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CHEBI:135076 - setiptiline

ChEBI IDCHEBI:135076
ChEBI Namesetiptiline
Stars
DefinitionA tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan.
Last Modified9 July 2021
DownloadsMolfile
FormulaC19H19N
Net Charge0
Average Mass261.368
Monoisotopic Mass261.15175
SMILESCN1CCC2=C(C1)c1ccccc1Cc1ccccc12
InChIInChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3
InChIKeyGVPIXRLYKVFFMK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
setiptiline (CHEBI:135076) has role serotonergic antagonist (CHEBI:48279)
setiptiline (CHEBI:135076) has role α-adrenergic antagonist (CHEBI:37890)
setiptiline (CHEBI:135076) is a tertiary amino compound (CHEBI:50996)
setiptiline (CHEBI:135076) is a tetracyclic antidepressant (CHEBI:50940)
setiptiline (CHEBI:135076) is conjugate base of setiptiline(1+) (CHEBI:176784)
Incoming Relation(s)
setiptiline(1+) (CHEBI:176784) is conjugate acid of setiptiline (CHEBI:135076)
IUPAC Name 
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
INNs  Source
setiptilineWHO MedNet
setiptilinumWHO MedNet
setiptilinaWHO MedNet
sétiptilineWHO MedNet
Synonyms  Source
teciptillineDrugCentral
Org-8282DrugCentral
MO 8282ChemIDplus
2,3,4,9-tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridineChemIDplus
MO-8282DrugBank
Org 8282DrugBank
Manual XrefsDatabases
2438DrugCentral
DB09304DrugBank
D08511KEGG DRUG
SetiptilineWikipedia
5016ChemSpider
LSM-45982LINCS
CN101851201Patent
US2006039867Patent
Registry NumbersSources
Reaxys:1650422Reaxys
CAS:57262-94-9ChemIDplus
Citations