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CHEBI:135775 - mosapramine

ChEBI IDCHEBI:135775
ChEBI Namemosapramine
Stars
DefinitionA racemate comprising equimolar amounts of (R)- and (S)-mosapramine. It is a second-generation antipsychotic used for the treatment of schizophrenia.
Last Modified14 January 2021
FormulaC28H35ClN4O
Net Charge0
Average Mass479.070
Monoisotopic Mass478.24994
Wikipedia
Roles Classification
Biological Role:
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
Applications:
second generation antipsychotic  Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements.
dopaminergic antagonist  A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
ChEBI Ontology
Outgoing Relation(s)
mosapramine (CHEBI:135775) has part (R)-mosapramine (CHEBI:166971)
mosapramine (CHEBI:135775) has part (S)-mosapramine (CHEBI:166970)
mosapramine (CHEBI:135775) has role dopaminergic antagonist (CHEBI:48561)
mosapramine (CHEBI:135775) has role second generation antipsychotic (CHEBI:65191)
mosapramine (CHEBI:135775) is a racemate (CHEBI:60911)
IUPAC Name 
rac-1'-[3-(3-chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]hexahydro-2H-spiro[imidazo[1,2-a]pyridine-3,4'-piperidin]-2-one
INNs  Source
mosapraminaWHO MedNet
mosapramineWHO MedNet
mosapramineWHO MedNet
mosapraminumWHO MedNet
Synonyms  Source
clospipramineDrugCentral
rac-mosapramineChEBI
(RS)-mosapramineChEBI
(±)-mosapramineChEBI
racemic mosapramineChEBI
Y-516DrugCentral
Manual XrefsDatabases
1847DrugCentral
4107ChemSpider
D08235KEGG DRUG
DB13676DrugBank
MosapramineWikipedia
Registry NumbersSources
CAS:89419-40-9ChemIDplus
Citations