PDBsum entry 4e0s

Immune system

PDB id: 4e0s

Contents

Protein chains

1552 a.a.

898 a.a.

Ligands

NAG-NAG ×2

FUC-BGC

MAN ×4

Metals

_NA

_CA

PDB id:

4e0s

Name:

Immune system

Title:

Crystal structure of c5b-6

Structure:

Complement c5. Chain: a. Synonym: c3 and pzp-like alpha-2-macroglobulin domain-containing protein 4, complement c5 beta chain, complement c5 alpha chain, c5a anaphylatoxin, complement c5 alpha' chain. Complement component c6. Chain: b

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Resolution:

4.21Å R-factor: 0.221 R-free: 0.278

Authors:

A.E.Aleshin,B.Stec,R.Discipio,R.C.Liddington

Key ref:

A.E.Aleshin et al. (2012). Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex. J Biol Chem, 287, 19642-19652. PubMed id: 22500023

Date:

05-Mar-12 Release date: 18-Apr-12

Protein chain

P01031  (CO5_HUMAN) -  Complement C5 from Homo sapiens

Seq: 1676 a.a.

Struc: 1552 a.a.*

Protein chain

P13671  (CO6_HUMAN) -  Complement component C6 from Homo sapiens

Seq: 934 a.a.

Struc: 898 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

J Biol Chem 287:19642-19652 (2012)

PubMed id: 22500023

Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

A.E.Aleshin, R.G.DiScipio, B.Stec, R.C.Liddington.

ABSTRACT

No abstract given.