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CHEBI:10033 - warfarin
| ChEBI ID | CHEBI:10033 |
| ChEBI Name | warfarin |
| Stars | |
| Definition | A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice. |
| Last Modified | 7 November 2023 |
| Formula | C19H16O4 |
| Net Charge | 0 |
| Average Mass | 308.333 |
| Monoisotopic Mass | 308.10486 |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | anti-obesity agent Any substance which is used to reduce or control weight. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor An EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor that interferes with the action of NAD(P)H dehydrogenase (quinone), EC 1.6.5.2. vitamin K antagonist A class of anticoagulants which act by inhibiting the action of vitamin K. |
| Applications: | antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. hepatoprotective agent Any compound that is able to prevent damage to the liver. hypoglycemic agent A drug which lowers the blood glucose level. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. antipsoriatic A drug used to treat psoriasis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. rodenticide A substance used to destroy rodent pests. anticonvulsant A drug used to prevent seizures or reduce their severity. antifibrotic agent Any agent which acts to reduce fibrosis. antirheumatic drug A drug used to treat rheumatoid arthritis. anticoagulant An agent that prevents blood clotting. anti-inflammatory agent Any compound that has anti-inflammatory effects. antiparkinson drug A drug used in the treatment of Parkinson's disease. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| warfarin (CHEBI:10033) has part (R)-warfarin (CHEBI:87737) |
| warfarin (CHEBI:10033) has part (S)-warfarin (CHEBI:87738) |
| warfarin (CHEBI:10033) has role anti-arrhythmia drug (CHEBI:38070) |
| warfarin (CHEBI:10033) has role anti-inflammatory agent (CHEBI:67079) |
| warfarin (CHEBI:10033) has role anti-obesity agent (CHEBI:74518) |
| warfarin (CHEBI:10033) has role antiatherosclerotic agent (CHEBI:145947) |
| warfarin (CHEBI:10033) has role anticoagulant (CHEBI:50249) |
| warfarin (CHEBI:10033) has role anticonvulsant (CHEBI:35623) |
| warfarin (CHEBI:10033) has role antidepressant (CHEBI:35469) |
| warfarin (CHEBI:10033) has role antiemetic (CHEBI:50919) |
| warfarin (CHEBI:10033) has role antifibrotic agent (CHEBI:233423) |
| warfarin (CHEBI:10033) has role antihypertensive agent (CHEBI:35674) |
| warfarin (CHEBI:10033) has role antineoplastic agent (CHEBI:35610) |
| warfarin (CHEBI:10033) has role antiparkinson drug (CHEBI:48407) |
| warfarin (CHEBI:10033) has role antipsoriatic (CHEBI:50748) |
| warfarin (CHEBI:10033) has role antirheumatic drug (CHEBI:35842) |
| warfarin (CHEBI:10033) has role cardiovascular drug (CHEBI:35554) |
| warfarin (CHEBI:10033) has role dermatologic drug (CHEBI:50177) |
| warfarin (CHEBI:10033) has role EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor (CHEBI:50390) |
| warfarin (CHEBI:10033) has role hepatoprotective agent (CHEBI:62868) |
| warfarin (CHEBI:10033) has role hypoglycemic agent (CHEBI:35526) |
| warfarin (CHEBI:10033) has role immunosuppressive agent (CHEBI:35705) |
| warfarin (CHEBI:10033) has role rodenticide (CHEBI:33288) |
| warfarin (CHEBI:10033) has role vitamin K antagonist (CHEBI:55347) |
| warfarin (CHEBI:10033) is a racemate (CHEBI:60911) |
| warfarin (CHEBI:10033) is conjugate acid of warfarin(1−) (CHEBI:50393) |
| Incoming Relation(s) |
| warfarin(1−) (CHEBI:50393) is conjugate base of warfarin (CHEBI:10033) |
| IUPAC Name |
|---|
| rac-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one |
| INNs | Source |
|---|---|
| warfarin | WHO MedNet |
| warfarina | WHO MedNet |
| warfarine | WHO MedNet |
| warfarinum | WHO MedNet |
| Synonyms | Source |
|---|---|
| 4-hydroxy-3-[(1RS)-3-oxo-1-phenylbutyl]-2H-1-benzopyran-2-one | IUPAC |
| 4-hydroxy-3-[(1RS)-3-oxo-1-phenylbutyl]-2H-chromen-2-one | IUPAC |
| 4-hydroxy-3-[(1RS)-3-oxo-1-phenylbutyl]coumarin | PPDB |
| Coumafene | ChemIDplus |
| rac-1-(4'-hydroxy-3'-coumarinyl)-1-phenyl-3-butanone | ChemIDplus |
| rac-3-(1'-phenyl-2'-acetylethyl)-4-hydroxycoumarin | ChemIDplus |
| Brand Names | Source |
|---|---|
| Brumolin | ChEBI |
| Choice | ChEMBL |
| Kumadu | ChEBI |
| Kumatox | ChEBI |
| Ratron | ChEBI |
| Rodafarin | ChEBI |
| Citations |
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