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CHEBI:131968 - tyrphostin B42

ChEBI IDCHEBI:131968
ChEBI Nametyrphostin B42
Stars
DefinitionA monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Last Modified27 October 2021
SubmitterCeri
DownloadsMolfile
FormulaC17H14N2O3
Net Charge0
Average Mass294.310
Monoisotopic Mass294.10044
SMILESN#C/C(=C\c1ccc(O)c(O)c1)C(=O)NCc1ccccc1
InChIInChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKeyTUCIOBMMDDOEMM-RIYZIHGNSA-N
Roles Classification
Chemical Role:
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
STAT3 inhibitor  An inhibitor of signal transducer and activator of transcription 3 (STAT3)
Applications:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ChEBI Ontology
Outgoing Relation(s)
tyrphostin B42 (CHEBI:131968) has role anti-inflammatory agent (CHEBI:67079)
tyrphostin B42 (CHEBI:131968) has role antioxidant (CHEBI:22586)
tyrphostin B42 (CHEBI:131968) has role apoptosis inducer (CHEBI:68495)
tyrphostin B42 (CHEBI:131968) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
tyrphostin B42 (CHEBI:131968) has role geroprotector (CHEBI:176497)
tyrphostin B42 (CHEBI:131968) has role STAT3 inhibitor (CHEBI:87183)
tyrphostin B42 (CHEBI:131968) is a catechols (CHEBI:33566)
tyrphostin B42 (CHEBI:131968) is a enamide (CHEBI:51751)
tyrphostin B42 (CHEBI:131968) is a monocarboxylic acid amide (CHEBI:29347)
tyrphostin B42 (CHEBI:131968) is a nitrile (CHEBI:18379)
tyrphostin B42 (CHEBI:131968) is a secondary carboxamide (CHEBI:140325)
IUPAC Name 
(2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Synonyms  Source
AG 490SUBMITTER
AG-490SUBMITTER
AG490SUBMITTER
tyrphostin AG-490ChemIDplus
Manual XrefsDatabases
LSM-42880LINCS
Registry NumbersSources
Reaxys:4323263Reaxys
CAS:133550-30-8ChemIDplus
Citations