_EC 3.4.25.1 Proteasome endopeptidase complex. 109 PDB entries  
EC 3.-.-.- Hydrolases. [20,909 PDB entries]
EC 3.4.-.- Acting on peptide bonds (peptide hydrolases). [6,824 PDB entries]
EC 3.4.25.- Threonine endopeptidases. [127 PDB entries]
EC 3.4.25.1 Proteasome endopeptidase complex. [109 PDB entries]    
1fnt

Reaction: Cleavage of peptide bonds with very broad specificity.
Other name(s): Ingensin. Lens neutral proteinase. Macropain. Multicatalytic endopeptidase complex. Multicatalytic proteinase (complex). Prosome. Proteasome.
Comments: A 20-S protein composed of 28 subunits arranged in four rings of seven. The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity. In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities. The molecule is barrel-shaped, and the active sites are on the inner surfaces.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 109 PDB entries in enzyme class E.C.3.4.25.1

  PDB code Protein
1fnt
Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator pa26 from trypanosome brucei at 3.2 angstroms resolution
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (238 residues) CATH domain: 3.60.20.10
1g0u
A gated channel into the proteasome core particle
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Variant: sub61. Variant: sub61
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (246 residues) CATH domain: 3.60.20.10
1g65
Crystal structure of epoxomicin:20s proteasome reveals a mol basis for selectivity of alpha,beta-epoxyketone proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: sc288. Cellular_location: cytoplasm. Saccharomyces cerevisiae s288c. Synthetic: yes. Other_details: the natural product epoxomicin was isolated actinomycetes strain
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
1iru
Crystal structure of the mammalian 20s proteasome at 2.75 a resolution
Source: Bos taurus. Cattle. Organism_taxid: 9913. Tissue: liver. Tissue: liver
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (244 residues) CATH domain: 3.60.20.10
1j2p
Alpha-ring from the proteasome from archaeoglobus fulgidus
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G (243 residues) CATH domain: 3.60.20.10
1j2q
20s proteasome in complex with calpain-inhibitor i from arch fulgidus
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (237 residues) CATH domain: 3.60.20.10
1jd2
Crystal structure of the yeast 20s proteasome:tmc-95a comple covalent proteasome inhibitor
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Variant: sub61. Apiospora montagnei. Organism_taxid: 255776
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
1pma
Proteasome from thermoplasma acidophilum
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (221 residues) CATH domain: 3.60.20.10
1q5q
The rhodococcus 20s proteasome
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: bl21. Gene: prca(1). Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: prcb(1).
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (219 residues) CATH domain: 3.60.20.10
1q5r
The rhodococcus 20s proteasome with unprocessed pro-peptides
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Strain: bl21. Gene: prca(1). Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: prcb(1).
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (219 residues) CATH domain: 3.60.20.10
1ryp
Crystal structure of the 20s proteasome from yeast at 2.4 angstroms resolution
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (243 residues) CATH domain: 3.60.20.10
1vsy
Proteasome activator complex
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (243 residues) CATH domain: 3.60.20.10
1ya7
Implications for interactions of proteasome with pan and pa7 the 1.9 a structure of a proteasome-11s activator complex
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: psmb. Trypanosoma brucei. Organism_taxid: 5691.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (227 residues) CATH domain: 3.60.20.10
1yar
Structure of archeabacterial 20s proteasome mutant d9s- pa26
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: psmb. Trypanosoma brucei. Organism_taxid: 5691.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (221 residues) CATH domain: 3.60.20.10
1yau
Structure of archeabacterial 20s proteasome- pa26 complex
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Trypanosoma brucei. Organism_taxid: 5691.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (222 residues) CATH domain: 3.60.20.10
1z7q
Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator pa26 from trypanosome brucei at 3.2 angstroms resolution
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Trypanosoma brucei. Organism_taxid: 5691. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (243 residues) CATH domain: 3.60.20.10
2f16
Crystal structure of the yeast 20s proteasome in complex wit bortezomib
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
2fak
Crystal structure of salinosporamide a in complex with the yeast 20s proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
2fhg
Crystal structure of mycobacterial tuberculosis proteasome
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: prca. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: prcb.
Chains: A, H, B, C, D, E, F, G, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (220 residues) CATH domain: 3.60.20.10
2fhh
Crystal structure of mycobacterium tuberculosis proteasome i with a peptidyl boronate inhibitor mln-273
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: prca. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: prcb.
