PDBsum entry 5kpi

Hydrolase

PDB id: 5kpi

Contents

Protein chains

1185 a.a.

PDB id:

5kpi

Name:

Hydrolase

Title:

Mouse native pgp

Structure:

Multidrug resistance protein 1a. Chain: a, b. Synonym: atp-binding cassette sub-family b member 1a,mdr1a,multidrug resistance protein 3,p-glycoprotein 3. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: abcb1a, abcb4, mdr1a, mdr3, pgy-3, pgy3. Expressed in: komagataella pastoris gs115. Expression_system_taxid: 644223

Resolution:

4.01Å R-factor: 0.260 R-free: 0.303

Authors:

D.Xia,L.Esser,F.Zhou

Key ref:

L.Esser et al. (2017). Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. J Biol Chem, 292, 446-461. PubMed id: 27864369 DOI: 10.1074/jbc.M116.755884

Date:

04-Jul-16 Release date: 30-Nov-16

Protein chains

P21447  (MDR1A_MOUSE) -  ATP-dependent translocase ABCB1 from Mus musculus

Seq: 1276 a.a.

Struc: 1185 a.a.

Enzyme reactions

• Enzyme class 1: E.C.7.6.2.1 - P-type phospholipid transporter.
• Reaction: ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2
• Enzyme class 2: E.C.7.6.2.2 - ABC-type xenobiotic transporter.
• Reaction: ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1074/jbc.M116.755884

J Biol Chem 292:446-461 (2017)

PubMed id: 27864369

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity.

L.Esser, F.Zhou, K.M.Pluchino, J.Shiloach, J.Ma, W.K.Tang, C.Gutierrez, A.Zhang, S.Shukla, J.P.Madigan, T.Zhou, P.D.Kwong, S.V.Ambudkar, M.M.Gottesman, D.Xia.

ABSTRACT

No abstract given.