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CHEBI:135076 - setiptiline

Default Structure
ChEBI IDCHEBI:135076
ChEBI Namesetiptiline
Stars
DefinitionA tetracyclic antidepressant that is 2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine carrying a methyl group at position 2. Its maleate salt is used for the treatment of depression in Japan.
Last Modified9 July 2021
DownloadsMolfile
FormulaC19H19N
Net Charge0
Average Mass261.368
Monoisotopic Mass261.15175
SMILESCN1CCC2=C(C1)c1ccccc1Cc1ccccc12
InChIInChI=1S/C19H19N/c1-20-11-10-18-16-8-4-2-6-14(16)12-15-7-3-5-9-17(15)19(18)13-20/h2-9H,10-13H2,1H3
InChIKeyGVPIXRLYKVFFMK-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Applications:
serotonergic antagonist  Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
antidepressant  Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
ChEBI Ontology
Outgoing Relation(s)
setiptiline (CHEBI:135076) has role serotonergic antagonist (CHEBI:48279)
setiptiline (CHEBI:135076) has role α-adrenergic antagonist (CHEBI:37890)
setiptiline (CHEBI:135076) is a tertiary amino compound (CHEBI:50996)
setiptiline (CHEBI:135076) is a tetracyclic antidepressant (CHEBI:50940)
setiptiline (CHEBI:135076) is conjugate base of setiptiline(1+) (CHEBI:176784)
Incoming Relation(s)
setiptiline(1+) (CHEBI:176784) is conjugate acid of setiptiline (CHEBI:135076)
IUPAC Name 
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
INNs  Source
setiptilinaWHO MedNet
setiptilineWHO MedNet
sétiptilineWHO MedNet
setiptilinumWHO MedNet
Synonyms  Source
2,3,4,9-tetrahydro-2-methyl-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridineChemIDplus
MO 8282ChemIDplus
MO-8282DrugBank
Org 8282DrugBank
Org-8282DrugCentral
teciptillineDrugCentral
Manual XrefsDatabases
2438DrugCentral
5016ChemSpider
CN101851201Patent
D08511KEGG DRUG
DB09304DrugBank
LSM-45982LINCS
SetiptilineWikipedia
US2006039867Patent
Registry NumbersSources
Reaxys:1650422Reaxys
CAS:57262-94-9ChemIDplus
Citations