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CHEBI:157684 - lymphostin
| Formula | C16H14N4O3 |
| Net Charge | 0 |
| Average Mass | 310.313 |
| Monoisotopic Mass | 310.10659 |
| SMILES | CO/C=C/C(=O)c1cc2c3c(c(N)cc(NC(C)=O)c3n1)N=C2 |
| InChI | InChI=1S/C16H14N4O3/c1-8(21)19-12-6-10(17)15-14-9(7-18-15)5-11(20-16(12)14)13(22)3-4-23-2/h3-7H,17H2,1-2H3,(H,19,21)/b4-3+ |
| InChIKey | HQPIKMNKCMXJQC-ONEGZZNKSA-N |
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Streptomyces sp. (ncbitaxon:1931) | - | PubMed (9711243) | Strain: KY11783 |
| Salinispora tropica CNB-440 (ncbitaxon:369723) | - | PubMed (21815669) | |
| Salinispora arenicola CNS-205 (ncbitaxon:391037) | - | PubMed (21815669) | |
| Salinispora pacifica (ncbitaxon:351187) | - | PubMed (21815669) |
| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2). marine metabolite Any metabolite produced during a metabolic reaction in marine macro- and microorganisms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol. bacterial metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. |
| Application: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| lymphostin (CHEBI:157684) has role bacterial metabolite (CHEBI:76969) |
| lymphostin (CHEBI:157684) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914) |
| lymphostin (CHEBI:157684) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617) |
| lymphostin (CHEBI:157684) has role immunosuppressive agent (CHEBI:35705) |
| lymphostin (CHEBI:157684) has role marine metabolite (CHEBI:76507) |
| lymphostin (CHEBI:157684) is a acetamides (CHEBI:22160) |
| lymphostin (CHEBI:157684) is a alkaloid (CHEBI:22315) |
| lymphostin (CHEBI:157684) is a enol ether (CHEBI:47985) |
| lymphostin (CHEBI:157684) is a enone (CHEBI:51689) |
| lymphostin (CHEBI:157684) is a primary arylamine (CHEBI:50471) |
| lymphostin (CHEBI:157684) is a pyrroloquinoline (CHEBI:50918) |
| IUPAC Name |
|---|
| N-{8-amino-4-[(2E)-3-methoxyprop-2-enoyl]pyrrolo[4,3,2-de]quinolin-6-yl}acetamide |
| Synonyms | Source |
|---|---|
| LK6-A | SUBMITTER |
| LK 6A | KNApSAcK |
| Manual Xrefs | Databases |
|---|---|
| C00016344 | KNApSAcK |
| Registry Numbers | Sources |
|---|---|
| CAS:191474-39-2 | KNApSAcK |
| Citations |
|---|