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CHEBI:145537 - AMG-925

ChEBI IDCHEBI:145537
ChEBI NameAMG-925
Stars
DefinitionAn organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML).
Last Modified28 November 2019
SubmitterAdnan
DownloadsMolfile
FormulaC26H29N7O2
Net Charge0
Average Mass471.565
Monoisotopic Mass471.23827
SMILESC[C@H]1CC[C@H](n2c3cnccc3c3cnc(Nc4ccc5c(n4)CCN(C(=O)CO)C5)nc32)CC1
InChIInChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)/t16-,18-
InChIKeyBBUVDDPUURMFOX-SAABIXHNSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
AMG-925 (CHEBI:145537) has role antineoplastic agent (CHEBI:35610)
AMG-925 (CHEBI:145537) has role apoptosis inducer (CHEBI:68495)
AMG-925 (CHEBI:145537) has role EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
AMG-925 (CHEBI:145537) has role EC 2.7.11.22 (cyclin-dependent kinase) inhibitor (CHEBI:82665)
AMG-925 (CHEBI:145537) is a naphthyridine derivative (CHEBI:73539)
AMG-925 (CHEBI:145537) is a organic heterotricyclic compound (CHEBI:26979)
AMG-925 (CHEBI:145537) is a primary α-hydroxy ketone (CHEBI:139590)
AMG-925 (CHEBI:145537) is a secondary amino compound (CHEBI:50995)
AMG-925 (CHEBI:145537) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
2-hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone
Synonyms  Source
AMG 925ChEBI
FLX925ChEBI
AMG-925ChEBI
2-hydroxy-1-[2-({9-[(1r,4r)-4-methylcyclohexyl]-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethan-1-oneIUPAC
FLX-925ChEBI
FLX 925ChEBI
Manual XrefsDatabases
US8623885Patent
Registry NumbersSources
CAS:1401033-86-0ChemIDplus
Citations