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CHEBI:132912 - nebivolol hydrochloride
| ChEBI ID | CHEBI:132912 |
| ChEBI Name | nebivolol hydrochloride |
| Stars | |
| Definition | A racemate consisting of equal amounts of (R,S,S,S)- and (S,R,R,R)-nebivolol hydrochloride. A cardioselective beta-blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure. |
| Last Modified | 3 August 2016 |
| Submitter | Steve |
| Wikipedia |
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| Roles Classification |
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| Biological Role: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. vasodilator agent A drug used to cause dilation of the blood vessels. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| nebivolol hydrochloride (CHEBI:132912) has part (R,S,S,S)-nebivolol hydrochloride (CHEBI:132914) |
| nebivolol hydrochloride (CHEBI:132912) has part (S,R,R,R)-nebivolol hydrochloride (CHEBI:132913) |
| nebivolol hydrochloride (CHEBI:132912) has role antihypertensive agent (CHEBI:35674) |
| nebivolol hydrochloride (CHEBI:132912) has role vasodilator agent (CHEBI:35620) |
| nebivolol hydrochloride (CHEBI:132912) has role β-adrenergic antagonist (CHEBI:35530) |
| nebivolol hydrochloride (CHEBI:132912) is a racemate (CHEBI:60911) |
| Incoming Relation(s) |
| Byvalson (CHEBI:132911) has part nebivolol hydrochloride (CHEBI:132912) |
| IUPAC Name |
|---|
| rac-(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-({(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl}amino)ethan-1-ol hydrochloride |
| Synonyms | Source |
|---|---|
| (1RS,1'RS)-1,1'-((2RS,2'SR)-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl))-2,2'-iminodiethanol hydrochloride | ChemIDplus |
| R-67555 | ChemIDplus |
| R 67555 | ChemIDplus |
| nebivolol monohydrochloride | ChEBI |