voriconazole (CHEBI:10023)

CHEBI:10023 - voriconazole

ChEBI ID	CHEBI:10023
ChEBI Name	voriconazole
Stars
Definition	A triazole-based antifungal agent used for the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. It is an inhibitor of cytochrome P450 2C9 (CYP2C9) and CYP3A4.
Secondary ChEBI ID	CHEBI:127308
Last Modified	15 October 2019
Downloads	Molfile

Formula	C16H14F3N5O
Net Charge	0
Average Mass	349.316
Monoisotopic Mass	349.11504
SMILES	C[C@@H](c1ncncc1F)[C@](O)(Cn1cncn1)c1ccc(F)cc1F
InChI	InChI=1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChIKey	BCEHBSKCWLPMDN-MGPLVRAMSA-N

Wikipedia

Roles Classification

antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria.

P450 inhibitor An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.

anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.

antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals.

antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.

ergosterol biosynthesis inhibitor Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.

antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals.

antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.

ergosterol biosynthesis inhibitor Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.

antifungal agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.

antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases.

antileishmanial agent An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.

antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

anti-asthmatic agent Any compound that has anti-asthmatic effects.

antifungal drug Any antifungal agent used to prevent or treat fungal infections in humans or animals.

ChEBI Ontology

Outgoing Relation(s)
	voriconazole (CHEBI:10023) has role anti-asthmatic agent (CHEBI:65023)
	voriconazole (CHEBI:10023) has role anti-HIV agent (CHEBI:64946)
	voriconazole (CHEBI:10023) has role antibacterial agent (CHEBI:33282)
	voriconazole (CHEBI:10023) has role antiinfective agent (CHEBI:35441)
	voriconazole (CHEBI:10023) has role antileishmanial agent (CHEBI:70868)
	voriconazole (CHEBI:10023) has role antineoplastic agent (CHEBI:35610)
	voriconazole (CHEBI:10023) has role P450 inhibitor (CHEBI:50183)
	voriconazole (CHEBI:10023) is a conazole antifungal drug (CHEBI:87071)
	voriconazole (CHEBI:10023) is a difluorobenzene (CHEBI:38582)
	voriconazole (CHEBI:10023) is a pyrimidines (CHEBI:39447)
	voriconazole (CHEBI:10023) is a tertiary alcohol (CHEBI:26878)
	voriconazole (CHEBI:10023) is a triazole antifungal drug (CHEBI:87101)

IUPAC Name
(2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

Synonyms	Source
NSC-759888	ChEMBL
(R-(R,S))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol	ChEBI
UK-109,496	ChEMBL
VCZ	DrugBank
(αR,βS)-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol	ChemIDplus

Brand Names	Source
Vfend	ChEBI
Voriconazole accord	ChEMBL
Voriconazole hikma (previously voriconazole hospira)	ChEMBL

UniProt Name	Source
voriconazole	UniProt

Citations