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CHEBI:133170 - quininib

ChEBI IDCHEBI:133170
ChEBI Namequininib
Stars
DefinitionA styrylquinoline that is trans-2-styrylquinoline in which the the phenyl group has been substituted at position 2 by a hydroxy group. It is an anti-angiogenic compound that exerts a dose-dependent antagonism of the cysteinyl leukotriene pathway, preferentially antagonising cysteinyl leukotriene receptor 1. The major species at pH 7.3
Last Modified11 September 2016
SubmitterCeri
DownloadsMolfile
FormulaC17H13NO
Net Charge0
Average Mass247.297
Monoisotopic Mass247.09971
SMILESOc1ccccc1/C=C/c1ccc2ccccc2n1
InChIInChI=1S/C17H13NO/c19-17-8-4-2-6-14(17)10-12-15-11-9-13-5-1-3-7-16(13)18-15/h1-12,19H/b12-10+
InChIKeyNXNDEWNGCMCWMA-ZRDIBKRKSA-N
Roles Classification
Application:
angiogenesis inhibitor  An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
ChEBI Ontology
Outgoing Relation(s)
quininib (CHEBI:133170) has functional parent trans-2-styrylquinoline (CHEBI:51072)
quininib (CHEBI:133170) has role angiogenesis inhibitor (CHEBI:48422)
quininib (CHEBI:133170) is a phenols (CHEBI:33853)
quininib (CHEBI:133170) is a styrylquinoline (CHEBI:26800)
quininib (CHEBI:133170) is conjugate base of quininib(1+) (CHEBI:133233)
Incoming Relation(s)
quininib(1+) (CHEBI:133233) is conjugate acid of quininib (CHEBI:133170)
IUPAC Name 
2-[(E)-2-(quinolin-2-yl)vinyl]phenol
Registry NumbersSources
CAS:1379458-56-6SUBMITTER
Citations