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CHEBI:149761 - zolasartan

ChEBI IDCHEBI:149761
ChEBI Namezolasartan
Stars
DefinitionA member of the class of 1-benzofurans that is 3-bromo-1-benzofuran which is substituted by a 2-(1H-tetrazol-5-yl)phenyl group at position 2 and by a (2-butyl-5-carboxy-4-chloro-1H-imidazol-1-yl)methyl group at position 5. It is an angiotensin II receptor type 1 (AT1) antagonist and was in clinical trials for the treatment of hypertension (now discontinued).
Last Modified19 May 2020
SubmitterAdnan
DownloadsMolfile
FormulaC24H20BrClN6O3
Net Charge0
Average Mass555.820
Monoisotopic Mass554.04688
SMILESCCCCc1nc(Cl)c(C(=O)O)n1Cc1ccc2oc(-c3ccccc3-c3nnnn3)c(Br)c2c1
InChIInChI=1S/C24H20BrClN6O3/c1-2-3-8-18-27-22(26)20(24(33)34)32(18)12-13-9-10-17-16(11-13)19(25)21(35-17)14-6-4-5-7-15(14)23-28-30-31-29-23/h4-7,9-11H,2-3,8,12H2,1H3,(H,33,34)(H,28,29,30,31)
InChIKeyFIKYECRHLXONOX-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
angiotensin receptor antagonist  A hormone antagonist that blocks angiotensin receptors.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
angiotensin receptor antagonist  A hormone antagonist that blocks angiotensin receptors.
ChEBI Ontology
Outgoing Relation(s)
zolasartan (CHEBI:149761) has role angiotensin receptor antagonist (CHEBI:61016)
zolasartan (CHEBI:149761) has role antihypertensive agent (CHEBI:35674)
zolasartan (CHEBI:149761) is a 1-benzofurans (CHEBI:38830)
zolasartan (CHEBI:149761) is a biaryl (CHEBI:64459)
zolasartan (CHEBI:149761) is a imidazolyl carboxylic acid (CHEBI:38307)
zolasartan (CHEBI:149761) is a monocarboxylic acid (CHEBI:25384)
zolasartan (CHEBI:149761) is a organobromine compound (CHEBI:37141)
zolasartan (CHEBI:149761) is a organochlorine compound (CHEBI:36683)
zolasartan (CHEBI:149761) is a tetrazoles (CHEBI:35689)
zolasartan (CHEBI:149761) is conjugate acid of zolasartan(2−) (CHEBI:149524)
Incoming Relation(s)
zolasartan(2−) (CHEBI:149524) is conjugate base of zolasartan (CHEBI:149761)
IUPAC Name 
1-({3-bromo-2-[2-(1H-tetrazol-5-yl)phenyl]-1-benzofuran-5-yl}methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid
INNs  Source
zolasartanumWHO MedNet
zolasartánWHO MedNet
zolasartanWHO MedNet
zolasartanWHO MedNet
Synonyms  Source
GR 117289ChemIDplus
GR 117289CChemIDplus
GR117289ChEBI
GR117289CChEBI
GR-117289CChEBI
GR-117289ChEBI
Registry NumbersSources
CAS:145781-32-4ChemIDplus
Citations