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CHEBI:10112 - zileuton

Default Structure
ChEBI IDCHEBI:10112
ChEBI Namezileuton
Stars
DefinitionA member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma.
Last Modified27 May 2021
DownloadsMolfile
FormulaC11H12N2O2S
Net Charge0
Average Mass236.296
Monoisotopic Mass236.06195
SMILESCC(c1cc2ccccc2s1)N(O)C(N)=O
InChIInChI=1S/C11H12N2O2S/c1-7(13(15)11(12)14)10-6-8-4-2-3-5-9(8)16-10/h2-7,15H,1H3,(H2,12,14)
InChIKeyMWLSOWXNZPKENC-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor  A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
leukotriene antagonist  A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
ferroptosis inhibitor  Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
antifibrotic agent  Any agent which acts to reduce fibrosis.
anti-anaemic agent  A compound which increases either the number of red cells or the amount of haemoglobin in the blood.
anti-asthmatic agent  Any compound that has anti-asthmatic effects.
leukotriene antagonist  A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
anti-asthmatic drug  A drug used to treat asthma.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
zileuton (CHEBI:10112) has parent hydride 1-benzothiophene (CHEBI:35858)
zileuton (CHEBI:10112) has role anti-anaemic agent (CHEBI:75835)
zileuton (CHEBI:10112) has role anti-asthmatic agent (CHEBI:65023)
zileuton (CHEBI:10112) has role anti-asthmatic drug (CHEBI:49167)
zileuton (CHEBI:10112) has role anti-inflammatory agent (CHEBI:67079)
zileuton (CHEBI:10112) has role antifibrotic agent (CHEBI:233423)
zileuton (CHEBI:10112) has role antineoplastic agent (CHEBI:35610)
zileuton (CHEBI:10112) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964)
zileuton (CHEBI:10112) has role ferroptosis inhibitor (CHEBI:173084)
zileuton (CHEBI:10112) has role leukotriene antagonist (CHEBI:49159)
zileuton (CHEBI:10112) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
zileuton (CHEBI:10112) is a 1-benzothiophenes (CHEBI:38836)
zileuton (CHEBI:10112) is a ureas (CHEBI:47857)
IUPAC Name 
1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea
INNs  Source
zileutonChemIDplus
zileutonWHO MedNet
zileutónWHO MedNet
zileutonumChemIDplus
Synonyms  Source
(±)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyureaChEBI
ABBOTT-64077ChEMBL
N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyureaChEBI
LeutrolChemIDplus
N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyureaChemIDplus
NSC-730712ChEMBL
Brand Names  Source
ZyfloKEGG DRUG
Zyflo crChEMBL
Manual XrefsDatabases
2862DrugCentral
D00414KEGG DRUG
DB00744DrugBank
LSM-5084LINCS
ZileutonWikipedia
Registry NumbersSources
Reaxys:4869674Reaxys
CAS:111406-87-2KEGG DRUG
CAS:111406-87-2ChemIDplus
Citations