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PDBsum entry 3unf
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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3unf

 

 

 

 

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Contents
Protein chains
230 a.a.
248 a.a.
238 a.a.
233 a.a.
238 a.a.
244 a.a.
243 a.a.
219 a.a.
204 a.a.
196 a.a.
201 a.a.
213 a.a.
216 a.a.
199 a.a.
Ligands
04C ×6
Metals
_CL ×41
__K ×13
IOD ×6
Waters ×985
PDB id:
3unf
Name: Hydrolase/hydrolase inhibitor
Title: Mouse 20s immunoproteasome in complex with pr-957
Structure: Proteasome subunit alpha type-2. Chain: a, o. Proteasome subunit alpha type-4. Chain: b, p. Proteasome subunit alpha type-7. Chain: c, q. Proteasome subunit alpha type-5. Chain: d, r. Proteasome subunit alpha type-1.
Source: Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090
Resolution:
2.90Å     R-factor:   0.237     R-free:   0.275
Authors: E.Huber,M.Basler,R.Schwab,W.Heinemeyer,C.Kirk,M.Groettrup,M.Groll
Key ref: E.M.Huber et al. (2012). Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell, 148, 727-738. PubMed id: 22341445
Date:
15-Nov-11     Release date:   29-Feb-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P49722  (PSA2_MOUSE) -  Proteasome subunit alpha type-2 from Mus musculus
Seq:
Struc: 		234 a.a.
230 a.a.*
Protein chains
Pfam   ArchSchema ?
Q9R1P0  (PSA4_MOUSE) -  Proteasome subunit alpha type-4 from Mus musculus
Seq:
Struc: 		261 a.a.
248 a.a.
Protein chains
Pfam   ArchSchema ?
Q9Z2U0  (PSA7_MOUSE) -  Proteasome subunit alpha type-7 from Mus musculus
Seq:
Struc: 		248 a.a.
238 a.a.
Protein chains
Pfam   ArchSchema ?
Q9Z2U1  (PSA5_MOUSE) -  Proteasome subunit alpha type-5 from Mus musculus
Seq:
Struc: 		241 a.a.
233 a.a.
Protein chains
Pfam   ArchSchema ?
Q9R1P4  (PSA1_MOUSE) -  Proteasome subunit alpha type-1 from Mus musculus
Seq:
Struc: 		263 a.a.
238 a.a.
Protein chains
Pfam   ArchSchema ?
O70435  (PSA3_MOUSE) -  Proteasome subunit alpha type-3 from Mus musculus
Seq:
Struc: 		255 a.a.
244 a.a.
Protein chains
Pfam   ArchSchema ?
Q9QUM9  (PSA6_MOUSE) -  Proteasome subunit alpha type-6 from Mus musculus
Seq:
Struc: 		246 a.a.
243 a.a.
Protein chains
Pfam   ArchSchema ?
O35955  (PSB10_MOUSE) -  Proteasome subunit beta type-10 from Mus musculus
Seq:
Struc: 		273 a.a.
219 a.a.
Protein chains
Pfam   ArchSchema ?
Q9R1P1  (PSB3_MOUSE) -  Proteasome subunit beta type-3 from Mus musculus
Seq:
Struc: 		205 a.a.
204 a.a.
Protein chains
Pfam   ArchSchema ?
Q9R1P3  (PSB2_MOUSE) -  Proteasome subunit beta type-2 from Mus musculus
Seq:
Struc: 		201 a.a.
196 a.a.
Protein chains
Pfam   ArchSchema ?
P28063  (PSB8_MOUSE) -  Proteasome subunit beta type-8 from Mus musculus
Seq:
Struc: 		276 a.a.
201 a.a.
Protein chains
Pfam   ArchSchema ?
O09061  (PSB1_MOUSE) -  Proteasome subunit beta type-1 from Mus musculus
Seq:
Struc: 		240 a.a.
213 a.a.
Protein chains
Pfam   ArchSchema ?
P99026  (PSB4_MOUSE) -  Proteasome subunit beta type-4 from Mus musculus
Seq:
Struc: 		264 a.a.
216 a.a.
Protein chains
Pfam   ArchSchema ?
P28076  (PSB9_MOUSE) -  Proteasome subunit beta type-9 from Mus musculus
Seq:
Struc: 		219 a.a.
199 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: Chains H, K, N, V, Y, b: E.C.3.4.25.1  - proteasome endopeptidase complex.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Cleavage at peptide bonds with very broad specificity.

 

 
Cell 148:727-738 (2012)
PubMed id: 22341445  
 
 
Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.
E.M.Huber, M.Basler, R.Schwab, W.Heinemeyer, C.J.Kirk, M.Groettrup, M.Groll.
 
  ABSTRACT  
 
No abstract given.

 

 

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