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CHEBI:156497 - novolactone

ChEBI IDCHEBI:156497
ChEBI Namenovolactone
Stars
DefinitionA natural product isolated from a fungal strain closely related to Aporospora terricola. It is an allosteric inhibitor of Hsp70.
Last Modified15 September 2020
SubmitterMicheal Alexander
DownloadsMolfile
FormulaC20H28O4
Net Charge0
Average Mass332.440
Monoisotopic Mass332.19876
SMILES[H][C@]12CC=C(C=C)[C@H](C)[C@]1([H])C[C@@H](O)[C@]1(O)[C@]2(C)CC[C@]2([H])OC(=O)[C@]12C
InChIInChI=1S/C20H28O4/c1-5-12-6-7-14-13(11(12)2)10-15(21)20(23)18(14,3)9-8-16-19(20,4)17(22)24-16/h5-6,11,13-16,21,23H,1,7-10H2,2-4H3/t11-,13-,14-,15+,16-,18+,19+,20-/m0/s1
InChIKeyGPFXZYJYVUTNSE-LCPICFLISA-N
Species of MetaboliteComponentSourceComments
Aporospora terricola (ncbitaxon:73565) - PubMed (25544045)
Roles Classification
Biological Roles:
fungal metabolite  Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor  An EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor that interferes with the action of a non-chaperonin molecular chaperone ATPase (EC 3.6.4.10).
ChEBI Ontology
Outgoing Relation(s)
novolactone (CHEBI:156497) has role EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor (CHEBI:76939)
novolactone (CHEBI:156497) has role fungal metabolite (CHEBI:76946)
novolactone (CHEBI:156497) is a diterpene lactone (CHEBI:49193)
novolactone (CHEBI:156497) is a secondary alcohol (CHEBI:35681)
novolactone (CHEBI:156497) is a tetracyclic diterpenoid (CHEBI:52557)
IUPAC Name 
13-ethenyl-5,6β-dihydroxy-14α-methyl-3β-3,15-epoxypodocarp-12-en-15-one
Synonym  Source
(2aS,2bS,3R,4aS,5R,8aS,8bR,10aS)-6-ethenyl-2b,3-dihydroxy-2a,5,8b-trimethyl-2a,2b,3,4,4a,5,8,8a,8b,9,10,10a-dodecahydro-2H-phenanthro[2,1-b]oxet-2-oneIUPAC
Citations