_EC 3.4.15.1 Peptidyl-dipeptidase A. 49 PDB entries  
EC 3.-.-.- Hydrolases. [20,861 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,815 PDB entries]
EC 3.4.15.- Peptidyl-dipeptidases. [51 PDB entries]
EC 3.4.15.1 Peptidyl-dipeptidase A. [49 PDB entries]    
1j36

Reaction: Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin ii, with increase in vasoconstrictor activity, but no action on angiotensin Ii.
Other name(s): Ace. Angiotensin I-converting enzyme. Carboxycathepsin. Dipeptidyl carboxypeptidase I. Kininase Ii. Peptidase P. Peptidyl dipeptidase I.
Cofactor(s): Zinc.
Comments: Cl(-)-dependent. A glycoprotein that is generally membrane-bound. Active at neutral pH. Only single dipeptides are released from angiotensin I and bradykinin because of the lack of activity on bonds involving proline. Belongs to peptidase family M2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 49 PDB entries in enzyme class E.C.3.4.15.1

  PDB code Protein
1j36
Crystal structure of drosophila ance
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (598 residues)
1j37
Crystal structure of drosophila ance
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (598 residues) CATH domain: Unassigned
1j38
Crystal structure of drosophila ance
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (598 residues) CATH domain: Unassigned
1o86
Crystal structure of human angiotensin converting enzyme in with lisinopril.
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chain: A (575 residues)
1o8a
Crystal structure of human angiotensin converting enzyme (native).
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chain: A (575 residues) CATH domain: Unassigned
1uze
Complex of the anti-hypertensive drug enalaprilat and the human testicular angiotensin i-converting enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: chinese hamster ovary. Expression_system_cell_line: cho.
Chain: A (575 residues) CATH domain: Unassigned
1uzf
Complex of the anti-hypertensive drug captopril an the human testicular angiotensin i-converting enzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: chinese hamster ovary. Expression_system_cell_line: cho.
Chain: A (575 residues) CATH domain: Unassigned
2c6f
Structure of human somatic angiontensin-i converting enzyme n domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
Chains: A, B (612 residues) CATH domain: Unassigned
2c6n
Structure of human somatic angiontensin-i converting enzyme with lisinopril
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: cho-k1.
Chains: A, B (612 residues) CATH domain: Unassigned
2iul
Human tace g13 mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: chinese hamster ovary cells
Chain: A (583 residues) CATH domain: Unassigned
2iux
Human tace mutant g1234
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: chinese hamster ovary cells
Chain: A (577 residues) CATH domain: Unassigned
2oc2
Structure of testis ace with rxpa380
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ace, dcp, dcp1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell: hampster ovary cells.
Chain: A (583 residues) CATH domain: Unassigned
2x8y
Crystal structure of ance
Source: Drosophila melanogaster. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (595 residues) CATH domain: Unassigned
2x8z
Crystal structure of ance-captopril complex
Source: Drosophila melanogaster. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x90
Crystal structure of ance-enalaprilat complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x91
Crystal structure of ance-lisinopril complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (595 residues) CATH domain: Unassigned
2x92
Crystal structure of ance-ramiprilat complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x93
Crystal structure of ance-trandolaprilat complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x94
Crystal structure of ance-perindoprilat complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x95
Crystal structure of ance-lisinopril-tryptophan analogue, lisw-s complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x96
Crystal structure of ance-rxpa380 complex
Source: Drosophila melanogaster. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2x97
Crystal structure of ance-rxp407 complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2xhm
Crystal structure of ance-k26 complex
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (598 residues) CATH domain: Unassigned
2xy9
Human angiotensin converting enzyme in complex with phosphinic tripeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: chinese hamster ovary cells.
Chain: A (581 residues) CATH domain: Unassigned
2xyd
Human angiotenisn converting enzyme n-domain in complex with phosphinic tripeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho k1.
Chains: A, B (607 residues) CATH domain: Unassigned
2ydm
Structural characterization of angiotensin-i converting enzy complex with a selenium analogue of captopril
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testes. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho.
