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PDBsum entry 4ycz
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Structural protein
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PDB id
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4ycz
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Contents |
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713 a.a.
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590 a.a.
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195 a.a.
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References listed in PDB file
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Key reference
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Title
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Atomic structure of the y complex of the nuclear pore.
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Authors
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K.Kelley,
K.E.Knockenhauer,
G.Kabachinski,
T.U.Schwartz.
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Ref.
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Nat Struct Biol, 2015,
22,
425-431.
[DOI no: ]
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PubMed id
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Abstract
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The nuclear pore complex (NPC) is the principal gateway for transport into and
out of the nucleus. Selectivity is achieved through the hydrogel-like core of
the NPC. The structural integrity of the NPC depends on ~15 architectural
proteins, which are organized in distinct subcomplexes to form the >40-MDa
ring-like structure. Here we present the 4.1-Å crystal structure of a
heterotetrameric core element ('hub') of the Y complex, the essential NPC
building block, from Myceliophthora thermophila. Using the hub structure
together with known Y-complex fragments, we built the entire ~0.5-MDa Y complex.
Our data reveal that the conserved core of the Y complex has six rather than
seven members. Evolutionarily distant Y-complex assemblies share a conserved
core that is very similar in shape and dimension, thus suggesting that there are
closely related architectural codes for constructing the NPC in all eukaryotes.
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