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CHEBI:149601 - bempedoic acid

Default Structure
ChEBI IDCHEBI:149601
ChEBI Namebempedoic acid
Stars
DefinitionAn α,ω-dicarboxylic acid that is pentadecanedioic acid which is substituted by methyl groups groups at positions 2 and 14, and by a hydroxy group at position 8. It is a drug used for the treatment of high LDL cholesterol, which is sometimes referred to as 'bad cholesterol'.
Last Modified27 April 2020
SubmitterAdnan
DownloadsMolfile
FormulaC19H36O5
Net Charge0
Average Mass344.492
Monoisotopic Mass344.25627
SMILESCC(C)(CCCCCC(O)CCCCCC(C)(C)C(=O)O)C(=O)O
InChIInChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24)
InChIKeyHYHMLYSLQUKXKP-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Role:
EC 2.3.3.8 (ATP citrate synthase) inhibitor  An EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor that interferes with the action of ATP citrate synthase (EC 2.3.3.8).
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
antiatherosclerotic agent  A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antilipemic drug  A substance used to treat hyperlipidemia (an excess of lipids in the blood).
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
anticholesteremic drug  A substance used to lower plasma cholesterol levels.
ChEBI Ontology
Outgoing Relation(s)
bempedoic acid (CHEBI:149601) has role antiatherosclerotic agent (CHEBI:145947)
bempedoic acid (CHEBI:149601) has role anticholesteremic drug (CHEBI:35821)
bempedoic acid (CHEBI:149601) has role antilipemic drug (CHEBI:35679)
bempedoic acid (CHEBI:149601) has role cardiovascular drug (CHEBI:35554)
bempedoic acid (CHEBI:149601) has role EC 2.3.3.8 (ATP citrate synthase) inhibitor (CHEBI:149598)
bempedoic acid (CHEBI:149601) has role hypoglycemic agent (CHEBI:35526)
bempedoic acid (CHEBI:149601) has role prodrug (CHEBI:50266)
bempedoic acid (CHEBI:149601) is a α,ω-dicarboxylic acid (CHEBI:28383)
IUPAC Name 
8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
INNs  Source
acide bempédoïqueWHO MedNet
ácido bempedoicoWHO MedNet
acidum bempedoicumWHO MedNet
bempedoic acidWHO MedNet
Synonyms  Source
ESP 55016ChemIDplus
ESP-55016ChemIDplus
ETC 1002ChemIDplus
ETC-1002ChemIDplus
ETC1002ChemIDplus
Brand Names  Source
Bempedoic acid component of nexlizetChEMBL
NexletolKEGG DRUG
NilemdoChEMBL
Manual XrefsDatabases
Bempedoic_acidWikipedia
D10691KEGG DRUG
DB11936DrugBank
Registry NumbersSources
CAS:738606-46-7ChemIDplus
Citations