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CHEBI:140909 - cardionogen-1

ChEBI IDCHEBI:140909
ChEBI Namecardionogen-1
Stars
DefinitionA triazolothiadiazole that is [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole which is substituted at positions 3 and 6 by 2-furyl and cyclohexyl groups, respectively. A cardiomyocyte promoter and an inhibitor of Wnt/β-catenin dependent transcriptional activity, it induces cardiac cell formation in murine stem cells and zebrafish embryos, expanding cardiac progenitor cells. A biphasic modulator of cardiogenesis, it can act as either a promotor or inhibitor of heart formation, depending on the stage of treatment.
Last Modified1 June 2018
Submittersabrina, zfin
DownloadsMolfile
FormulaC13H14N4OS
Net Charge0
Average Mass274.349
Monoisotopic Mass274.08883
SMILESc1coc(-c2nnc3sc(C4CCCCC4)nn23)c1
InChIInChI=1S/C13H14N4OS/c1-2-5-9(6-3-1)12-16-17-11(10-7-4-8-18-10)14-15-13(17)19-12/h4,7-9H,1-3,5-6H2
InChIKeySWTUPSNBTSPBIH-UHFFFAOYSA-N
Roles Classification
Biological Role:
Wnt signalling inhibitor  A substance that inhibits any of the Wnt signalling pathway, a group of signal transduction pathways made of proteins that pass signals from outside of a cell through cell surface receptors to the inside of the cell.
ChEBI Ontology
Outgoing Relation(s)
cardionogen-1 (CHEBI:140909) has role Wnt signalling inhibitor (CHEBI:78031)
cardionogen-1 (CHEBI:140909) is a furans (CHEBI:24129)
cardionogen-1 (CHEBI:140909) is a triazolothiadiazole (CHEBI:140920)
IUPAC Name 
6-cyclohexyl-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
Synonyms  Source
6-cyclohexyl-3-furan-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoleChEBI
CDNG1ChEBI
vuc230ChEBI
CDNG-1ChEBI
Manual XrefsDatabases
329824737PubChem Compound
Registry NumbersSources
CAS:577696-37-8SUBMITTER
Citations