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CHEBI:143121 - GW296115X

ChEBI IDCHEBI:143121
ChEBI NameGW296115X
Stars
DefinitionAn indolocarbazole compound having methoxy groups at positions 3 and 9 and an additional fused pyrrolidine-2,5-dione ring. It is an inhibitor of BRSK2 kinase, PDGF-dependent receptor autophosphorylation and cell proliferation.
Last Modified7 March 2019
SubmitterTim Willson
DownloadsMolfile
FormulaC22H15N3O4
Net Charge0
Average Mass385.379
Monoisotopic Mass385.10626
SMILESCOc1ccc2nc3c4nc5ccc(OC)cc5c4c4c(c3c2c1)C(=O)NC4=O
InChIInChI=1S/C22H15N3O4/c1-28-9-3-5-13-11(7-9)15-17-18(22(27)25-21(17)26)16-12-8-10(29-2)4-6-14(12)24-20(16)19(15)23-13/h3-8,23-24H,1-2H3,(H,25,26,27)
InChIKeyLGTURXDQKJRHSF-UHFFFAOYSA-N
Roles Classification
Biological Role:
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
ChEBI Ontology
Outgoing Relation(s)
GW296115X (CHEBI:143121) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
GW296115X (CHEBI:143121) is a aromatic ether (CHEBI:35618)
GW296115X (CHEBI:143121) is a indolocarbazole (CHEBI:51915)
GW296115X (CHEBI:143121) is a organic heterohexacyclic compound (CHEBI:51914)
IUPAC Name 
3,9-dimethoxy-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione
Synonyms  Source
12,13-dihydro-3,9-dimethoxy-5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dioneChEBI
3744WChEBI
GW296115XChEBI
3744-WChEBI
GW296115ChEBI
Registry NumbersSources
CAS:118458-58-5ChEBI
Citations