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CHEBI:147398 - tideglusib

ChEBI IDCHEBI:147398
ChEBI Nametideglusib
Stars
DefinitionA member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3β (GSK3β) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.
Last Modified7 April 2020
SubmitterKalpana P
DownloadsMolfile
FormulaC19H14N2O2S
Net Charge0
Average Mass334.400
Monoisotopic Mass334.07760
SMILESO=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
InChIInChI=1S/C19H14N2O2S/c22-18-20(13-14-7-2-1-3-8-14)19(23)24-21(18)17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2
InChIKeyPMJIHLSCWIDGMD-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 2.7.11.26 (tau-protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of tau-protein kinase inhibitor (EC 2.7.11.26).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Applications:
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
ChEBI Ontology
Outgoing Relation(s)
tideglusib (CHEBI:147398) has role anti-inflammatory agent (CHEBI:67079)
tideglusib (CHEBI:147398) has role apoptosis inducer (CHEBI:68495)
tideglusib (CHEBI:147398) has role EC 2.7.11.26 (tau-protein kinase) inhibitor (CHEBI:91092)
tideglusib (CHEBI:147398) has role neuroprotective agent (CHEBI:63726)
tideglusib (CHEBI:147398) is a benzenes (CHEBI:22712)
tideglusib (CHEBI:147398) is a naphthalenes (CHEBI:25477)
tideglusib (CHEBI:147398) is a thiadiazolidine (CHEBI:48865)
IUPAC Name 
4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione
INNs  Source
tideglusibWHO MedNet
tideglusibWHO MedNet
tideglusibumWHO MedNet
tidéglusibWHO MedNet
Synonyms  Source
NP-031112DrugBank
NP031112DrugBank
NP-12DrugBank
NP 031112ChemIDplus
Brand Names  Source
ZentylorChEBI
NyptaChEBI
Manual XrefsDatabases
DB12129DrugBank
TideglusibWikipedia
Registry NumbersSources
CAS:865854-05-3ChemIDplus
Citations