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CHEBI:143116 - BI00036838

ChEBI IDCHEBI:143116
ChEBI NameBI00036838
Stars
DefinitionA member of the class of oxindoles that is 5-acetyl-3-methylidene-1,3-dihydro-2H-indol-2-one in which one of the hydrogens of the methylidene group is substituted by a 2,2-dimethylhydrazinyl group and the other hydrogen is substituted by an ethyl group. It is a DYRK1B kinase inhibitor.
Last Modified21 May 2019
SubmitterTim Willson
DownloadsMolfile
FormulaC15H19N3O2
Net Charge0
Average Mass273.336
Monoisotopic Mass273.14773
SMILESCC/C(NN(C)C)=C1\C(=O)Nc2ccc(C(C)=O)cc21
InChIInChI=1S/C15H19N3O2/c1-5-12(17-18(3)4)14-11-8-10(9(2)19)6-7-13(11)16-15(14)20/h6-8,17H,5H2,1-4H3,(H,16,20)/b14-12+
InChIKeyDVQQRISDKCELNQ-WYMLVPIESA-N
Roles Classification
Biological Role:
EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor  An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of duals specificity kinases acting on Ser/Thr and Tyr residues.
ChEBI Ontology
Outgoing Relation(s)
BI00036838 (CHEBI:143116) has role EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor (CHEBI:88285)
BI00036838 (CHEBI:143116) is a aromatic ketone (CHEBI:76224)
BI00036838 (CHEBI:143116) is a hydrazines (CHEBI:24631)
BI00036838 (CHEBI:143116) is a methyl ketone (CHEBI:51867)
BI00036838 (CHEBI:143116) is a oxindoles (CHEBI:38459)
IUPAC Name 
(3E)-5-acetyl-3-[1-(2,2-dimethylhydrazinyl)propylidene]-1,3-dihydro-2H-indol-2-one
Synonym  Source
(E)-5-acetyl-3-(1-(2,2-dimethylhydrazineyl)propylidene)indolin-2-oneChEBI
Manual XrefsDatabases
WO2005087727Patent