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CHEBI:145431 - indisulam

ChEBI IDCHEBI:145431
ChEBI Nameindisulam
Stars
DefinitionA chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.
Last Modified15 April 2021
SubmitterAdnan
DownloadsMolfile
FormulaC14H12ClN3O4S2
Net Charge0
Average Mass385.854
Monoisotopic Mass384.99578
SMILESNS(=O)(=O)c1ccc(S(=O)(=O)Nc2cccc3c(Cl)cnc23)cc1
InChIInChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChIKeySETFNECMODOHTO-UHFFFAOYSA-N
Roles Classification
Biological Role:
EC 4.2.1.1 (carbonic anhydrase) inhibitor  An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
indisulam (CHEBI:145431) has role antineoplastic agent (CHEBI:35610)
indisulam (CHEBI:145431) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
indisulam (CHEBI:145431) is a chloroindole (CHEBI:52508)
indisulam (CHEBI:145431) is a organochlorine compound (CHEBI:36683)
indisulam (CHEBI:145431) is a sulfonamide (CHEBI:35358)
IUPAC Name 
N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide
INNs  Source
indisulamWHO MedNet
indisulamWHO MedNet
indisulamumWHO MedNet
indisulamWHO MedNet
Synonyms  Source
E-7070DrugBank
E7070DrugBank
N1-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamideIUPAC
N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamideChEBI
Manual XrefsDatabases
DB06370DrugBank
D04522KEGG DRUG
EF6PDBeChem
Registry NumbersSources
CAS:165668-41-7ChemIDplus
Citations