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CHEBI:140936 - 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea

Default Structure
ChEBI IDCHEBI:140936
ChEBI Name1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Stars
DefinitionA member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.
Last Modified5 June 2018
SubmitterCeri
DownloadsMolfile
FormulaC14H14N4OS
Net Charge0
Average Mass286.360
Monoisotopic Mass286.08883
SMILESCc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)sn1
InChIInChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
InChIKeyUSFUFHFQWXDVMH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
receptor modulator  A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
ChEBI Ontology
Outgoing Relation(s)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role receptor modulator (CHEBI:90710)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role serotonergic antagonist (CHEBI:48279)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a 1,2-thiazoles (CHEBI:48902)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a indoles (CHEBI:24828)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a ureas (CHEBI:47857)
IUPAC Name 
1-(1-methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Synonyms  Source
3-(3-methyl-1,2-thiazol-5-yl)-1-(1-methylindol-5-yl)ureaSUBMITTER
N-(1-methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaSUBMITTER
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaChEBI
SB 204741ChEBI
SB-204741ChEBI
SB204741ChEBI
Manual XrefsDatabases
SB-204741Wikipedia
Registry NumbersSources
CAS:152239-46-8SUBMITTER
Citations