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CHEBI:134708 - saroglitazar

ChEBI IDCHEBI:134708
ChEBI Namesaroglitazar
Stars
DefinitionA monocarboxylic acid that is (2S)-2-ethoxy-3-(p-ethoxyphenyl)propanoic acid in which one of the methyl hydrogens of the p-ethoxy substituent has been replaced by the nitrogen of 2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrole. An agonist at the subtypes α and γ of the peroxisome proliferator-activated receptor (PPAR) with predominant PPARα activity, it is used in the treatment of type 2 diabetes.
Last Modified20 April 2017
DownloadsMolfile
FormulaC25H29NO4S
Net Charge0
Average Mass439.577
Monoisotopic Mass439.18173
SMILESCCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O
InChIInChI=1S/C25H29NO4S/c1-4-29-24(25(27)28)17-19-6-10-21(11-7-19)30-16-15-26-18(2)5-14-23(26)20-8-12-22(31-3)13-9-20/h5-14,24H,4,15-17H2,1-3H3,(H,27,28)/t24-/m0/s1
InChIKeyMRWFZSLZNUJVQW-DEOSSOPVSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
PPARalpha agonist  A PPAR modulator which activates the peroxisome proliferator-activated receptor-α.
PPARgamma agonist  A PPAR modulator which activates the peroxisome proliferator-activated receptor-γ.
Application:
hypoglycemic agent  A drug which lowers the blood glucose level.
ChEBI Ontology
Outgoing Relation(s)
saroglitazar (CHEBI:134708) has role hypoglycemic agent (CHEBI:35526)
saroglitazar (CHEBI:134708) has role PPARα agonist (CHEBI:70782)
saroglitazar (CHEBI:134708) has role PPARγ agonist (CHEBI:71554)
saroglitazar (CHEBI:134708) is a aromatic ether (CHEBI:35618)
saroglitazar (CHEBI:134708) is a methyl sulfide (CHEBI:86315)
saroglitazar (CHEBI:134708) is a monocarboxylic acid (CHEBI:25384)
saroglitazar (CHEBI:134708) is a pyrroles (CHEBI:26455)
IUPAC Name 
(2S)-2-ethoxy-3-[4-(2-{2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl}ethoxy)phenyl]propanoic acid
INNs  Source
saroglitazarumWHO MedNet
saroglitazarWHO MedNet
saroglitazarWHO MedNet
saroglitazarWHO MedNet
Brand Name  Source
LipaglynDrugCentral
Manual XrefsDatabases
5047DrugCentral
SaroglitazarWikipedia
Registry NumbersSources
Reaxys:11765048Reaxys
CAS:495399-09-2DrugCentral
CAS:495399-09-2ChemIDplus
Citations