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CHEBI:143120 - 2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine

ChEBI IDCHEBI:143120
ChEBI Name2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine
Stars
ASCII Name2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine
DefinitionA member of the class of quinazolines that is quinazoline which is substituted at positions 2 and 4 by 6-methylpyridin-2-yl and pyridin-4-ylnitrilo groups, respectively. It is an ALK5 and PKN3 kinase inhibitor.
Last Modified12 March 2019
SubmitterTim Willson
DownloadsMolfile
FormulaC19H15N5
Net Charge0
Average Mass313.364
Monoisotopic Mass313.13275
SMILESCc1cccc(-c2nc(Nc3ccncc3)c3ccccc3n2)n1
InChIInChI=1S/C19H15N5/c1-13-5-4-8-17(21-13)19-23-16-7-3-2-6-15(16)18(24-19)22-14-9-11-20-12-10-14/h2-12H,1H3,(H,20,22,23,24)
InChIKeyJONFDFIXMPXTRH-UHFFFAOYSA-N
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
EC 2.7.11.13 (protein kinase C) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13).
EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the activity of receptor protein serine/threonine kinase (EC 2.7.11.30).
ChEBI Ontology
Outgoing Relation(s)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) has role EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor (CHEBI:137123)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a aromatic amine (CHEBI:33860)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a methylpyridines (CHEBI:25340)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a pyridines (CHEBI:26421)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a quinazolines (CHEBI:38530)
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine (CHEBI:143120) is a secondary amino compound (CHEBI:50995)
IUPAC Name 
2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine
Synonym  Source
GW855857ChEBI
Manual XrefsDatabases
855PDBeChem
DB07267DrugBank
Citations