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CHEBI:142430 - lificiguat

Default Structure
ChEBI IDCHEBI:142430
ChEBI Namelificiguat
Stars
DefinitionA member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation.
Last Modified25 October 2018
SubmitterBijay
DownloadsMolfile
FormulaC19H16N2O2
Net Charge0
Average Mass304.349
Monoisotopic Mass304.12118
SMILESOCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1
InChIInChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChIKeyOQQVFCKUDYMWGV-UHFFFAOYSA-N
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
soluble guanylate cyclase activator  Any compound that binds to and activates soluble guanylate cyclase (EC 4.6.1.2).
Applications:
vasodilator agent  A drug used to cause dilation of the blood vessels.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
lificiguat (CHEBI:142430) has role antineoplastic agent (CHEBI:35610)
lificiguat (CHEBI:142430) has role apoptosis inducer (CHEBI:68495)
lificiguat (CHEBI:142430) has role platelet aggregation inhibitor (CHEBI:50427)
lificiguat (CHEBI:142430) has role soluble guanylate cyclase activator (CHEBI:76022)
lificiguat (CHEBI:142430) has role vasodilator agent (CHEBI:35620)
lificiguat (CHEBI:142430) is a aromatic primary alcohol (CHEBI:33857)
lificiguat (CHEBI:142430) is a furans (CHEBI:24129)
lificiguat (CHEBI:142430) is a indazoles (CHEBI:38769)
IUPAC Name 
[5-(1-benzyl-1H-indazol-3-yl)-2-furyl]methanol
INNs  Source
lificiguatWHO MedNet
lificiguatWHO MedNet
lificiguatWHO MedNet
lificiguatumWHO MedNet
Synonyms  Source
1-benzyl-3-(5-hydroxymethyl-2-furyl)indazoleChEBI
3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazoleChEBI
YC-1SUBMITTER
Registry NumbersSources
Reaxys:8006642Reaxys
CAS:170632-47-0ChemIDplus
Citations