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CHEBI:134708 - saroglitazar

Default Structure
ChEBI IDCHEBI:134708
ChEBI Namesaroglitazar
Stars
DefinitionA monocarboxylic acid that is (2S)-2-ethoxy-3-(p-ethoxyphenyl)propanoic acid in which one of the methyl hydrogens of the p-ethoxy substituent has been replaced by the nitrogen of 2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrole. An agonist at the subtypes α and γ of the peroxisome proliferator-activated receptor (PPAR) with predominant PPARα activity, it is used in the treatment of type 2 diabetes.
Last Modified20 April 2017
DownloadsMolfile
FormulaC25H29NO4S
Net Charge0
Average Mass439.577
Monoisotopic Mass439.18173
SMILESCCO[C@@H](Cc1ccc(OCCn2c(C)ccc2-c2ccc(SC)cc2)cc1)C(=O)O
InChIInChI=1S/C25H29NO4S/c1-4-29-24(25(27)28)17-19-6-10-21(11-7-19)30-16-15-26-18(2)5-14-23(26)20-8-12-22(31-3)13-9-20/h5-14,24H,4,15-17H2,1-3H3,(H,27,28)/t24-/m0/s1
InChIKeyMRWFZSLZNUJVQW-DEOSSOPVSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted acid  A molecular entity capable of donating a hydron to an acceptor (Brønsted base).
Biological Roles:
PPARgamma agonist  A PPAR modulator which activates the peroxisome proliferator-activated receptor-γ.
PPARalpha agonist  A PPAR modulator which activates the peroxisome proliferator-activated receptor-α.
Applications:
hypoglycemic agent  A drug which lowers the blood glucose level.
hepatoprotective agent  Any compound that is able to prevent damage to the liver.
renoprotective agent  Any compound that is able to prevent damage to the kidneys.
ChEBI Ontology
Outgoing Relation(s)
saroglitazar (CHEBI:134708) has role hepatoprotective agent (CHEBI:62868)
saroglitazar (CHEBI:134708) has role hypoglycemic agent (CHEBI:35526)
saroglitazar (CHEBI:134708) has role PPARα agonist (CHEBI:70782)
saroglitazar (CHEBI:134708) has role PPARγ agonist (CHEBI:71554)
saroglitazar (CHEBI:134708) has role renoprotective agent (CHEBI:231911)
saroglitazar (CHEBI:134708) is a aromatic ether (CHEBI:35618)
saroglitazar (CHEBI:134708) is a methyl sulfide (CHEBI:86315)
saroglitazar (CHEBI:134708) is a monocarboxylic acid (CHEBI:25384)
saroglitazar (CHEBI:134708) is a pyrroles (CHEBI:26455)
IUPAC Name 
(2S)-2-ethoxy-3-[4-(2-{2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl}ethoxy)phenyl]propanoic acid
INNs  Source
saroglitazarWHO MedNet
saroglitazarWHO MedNet
saroglitazarWHO MedNet
saroglitazarumWHO MedNet
Brand Name  Source
LipaglynDrugCentral
Manual XrefsDatabases
5047DrugCentral
SaroglitazarWikipedia
Registry NumbersSources
Reaxys:11765048Reaxys
CAS:495399-09-2DrugCentral
CAS:495399-09-2ChemIDplus
Citations