Chains: A, H, B, C, D, E, F, G, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (220 residues) CATH domain: 3.60.20.10
2fny
Homobelactosin c bound to the yeast 20s proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Baker's yeast
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
2gpl
Tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: prs4, pre8. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Gene: prs5, pre9. Gene: pre6. Gene: pup2, doa5.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
2h6j
Crystal structure of the beta f145a rhodococcus proteasome ( target)
Source: Rhodococcus erythropolis. Organism_taxid: 1833. Gene: prca 1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: prcb 1.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (219 residues) CATH domain: 3.60.20.10
2jay
Proteasome beta subunit prcb from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (193 residues) CATH domain: 3.60.20.10
2ku1
Dynamic regulation of archaeal proteasome gate opening as studied by trosy-nmr
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma, ta1288. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: codon+ (ripl).
Chains: A, B, C, D, E, F, G (237 residues) CATH domain: 3.60.20.10
2ku2
Dynamic regulation of archaeal proteasome gate opening as studied by trosy-nmr
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma, ta1288. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: codon+ (ripl).
Chains: A, B, C, D, E, F, G (237 residues) CATH domain: 3.60.20.10
2z5c
Crystal structure of a novel chaperone complex for yeast 20s proteasome assembly
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: C, F (189 residues) CATH domain: 3.60.20.10
2zcy
Yeast 20s proteasome:syringolin a-complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: w303. Strain: w303
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 0, 1 (250 residues) CATH domains: 3.60.20.10 3.60.20.10
3bdm
Yeast 20s proteasome:glidobactin a-complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Strain: w303. Strain: w303
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 0, 1 (250 residues) CATH domains: 3.60.20.10 3.60.20.10
3c91
Thermoplasma acidophilum 20s proteasome with an open gate
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (227 residues)
3c92
Thermoplasma acidophilum 20s proteasome with a closed gate
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (224 residues)
3d29
Proteasome inhibition by fellutamide b
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Strain: bakers yeast. Other_details: native purification from cell lysate. Other_details: native purification from cell lysate
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3dy3
Crystal structure of yeast 20s proteasome in complex with the epimer form of spirolactacystin
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Cell_line: native purification. Other_details: 20s proteasome was prepared from yeast under native conditions. Native conditions
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3dy4
Crystal structure of yeast 20s proteasome in complex with spirolactacystin
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Cell_line: native purification. Other_details: 20s proteasome was prepared from yeast under conditions. Conditions
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3e47
Crystal structure of the yeast 20s proteasome in complex with homobelactosin c
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Other_details: cells are commercially available. Other_details: cells are commercially available
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3gpj
Crystal structure of the yeast 20s proteasome in complex with syringolin b
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3gpt
Crystal structure of the yeast 20s proteasome in complex with salinosporamide derivatives: slow substrate ligand
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3gpw
Crystal structure of the yeast 20s proteasome in complex with salinosporamide derivatives: irreversible inhibitor ligand
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3h4p
Proteasome 20s core particle from methanocaldococcus jannaschii
Source: Methanocaldococcus jannaschii. Methanococcus jannaschii. Organism_taxid: 2190. Gene: psma, mj0591. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: psmb, mj1237. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, a, b, c, d, e, f, g, H, I, J, K, L, M, N, h, i, j, k, l, m, n (232 residues)
3h6f
Crystal structure of mycobacterium tuberculosis proteasome modified by inhibitor ht1171
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2170, prcb, rv2110c.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (215 residues) CATH domain: 3.60.20.10
3h6i
Crystal structure of mycobacterium tuberculosis proteasome modified by inhibitor gl1
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2170, prcb, rv2110c.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (216 residues) CATH domain: 3.60.20.10
3hf9
Crystal structure of mycobacterium tuberculosis proteasome open-gate mutant modified by inhibitor gl1
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2170, prcb, rv2110c.
Chains: A, B, D, F, I, K, M, O, Q, S, U, W, Y, 1, a, b, d, f, i, k, m, o, q, s, u, w, y, 3 (211 residues) CATH domain: 3.60.20.10
3hfa
Crystal structure of mycobacterium tuberculosis proteasome open-gate mutant
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mt2170, prcb, rv2110c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: prca, rv2109c.
