PDBsum entry 6t3d

Hydrolase

PDB id: 6t3d

Contents

Protein chain

358 a.a.

Ligands

EDO

SO4

Metals

_CL

_ZN ×2

Waters ×340

PDB id:

6t3d

Name:

Hydrolase

Title:

Crystal structure of ampc from e.Coli

Structure:

Beta-lactamase. Chain: a. Synonym: cephalosporinase. Engineered: yes

Source:

Escherichia coli k-12. Organism_taxid: 83333. Gene: ampc, ampa, b4150, jw4111. Expressed in: escherichia coli str. K-12 substr. W3110. Expression_system_taxid: 316407

Resolution:

1.50Å R-factor: 0.159 R-free: 0.178

Authors:

P.A.Lang,T.M.Leissing,C.J.Schofield,J.Brem

Key ref:

p.a.lang et al. (2020). Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase fromEscherichia coli. Biomolecules, 10, . PubMed id: 32545682

Date:

10-Oct-19 Release date: 24-Jun-20

Protein chain

P00811  (AMPC_ECOLI) -  Beta-lactamase from Escherichia coli (strain K12)

Seq: 377 a.a.

Struc: 358 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)

Biomolecules 10: (2020)

PubMed id: 32545682

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C beta-Lactamase fromEscherichia coli.

p.a.lang, a.parkova, t.m.leissing, k.calvopina, r.cain, a.t.d.panduwawala, j.philippe, c.w.g.fishwick, p.trapenciem.g.p.page, c.j.schofield, j.brem.

ABSTRACT

No abstract given.