Chain: A (575 residues) CATH domain: Unassigned
3bkk
Tesis ace co-crystal structure with ketone ace inhibitor kaf
Source: Homo sapiens. Human. Gene: ace, dcp, dcp1. Expressed in: cricetulus griseus. Expression_system_cell_line: cho-k1.
Chain: A (586 residues) CATH domain: Unassigned
3bkl
Testis ace co-crystal structure with ketone ace inhibitor ka
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ace, dcp, dcp1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1.
Chain: A (582 residues) CATH domain: Unassigned
3l3n
Testis ace co-crystal structure with novel inhibitor lisw
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ace, dcp, dcp1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029.
Chain: A (575 residues) CATH domain: Unassigned
3nxq
Angiotensin converting enzyme n domain glycsoylation mutant in complex with rxp407
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ace, dcp, dcp1. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary cells
Chains: A, B (607 residues) CATH domain: Unassigned
3zqz
Crystal structure of ance in complex with a selenium analogu captopril
Source: Drosophila melanogaster. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223.
Chain: A (596 residues) CATH domain: Unassigned
4aa1
Crystal structure of ance in complex with angiotensin-ii
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (598 residues) CATH domain: Unassigned
4aa2
Crystal structure of ance in complex with bradykinin potentiating peptide b
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 644223. Synthetic: yes. Gloydius blomhoffi. Organism_taxid: 242054
Chain: A (598 residues) CATH domain: Unassigned
4aph
Human angiotensin-converting enzyme in complex with angioten
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Organism_taxid: 9606
Chain: A (582 residues) CATH domain: Unassigned
4apj
Human angiotensin-converting enzyme in complex with bppb
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Synthetic: yes. Gloydius blomhoffi. Mamushi. Organism_taxid: 242054
Chain: A (581 residues) CATH domain: Unassigned
4asq
Crystal structure of ance in complex with bradykinin
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: komagataella pastoris. Expression_system_taxid: 644223. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (598 residues) CATH domain: Unassigned
4asr
Crystal structure of ance in complex with thr6-bradykinin
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: komagataella pastoris. Expression_system_taxid: 644223. Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chain: A (598 residues) CATH domain: Unassigned
4bxk
Crystal structure of the angiotensin-1 converting enzyme n- domain in complex with a domain-specific inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho-k1
Chains: A, B (607 residues) CATH domain: Unassigned
4bzr
Human testis angiotensin converting enzyme in complex with k
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029
Chain: A (581 residues) CATH domain: Unassigned
4bzs
Human angiotenisn converting enzyme n-domain in complex with k-26
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: ovary cells
Chains: A, B (612 residues) CATH domain: Unassigned
4c2n
Crystal structure of human testis angiotensin-i converting enzyme mutant e403r
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells.
Chain: A (581 residues) CATH domain: Unassigned
4c2o
Crystal structure of human testis angiotensin-i converting enzyme mutant d465t
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells.
Chain: A (586 residues) CATH domain: Unassigned
4c2p
Crystal structure of human testis angiotensin-i converting enzyme mutant r522k in complex with captopril
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells.
Chain: A (582 residues) CATH domain: Unassigned
4c2q
Crystal structure of human testis angiotensin-i converting enzyme mutant r522k
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells.
Chain: A (586 residues) CATH domain: Unassigned
4c2r
Crystal structure of human testis angiotensin-i converting enzyme mutant r522q
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho cells.
Chain: A (584 residues) CATH domain: Unassigned
4ca5
Human angiotensin converting enzyme in complex with a phosphinic tripeptide fi
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: testis. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho
Chain: A (586 residues) CATH domain: Unassigned
4ca6
Human angiotensin converting enzyme n-domain in complex with a phosphinic tripeptide fi
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho
Chains: A, B (608 residues) CATH domain: Unassigned
4ca7
Drosophila angiotensin converting enzyme (ance) in complex with a phosphinic tripeptide fi
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (596 residues) CATH domain: Unassigned
4ca8
Drosophila angiotensin converting enzyme (ance) in complex with a phosphinic tripeptide fii
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: pichia pastoris. Expression_system_taxid: 4922
Chain: A (598 residues) CATH domain: Unassigned