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CHEBI:137693 - rhosin

ChEBI IDCHEBI:137693
ChEBI Namerhosin
Stars
DefinitionA D-tryptophan derivative obtained by formal condensation of the carboxy group of D-tryptophan with the amino group of (quinoxalin-6-yl)methylidenehydrazide. It directly targets the Rho GEF binding domain, thereby preventing Rho from interacting with its GEFs
Last Modified5 September 2017
Submittersabrina, zfin
DownloadsMolfile
FormulaC20H18N6O
Net Charge0
Average Mass358.405
Monoisotopic Mass358.15421
SMILESN[C@H](Cc1cnc2ccccc12)C(=O)N/N=C/c1ccc2nccnc2c1
InChIInChI=1S/C20H18N6O/c21-16(10-14-12-24-17-4-2-1-3-15(14)17)20(27)26-25-11-13-5-6-18-19(9-13)23-8-7-22-18/h1-9,11-12,16,24H,10,21H2,(H,26,27)/b25-11+/t16-/m1/s1
InChIKeyFGYHLIHEFHCMPP-FVWOBLMASA-N
Roles Classification
Biological Roles:
RhoC inhibitor  Any inhibitor that interferes with the action of the protein RhoC.
RhoA inhibitor  Any inhibitor that interferes with the action of the protein RhoA.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
rhosin (CHEBI:137693) has role antineoplastic agent (CHEBI:35610)
rhosin (CHEBI:137693) has role RhoA inhibitor (CHEBI:138380)
rhosin (CHEBI:137693) has role RhoC inhibitor (CHEBI:138381)
rhosin (CHEBI:137693) is a D-tryptophan derivative (CHEBI:47997)
rhosin (CHEBI:137693) is a hydrazone (CHEBI:38532)
rhosin (CHEBI:137693) is a quinoxaline derivative (CHEBI:38771)
IUPAC Name 
(2R)-2-amino-3-(1H-indol-3-yl)-N'-[(E)-(quinoxalin-6-yl)methylidene]propanehydrazide
Synonyms  Source
Rho InhibitorSUBMITTER
D-tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazideChEBI
(quinoxalinylmethylidene-D-tryptophanyl)hydrazideChEBI
Registry NumbersSources
Reaxys:25133391Reaxys
Citations