Chains: D, A, B, F, I, K, M, O, Q, S, U, W, Y, 1 (213 residues) CATH domain: 3.60.20.10
3hye
Crystal structure of 20s proteasome in complex with hydroxylated salinosporamide
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3ipm
Crystal structure of archaeal 20s proteasome in complex with terminus of pan
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma, ta1288. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: psmb, ta0612. Trypanosoma brucei, methanocaldococcus jannaschii. Organism_taxid: 5691, 2190.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (227 residues) CATH domain: 3.60.20.10
3jrm
Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma, ta1288. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: psmb, ta0612. Trypanosoma brucei. Organism_taxid: 5691. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (227 residues) CATH domain: 3.60.20.10
3jse
Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: psmb, ta0612. Trypanosoma brucei. Organism_taxid: 5691. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (227 residues) CATH domain: 3.60.20.10
3jtl
Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator
Source: Thermoplasma acidophilum. Organism_taxid: 2303. Gene: psma, ta1288. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: psmb, ta0612. Trypanosoma brucei. Organism_taxid: 5691. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (227 residues) CATH domain: 3.60.20.10
3krd
Crystal structure of mycobacterium tuberculosis proteasome i with fellutamide b
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h37rv. Gene: mt2169, prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2170, prcb, rv2110c.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (214 residues) CATH domain: 3.60.20.10
3l5q
Proteasome activator complex
Source: Saccharomyces cerevisiae. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, G, H, I, J, K, L, B, M, N, O, P, Q, R, C, S, T, U, V, W, X, D, Y, Z, 1, 2, 3, 4 (243 residues) CATH domain: 3.60.20.10
3mfe
Crystal structure of mycobacterium tuberculosis proteasome o mutant with h0 movement
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mt2170, prcb, rv2110c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2169, prca, rv2109c.
Chains: H, C, E, G, J, L, N, P, R, T, V, X, Z, 2, D, A, B, F, I, K, M, O, Q, S, U, W, Y, 1 (222 residues) CATH domain: 3.60.20.10
3mg0
Structure of yeast 20s proteasome with bortezomib
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3mg4
Structure of yeast 20s proteasome with compound 1
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3mg6
Structure of yeast 20s open-gate proteasome with compound 6
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3mg7
Structure of yeast 20s open-gate proteasome with compound 8
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3mg8
Structure of yeast 20s open-gate proteasome with compound 16
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3mi0
Crystal structure of mycobacterium tuberculosis proteasome a
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: rv2109c. Gene: mt2169, prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mt2170, prcb, rv2110c.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (215 residues) CATH domain: 3.60.20.10
3mka
Crystal structure of mycobacterium tuberculosis proteasome w propetide and an t1a mutation at beta-subunit
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: mt2169, prca, rv2109c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: mt2170, prcb, rv2110c.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (222 residues) CATH domain: 3.60.20.10
3nzj
Crystal structure of yeast 20s proteasome in complex with li
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3nzw
Crystal structure of the yeast 20s proteasome in complex wit
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3nzx
Crystal structure of the yeast 20s proteasome in complex wit 2c
Source: Saccharomyces cerevisiae. Brewer's yeast,lager beer yeast,yeast. Organism_taxid: 4932. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3oeu
Structure of yeast 20s open-gate proteasome with compound 24
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3oev
Structure of yeast 20s open-gate proteasome with compound 25
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3okj
Alpha-keto-aldehyde binding mechanism reveals a novel lead s motif for proteasome inhibition
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3sdi
Structure of yeast 20s open-gate proteasome with compound 20
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (246 residues) CATH domain: 3.60.20.10
3sdk
Structure of yeast 20s open-gate proteasome with compound 34
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3shj
Proteasome in complex with hydroxyurea derivative hu10
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3tdd
Crystal structure of yeast cp in complex with belactosin c
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (250 residues) CATH domain: 3.60.20.10
3un4
Yeast 20s proteasome in complex with pr-957 (morpholine)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
3un8
Yeast 20s proteasome in complex with pr-957 (epoxide)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
3unb
Mouse constitutive 20s proteasome in complex with pr-957
Source: Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z, 1, 2, 3, 4 (231 residues) CATH domain: 3.60.20.10
3une
Mouse constitutive 20s proteasome
Source: Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b, c, d, e, f, g, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z, 1, 2, 3, 4 (233 residues) CATH domain: 3.60.20.10
3unf
Mouse 20s immunoproteasome in complex with pr-957
Source: Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (230 residues) CATH domain: 3.60.20.10
