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CHEBI:147411 - TDZD-8

ChEBI IDCHEBI:147411
ChEBI NameTDZD-8
Stars
DefinitionA member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3β (GSK3β). An experimental compound which was being developed for the potential treatment of Alzheimer's disease.
Last Modified7 April 2020
SubmitterKalpana P
DownloadsMolfile
FormulaC10H10N2O2S
Net Charge0
Average Mass222.269
Monoisotopic Mass222.04630
SMILESCn1sc(=O)n(Cc2ccccc2)c1=O
InChIInChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
InChIKeyJDSJDASOXWCHPN-UHFFFAOYSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.11.26 (tau-protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
Applications:
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ChEBI Ontology
Outgoing Relation(s)
TDZD-8 (CHEBI:147411) has role anti-inflammatory agent (CHEBI:67079)
TDZD-8 (CHEBI:147411) has role antineoplastic agent (CHEBI:35610)
TDZD-8 (CHEBI:147411) has role apoptosis inducer (CHEBI:68495)
TDZD-8 (CHEBI:147411) has role EC 2.7.11.26 (tau-protein kinase) inhibitor (CHEBI:91092)
TDZD-8 (CHEBI:147411) has role neuroprotective agent (CHEBI:63726)
TDZD-8 (CHEBI:147411) is a benzenes (CHEBI:22712)
TDZD-8 (CHEBI:147411) is a thiadiazolidine (CHEBI:48865)
IUPAC Name 
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
Synonyms  Source
thiadiazolidinone-8ChEBI
NP 01139ChEBI
Manual XrefsDatabases
NZ574619Patent
Registry NumbersSources
CAS:327036-89-5SUBMITTER
Citations