CHEBI:101096 - ethoxzolamide

ChEBI IDCHEBI:101096
ChEBI Nameethoxzolamide
Stars
DefinitionA sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.
Last Modified9 January 2024
DownloadsMolfile
FormulaC9H10N2O3S2
Net Charge0
Average Mass258.324
Monoisotopic Mass258.01328
SMILESCCOc1ccc2nc(S(N)(=O)=O)sc2c1
InChIInChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKeyOUZWUKMCLIBBOG-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 4.2.1.1 (carbonic anhydrase) inhibitor  An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Applications:
antiglaucoma drug  Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
ChEBI Ontology
Outgoing Relation(s)
ethoxzolamide (CHEBI:101096) has role antiglaucoma drug (CHEBI:39456)
ethoxzolamide (CHEBI:101096) has role diuretic (CHEBI:35498)
ethoxzolamide (CHEBI:101096) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
ethoxzolamide (CHEBI:101096) is a aromatic ether (CHEBI:35618)
ethoxzolamide (CHEBI:101096) is a benzothiazoles (CHEBI:37947)
ethoxzolamide (CHEBI:101096) is a sulfonamide (CHEBI:35358)
IUPAC Name 
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Synonyms  Source
6-ethoxy-2-benzothiazolesulfonamideChemIDplus
6-ethoxybenzothiazole-2-sulfonamideNIST Chemistry WebBook
6-Ethoxy-benzothiazole-2-sulfonic acid amideChEMBL
ethoxazolamideChEMBL
ethoxyzolamideChemIDplus
ETHOXZOLAMIDEChEMBL
Manual XrefsDatabases
1089DrugCentral
D02441KEGG DRUG
DB00311DrugBank
EthoxzolamideWikipedia
GB795174Patent
LSM-18787LINCS
US2868800Patent
Registry NumbersSources
CAS:452-35-7KEGG DRUG
CAS:452-35-7NIST Chemistry WebBook
CAS:452-35-7ChemIDplus
Citations