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CHEBI:141517 - tyloxapol

ChEBI IDCHEBI:141517
ChEBI Nametyloxapol
Stars
DefinitionA polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.
Last Modified8 October 2018
Submittersabrina, zfin
DownloadsMolfile
Formula(C17H26O2)m.2(C2H4O)n.C29H44O2
Net Charge0
Average Mass775.168
Monoisotopic Mass774.57984
SMILES[H]OCCOc1ccc(CC(C)(C)C(C)(C)C)cc1Cc1cc(CC(C)(C)C(C)(C)C)cc(Cc2cc(CC(C)(C)C(C)(C)C)ccc2OCCO[H])c1OCCO[H]
InChIInChI=1S/C50H78O6/c1-45(2,3)48(10,11)32-35-16-18-42(54-23-20-51)38(26-35)30-40-28-37(34-50(14,15)47(7,8)9)29-41(44(40)56-25-22-53)31-39-27-36(17-19-43(39)55-24-21-52)33-49(12,13)46(4,5)6/h16-19,26-29,51-53H,20-25,30-34H2,1-15H3
InChIKeyOCZNOKJDQKWBTM-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
surfactant  A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces.
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
inhibitor  A substance that diminishes the rate of a chemical reaction.
Application:
excipient  A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication.
ChEBI Ontology
Outgoing Relation(s)
tyloxapol (CHEBI:141517) has role apoptosis inducer (CHEBI:68495)
tyloxapol (CHEBI:141517) has role excipient (CHEBI:75324)
tyloxapol (CHEBI:141517) has role inhibitor (CHEBI:35222)
tyloxapol (CHEBI:141517) has role surfactant (CHEBI:35195)
tyloxapol (CHEBI:141517) is a polymer (CHEBI:60027)
INNs  Source
tyloxapolChemIDplus
tyloxapolumChEBI
tyloxapolChemIDplus
tiloxapolChemIDplus
Synonyms  Source
oxyethylated tertiary octylphenol formaldehyde polymerChEBI
tyloxypalChEBI
4-(1,1,2,2-tetramethylbutyl)phenol polyer with formaldehyde and oxiraneChEBI
p-isooctylpolyoxyethylenenphenol formaldehyde polymerChEBI
p-(1,1,3,3-tetramethylbutyl)phenol polymer with ethylene oxide and formaldehydeChemIDplus
Brand Names  Source
SuperinoneChEBI
AlevaireChEBI
Triton A-20ChEBI
Triton WR-1339ChEBI
Manual XrefsDatabases
TyloxapolWikipedia
US2454541Patent
D03261KEGG DRUG
DB06439DrugBank
4738DrugCentral
EP0602702Patent
Registry NumbersSources
CAS:25301-02-4ChemIDplus
Citations