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CHEBI:135938 - lasofoxifene

ChEBI IDCHEBI:135938
ChEBI Namelasofoxifene
Stars
DefinitionA member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Secondary ChEBI IDCHEBI:41282
Last Modified29 September 2020
DownloadsMolfile
FormulaC28H31NO2
Net Charge0
Average Mass413.561
Monoisotopic Mass413.23548
SMILES[H][C@@]1(c2ccc(OCCN3CCCC3)cc2)c2ccc(O)cc2CC[C@]1([H])c1ccccc1
InChIInChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1
InChIKeyGXESHMAMLJKROZ-IAPPQJPRSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
estrogen receptor antagonist  An antagonist at the estrogen receptor.
estrogen receptor agonist  An agonist at the estrogen receptor.
Applications:
estrogen receptor antagonist  An antagonist at the estrogen receptor.
bone density conservation agent  An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
cardioprotective agent  Any protective agent that is able to prevent damage to the heart.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
lasofoxifene (CHEBI:135938) has role antineoplastic agent (CHEBI:35610)
lasofoxifene (CHEBI:135938) has role bone density conservation agent (CHEBI:50646)
lasofoxifene (CHEBI:135938) has role cardioprotective agent (CHEBI:77307)
lasofoxifene (CHEBI:135938) has role estrogen receptor agonist (CHEBI:63951)
lasofoxifene (CHEBI:135938) has role estrogen receptor antagonist (CHEBI:50792)
lasofoxifene (CHEBI:135938) is a N-alkylpyrrolidine (CHEBI:46775)
lasofoxifene (CHEBI:135938) is a aromatic ether (CHEBI:35618)
lasofoxifene (CHEBI:135938) is a naphthols (CHEBI:25392)
lasofoxifene (CHEBI:135938) is a tetralins (CHEBI:36786)
IUPAC Name 
(5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
INNs  Source
lasofoxifeneWHO MedNet
lasofoxiféneWHO MedNet
lasofoxifenoWHO MedNet
lasofoxifenumWHO MedNet
Synonyms  Source
(−)-cis-(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-olChEBI
CP-336156DrugCentral
CP-336,156ChemIDplus
CP 336156ChemIDplus
(−)-cis-5,6,7,8-tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphtholChemIDplus
Brand Name  Source
OporiaChemIDplus
Manual XrefsDatabases
C3DPDBeChem
4308DrugCentral
DB06202DrugBank
LasofoxifeneWikipedia
Registry NumbersSources
CAS:180916-16-9ChemIDplus
Citations