PDBsum entry 4asr

Hydrolase

PDB id: 4asr

Contents

Protein chain

598 a.a.

Ligands

ARG-PRO-PRO-GLY

NAG-NAG-BMA-MAN-BMA-MAN

NAG ×2

FLC

Metals

_ZN

Waters ×573

PDB id:

4asr

Name:

Hydrolase

Title:

Crystal structure of ance in complex with thr6-bradykinin

Structure:

Angiotensin-converting enzyme. Chain: a. Fragment: residues 17-614. Synonym: dipeptidyl carboxypeptidase i, kininase ii. Engineered: yes. Bradykinin. Chain: p. Synonym: thr6-bradykinin. Engineered: yes.

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: komagataella pastoris. Expression_system_taxid: 644223. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606

Resolution:

1.90Å R-factor: 0.184 R-free: 0.200

Authors:

M.Akif,G.Masuyer,E.D.Sturrock,R.E.Isaac,K.R.Acharya

Key ref:

M.Akif et al. (2012). Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster. Febs J, 279, 4525-4534. PubMed id: 23082758

Date:

02-May-12 Release date: 31-Oct-12

Protein chain

Q10714  (ACE_DROME) -  Angiotensin-converting enzyme from Drosophila melanogaster

Seq: 615 a.a.

Struc: 598 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.15.1 - peptidyl-dipeptidase A.
• Reaction: Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II.
• Cofactor: Zn(2+)

Febs J 279:4525-4534 (2012)

PubMed id: 23082758

Structural basis of peptide recognition by the angiotensin-1 converting enzyme homologue AnCE from Drosophila melanogaster.

M.Akif, G.Masuyer, R.J.Bingham, E.D.Sturrock, R.E.Isaac, K.R.Acharya.

ABSTRACT

No abstract given.