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CHEBI:17939 - puromycin

ChEBI IDCHEBI:17939
ChEBI Namepuromycin
Stars
DefinitionAn aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
Secondary ChEBI IDsCHEBI:8641, CHEBI:14970, CHEBI:26402, CHEBI:45182
Last Modified25 February 2016
DownloadsMolfile
FormulaC22H29N7O5
Net Charge0
Average Mass471.518
Monoisotopic Mass471.22302
SMILESCOc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N(C)C)ncnc43)O[C@@H]2CO)cc1
InChIInChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1
InChIKeyRXWNCPJZOCPEPQ-NVWDDTSBSA-N
Wikipedia
Roles Classification
Biological Roles:
protein synthesis inhibitor  A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein.
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor  An EC 3.4.11.* (aminopeptidase) inhibitor that interferes with the action of cytosol alanyl aminopeptidase (EC 3.4.11.14).
antimicrobial agent  A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor  An EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor that interferes with the action of dipeptidyl-peptidase II (EC 3.4.14.2).
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antiinfective agent  A substance used in the prophylaxis or therapy of infectious diseases.
ChEBI Ontology
Outgoing Relation(s)
puromycin (CHEBI:17939) has role antiinfective agent (CHEBI:35441)
puromycin (CHEBI:17939) has role antimicrobial agent (CHEBI:33281)
puromycin (CHEBI:17939) has role antineoplastic agent (CHEBI:35610)
puromycin (CHEBI:17939) has role EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor (CHEBI:76891)
puromycin (CHEBI:17939) has role EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor (CHEBI:76893)
puromycin (CHEBI:17939) has role nucleoside antibiotic (CHEBI:25605)
puromycin (CHEBI:17939) has role protein synthesis inhibitor (CHEBI:48001)
puromycin (CHEBI:17939) is a puromycins (CHEBI:26404)
puromycin (CHEBI:17939) is conjugate base of puromycin(1+) (CHEBI:60255)
Incoming Relation(s)
puromycin 5'-phosphate (CHEBI:26403) has functional parent puromycin (CHEBI:17939)
puromycin(1+) (CHEBI:60255) is conjugate acid of puromycin (CHEBI:17939)
IUPAC Name 
3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine
INNs  Source
puromycineChemIDplus
puromycinumChemIDplus
puromycinChemIDplus
puromicinaChemIDplus
Synonyms  Source
PuromycinKEGG COMPOUND
3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-diemthyladenosineChEBI
9-{3-deoxy-3-[(O-methyl-L-tyrosyl)amino]-β-D-xylofuranosyl}-N,N-dimethyl-9H-purin-6-amineChEBI
(S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosineChemIDplus
3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosineChemIDplus
AchromycinChemIDplus
Manual XrefsDatabases
C01610KEGG COMPOUND
PuromycinWikipedia
DB08437DrugBank
C00001507KNApSAcK
D05653KEGG DRUG
LSM-2788LINCS
Registry NumbersSources
Reaxys:70234Reaxys
CAS:53-79-2KEGG COMPOUND
CAS:53-79-2ChemIDplus
Citations