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CHEBI:144677 - SB-284851-BT

ChEBI IDCHEBI:144677
ChEBI NameSB-284851-BT
Stars
DefinitionA piperidinylimidazole that is 1H-imidazole carrying a piperidin-4-yl group, 4-fluorophenyl group and a 2-(3,5-dimethylphenoxy)pyrimidin-4-yl group at positions 1, 4 and 5 respectively. It is a potent inhibitor of p38α mitogen-activated protein kinase and BRD4.
Last Modified29 August 2019
Submitteralison.axtman
DownloadsMolfile
FormulaC26H26FN5O
Net Charge0
Average Mass443.526
Monoisotopic Mass443.21214
SMILESCc1cc(C)cc(Oc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)c1
InChIInChI=1S/C26H26FN5O/c1-17-13-18(2)15-22(14-17)33-26-29-12-9-23(31-26)25-24(19-3-5-20(27)6-4-19)30-16-32(25)21-7-10-28-11-8-21/h3-6,9,12-16,21,28H,7-8,10-11H2,1-2H3
InChIKeyUVLWMBRFRAMDOW-UHFFFAOYSA-N
Roles Classification
Biological Roles:
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC 2.7.11.24).
bromodomain-containing protein 4 inhibitor  Any inhibitor of bromodomain-containing protein 4 (BRD4).
ChEBI Ontology
Outgoing Relation(s)
SB-284851-BT (CHEBI:144677) has role bromodomain-containing protein 4 inhibitor (CHEBI:137114)
SB-284851-BT (CHEBI:144677) has role EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
SB-284851-BT (CHEBI:144677) is a aryloxypyrimidine (CHEBI:48535)
SB-284851-BT (CHEBI:144677) is a monofluorobenzenes (CHEBI:83575)
SB-284851-BT (CHEBI:144677) is a piperidinylimidazole (CHEBI:48587)
IUPAC Name 
2-(3,5-dimethylphenoxy)-4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]pyrimidine
Synonyms  Source
2-(3,5-dimethylphenoxy)-4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]pyrimidineChEBI
SB-284851-BTChEBI
SB-284851ChEBI
SB284851BTChEBI
Citations