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CHEBI:140936 - 1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea

ChEBI IDCHEBI:140936
ChEBI Name1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Stars
DefinitionA member of ther class of ureas that is urea in which a hydrogen attached to one of the nitrogens has been replaced by an N-methylindol-5-yl group, while a hydrogen attached to the other nitrogen has been replaced by a 3-methyl-1,2-thiazol-5-yl group. It is a potent and selective antagonist for the 5-hydroxytryptamine 2B (5-HT2B) receptor.
Last Modified5 June 2018
SubmitterCeri
DownloadsMolfile
FormulaC14H14N4OS
Net Charge0
Average Mass286.360
Monoisotopic Mass286.08883
SMILESCc1cc(NC(=O)Nc2ccc3c(ccn3C)c2)sn1
InChIInChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
InChIKeyUSFUFHFQWXDVMH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
receptor modulator  A drug that acts as an antagonist, agonist, reverse agonist, or in some other fashion when interacting with cellular receptors.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
ChEBI Ontology
Outgoing Relation(s)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role receptor modulator (CHEBI:90710)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) has role serotonergic antagonist (CHEBI:48279)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a 1,2-thiazoles (CHEBI:48902)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a indoles (CHEBI:24828)
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea (CHEBI:140936) is a ureas (CHEBI:47857)
IUPAC Name 
1-(1-methyl-1H-indol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Synonyms  Source
N-(1-methyl-1H-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaSUBMITTER
3-(3-methyl-1,2-thiazol-5-yl)-1-(1-methylindol-5-yl)ureaSUBMITTER
SB 204741ChEBI
SB204741ChEBI
SB-204741ChEBI
N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)ureaChEBI
Manual XrefsDatabases
SB-204741Wikipedia
Registry NumbersSources
CAS:152239-46-8SUBMITTER
Citations