3unh
Mouse 20s immunoproteasome
Source: Mus musculus. Mouse. Organism_taxid: 10090. Organism_taxid: 10090
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (230 residues) CATH domain: 3.60.20.10
4b4t
Near-atomic resolution structural model of the yeast 26s pro
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4bgr
Structure of the 26s proteasome with atp-ys bound provides i into the mechanism of nucleotide-dependent substrate transl
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4c0v
Structure of the 26s proteasome with atp-ys bound provides insights into the mechanism of nucleotide-dependent substrate translocation
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4cr2
Deep classification of a large cryo-em dataset defines the conformational landscape of the 26s proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4cr3
Deep classification of a large cryo-em dataset defines the conformational landscape of the 26s proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4cr4
Deep classification of a large cryo-em dataset defines the conformational landscape of the 26s proteasome
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: 1, 2, 3, 4, 5, 6, 7, A, B, C, D, E, F, G (205 residues)
4eu2
Crystal structure of 20s proteasome with novel inhibitor k-7
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: s288c. Strain: s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, 1, 2 (241 residues) CATH domain: 3.60.20.10
4fzc
20s yeast proteasome in complex with cepafungin i
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4fzg
20s yeast proteasome in complex with glidobactin
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4g4s
Structure of proteasome-pba1-pba2 complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: scl1, prc2, prs2, ygl011c. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Gene: pre8, prs4, yml092c. Gene: pre9, prs5, ygr135w.
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N (241 residues) CATH domain: 3.60.20.10
4gk7
Yeast 20s proteasome in complex with the syringolin-glidobac chimera
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Synthetic: yes. Synthetic construct. Synthetic. Organism_taxid: 32630
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4hnp
Crystal structure of yeast 20s proteasome in complex with vi carmaphycin analogue vnk1
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Saccharomyces cerevisiae. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4hrc
Crystal structure of yeast 20s proteasome in complex with ep carmaphycin analogue 3
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (249 residues) CATH domain: 3.60.20.10
4hrd
Crystal structure of yeast 20s proteasome in complex with th product carmaphycin a
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Saccharomyces cerevisiae s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4inr
Yeast 20s proteasome in complex with the vinyl sulfone lu102
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4int
Yeast 20s proteasome in complex with the vinyl sulfone lu122
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4inu
Yeast 20s proteasome in complex with the vinyl sulfone lu112
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4j70
Yeast 20s proteasome in complex with the belactosin derivati
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4jsq
Yeast 20s proteasome in complex with the dimerized linear mi tmc-95a - ycp:4e
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4jsu
Yeast 20s proteasome in complex with the dimerized linear mi tmc-95a - ycp:3a
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4jt0
Yeast 20s proteasome in complex with the dimerized linear mi tmc-95a - ycp:4a
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Synthetic: yes. Synthetic: yes
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4lqi
Yeast 20s proteasome in complex with vibralactone
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Organism_taxid: 4932
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4nnn
Ycp in complex with mg132
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4nnw
Ycp in complex with z-leu-leu-leu-ketoaldehyde
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4no1
Ycp in complex with z-leu-leu-leu-b(oh)2
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4no6
Ycp in complex with z-leu-leu-leu-vinylsulfone
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4no8
Ycp in complex with z-leu-leu-leu-ketoamide
Source: Saccharomyces cerevisiae s288c. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4no9
Ycp in complex with z-leu-leu-leu-epoxyketone
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues) CATH domain: 3.60.20.10
4q1s
Yeast 20s proteasome in complex with kendomycin
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4qlq
Ycp in complex with tripeptidic epoxyketone inhibitor 8
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4qls
Ycp in complex with tripeptidic epoxyketone inhibitor 11
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4qlt
Ycp in complex with tripeptidic epoxyketone inhibitor 2 (pr9
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4qlu
Ycp in complex with tripeptidic epoxyketone inhibitor 9
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4qlv
Ycp in complex with tripeptidic epoxyketone inhibitor 17
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)
4r02
Ycp in complex with bsc4999 (alpha-keto phenylamide)
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: pre2, doa3, prg1, ypr103w, p8283.10. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Strain: atcc 204508 / s288c
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b (250 residues)