3c(c(N)cc(NC(C)=O)c3n1)N=C2 |
| InChI | InChI=1S/C16H14N4O3/c1-8(21)19-12-6-10(17)15-14-9(7-18-15)5-11(20-16(12)14)13(22)3-4-23-2/h3-7H,17H2,1-2H3,(H,19,21)/b4-3+ |
| InChIKey | HQPIKMNKCMXJQC-ONEGZZNKSA-N |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Salinispora arenicola CNS-205 (ncbitaxon:391037) | - | PubMed (21815669) | |
| Salinispora pacifica (ncbitaxon:351187) | - | PubMed (21815669) | |
| Salinispora tropica CNB-440 (ncbitaxon:369723) | - | PubMed (21815669) | |
| Streptomyces sp. (ncbitaxon:1931) | - | PubMed (9711243) | Strain: KY11783 |
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). marine metabolite Any metabolite produced during a metabolic reaction in marine macro- and microorganisms. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| Application: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| lymphostin (CHEBI:157684) has role bacterial metabolite (CHEBI:76969) |
| lymphostin (CHEBI:157684) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914) |
| lymphostin (CHEBI:157684) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) |
| lymphostin (CHEBI:157684) has role immunosuppressive agent (CHEBI:35705) |
| lymphostin (CHEBI:157684) has role marine metabolite (CHEBI:76507) |
| lymphostin (CHEBI:157684) is a acetamides (CHEBI:22160) |
| lymphostin (CHEBI:157684) is a alkaloid (CHEBI:22315) |
| lymphostin (CHEBI:157684) is a enol ether (CHEBI:47985) |
| lymphostin (CHEBI:157684) is a enone (CHEBI:51689) |
| lymphostin (CHEBI:157684) is a primary arylamine (CHEBI:50471) |
| lymphostin (CHEBI:157684) is a pyrroloquinoline (CHEBI:50918) |
| IUPAC Name |
|---|
| N-{8-amino-4-[(2E)-3-methoxyprop-2-enoyl]pyrrolo[4,3,2-de]quinolin-6-yl}acetamide |
| Synonyms | Source |
|---|---|
| LK6-A | SUBMITTER |
| LK 6A | KNApSAcK |
| Manual Xrefs | Databases |
|---|---|
| C00016344 | KNApSAcK |
| Registry Numbers | Sources |
|---|---|
| CAS:191474-39-2 | KNApSAcK |
| Citations |
|---|