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CHEBI:134184 - pateamine

ChEBI IDCHEBI:134184
ChEBI Namepateamine
Stars
DefinitionA marine macrodiolide that is isolated from the sponge Mycale hentscheli and exhibits anticancer and antiviral properties
Last Modified23 October 2024
SubmitterKeeva
DownloadsMolfile
FormulaC31H45N3O4S
Net Charge0
Average Mass555.785
Monoisotopic Mass555.31308
SMILESCC(/C=C/C(C)=C/[C@@H]1Cc2nc(cs2)[C@@H](C)C[C@@H](N)CC(=O)O[C@@H](C)C/C(C)=C/C=C\C(=O)O1)=C\CN(C)C
InChIInChI=1S/C31H45N3O4S/c1-21(13-14-34(6)7)11-12-23(3)16-27-19-29-33-28(20-39-29)24(4)17-26(32)18-31(36)37-25(5)15-22(2)9-8-10-30(35)38-27/h8-13,16,20,24-27H,14-15,17-19,32H2,1-7H3/b10-8-,12-11+,21-13+,22-9+,23-16+/t24-,25-,26+,27+/m0/s1
InChIKeyDSPNTLCJTJBXTD-IRNRRZNASA-N
Species of MetaboliteComponentSourceComments
Apis cerana (ncbitaxon:7461) - MetaboLights (MTBLS379)
Mycale hentscheli (ncbitaxon:659499) - PubMed (24459774)
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
eukaryotic initiation factor 4F inhibitor  Any compound that inihibits the mammalian protein, eukaryotic initiation factor 4F.
antiviral agent  A substance that destroys or inhibits replication of viruses.
marine metabolite  Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
pateamine (CHEBI:134184) has role antineoplastic agent (CHEBI:35610)
pateamine (CHEBI:134184) has role antiviral agent (CHEBI:22587)
pateamine (CHEBI:134184) has role eukaryotic initiation factor 4F inhibitor (CHEBI:137079)
pateamine (CHEBI:134184) has role marine metabolite (CHEBI:76507)
pateamine (CHEBI:134184) is a 1,3-thiazoles (CHEBI:38418)
pateamine (CHEBI:134184) is a macrodiolide (CHEBI:145556)
pateamine (CHEBI:134184) is a olefinic compound (CHEBI:78840)
pateamine (CHEBI:134184) is a primary amino compound (CHEBI:50994)
pateamine (CHEBI:134184) is a tertiary amino compound (CHEBI:50996)
IUPAC Name 
(3S,6Z,8E,11S,15R,17S)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11,17-trimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione
Synonyms  Source
(−)-pateamineChEBI
Pateamine AKEGG COMPOUND
Manual XrefsDatabases
25053851ChemSpider
C19917KEGG COMPOUND
Registry NumbersSources
Reaxys:8094393Reaxys
CAS:139220-18-1KEGG COMPOUND
Citations