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CHEBI:139608 - sepantronium bromide

ChEBI IDCHEBI:139608
ChEBI Namesepantronium bromide
Stars
DefinitionAn organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis.
Last Modified7 February 2018
SubmitterGareth Owen
DownloadsMolfile
FormulaBr.C20H19N4O3
Net Charge0
Average Mass443.301
Monoisotopic Mass442.06405
SMILESCOCCn1c2c([n+](Cc3cnccn3)c1C)C(=O)c1ccccc1C2=O.[Br-]
InChIInChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
InChIKeyQBIYUDDJPRGKNJ-UHFFFAOYSA-M
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
survivin suppressant  An apoptosis inducer that works by selectively inhibiting survivin (BIRC5) gene promoter activity so as to down-regulate survivin, a protein that inhibits apoptosis, so leading to induction of apoptosis.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
sepantronium bromide (CHEBI:139608) has part sepantronium (CHEBI:94552)
sepantronium bromide (CHEBI:139608) has role antineoplastic agent (CHEBI:35610)
sepantronium bromide (CHEBI:139608) has role apoptosis inducer (CHEBI:68495)
sepantronium bromide (CHEBI:139608) has role survivin suppressant (CHEBI:139609)
sepantronium bromide (CHEBI:139608) is a organic bromide salt (CHEBI:48369)
IUPAC Name 
1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
INNs  Source
bromuro de sepantronioWHO MedNet
sepantronii bromidumWHO MedNet
bromure de sépantroniumWHO MedNet
sepantronium bromideWHO MedNet
Synonyms  Source
YM 155ChemIDplus
YM-155ChemIDplus
3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromideIUPAC
Manual XrefsDatabases
D10164KEGG DRUG
EP2127652Patent
US7618992Patent
Registry NumbersSources
CAS:781661-94-7ChemIDplus
Citations