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CHEBI:125514 - AT9283

Default Structure
ChEBI IDCHEBI:125514
ChEBI NameAT9283
Stars
DefinitionA member of the class of benzimidazoles that is 1H-benzimidazole substituted by 4-[(cyclopropylcarbamoyl)amino]-1H-pyrazol-3-yl and morpholin-4-ylmethyl groups at positions 2 and 5, respectively. It is a multi-targeted inhibitor of Aurora kinases A and B, along with JAK2/3, primarily evaluated in Phase I/II trials for hematological malignancies and pediatric solid tumors.
Last Modified14 May 2026
DownloadsMolfile
FormulaC19H23N7O2
Net Charge0
Average Mass381.440
Monoisotopic Mass381.19132
SMILESO=C(Nc1cnnc1-c1nc2ccc(CN3CCOCC3)cc2n1)NC1CC1
InChIInChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
InChIKeyLOLPPWBBNUVNQZ-UHFFFAOYSA-N
Roles Classification
Biological Roles:
Aurora kinase inhibitor  Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation).
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor  An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
AT9283 (CHEBI:125514) has role antineoplastic agent (CHEBI:35610)
AT9283 (CHEBI:125514) has role apoptosis inducer (CHEBI:68495)
AT9283 (CHEBI:125514) has role Aurora kinase inhibitor (CHEBI:70770)
AT9283 (CHEBI:125514) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
AT9283 (CHEBI:125514) is a benzimidazoles (CHEBI:22715)
AT9283 (CHEBI:125514) is a cyclopropanes (CHEBI:51454)
AT9283 (CHEBI:125514) is a morpholines (CHEBI:38785)
AT9283 (CHEBI:125514) is a pyrazoles (CHEBI:26410)
AT9283 (CHEBI:125514) is a ureas (CHEBI:47857)
IUPAC Name 
1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea
Synonyms  Source
1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-ureaChEBI
AT 9283ChEBI
AT-9283ChEBI
N-cyclopropyl-N'-[3-[6-(4-morpholinylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]-ureaChEBI
Manual XrefsDatabases
21437042ChemSpider
35RPDBeChem
DB05169DrugBank
HMDB0248690HMDB
LSM-37023LINCS
Registry NumbersSources
CAS:896466-04-9ChEBI
Citations