PDBsum entry 3uix

Transferase/inhibitor

PDB id: 3uix

Contents

Protein chain

266 a.a.

Ligands

Q17

SO4

GOL

Metals

_CL ×2

_CA

Waters ×241

PDB id:

3uix

Name:

Transferase/inhibitor

Title:

Crystal structure of pim1 kinase in complex with small molecule inhibitor

Structure:

Proto-oncogene serine/threonine-protein kinase pim-1. Chain: a. Fragment: protein kinase domain (unp residues 120-404). Engineered: yes

Source:

Homo sapiens. Organism_taxid: 9606. Gene: pim1. Expressed in: cell-free protein synthesis.

Resolution:

2.20Å R-factor: 0.168 R-free: 0.201

Authors:

L.J.Parker

Key ref:

K.Tsuganezawa et al. (2012). A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide. J Mol Biol, 417, 240-252. PubMed id: 22306408

Date:

06-Nov-11 Release date: 11-Apr-12

Protein chain

P11309  (PIM1_HUMAN) -  Serine/threonine-protein kinase pim-1 from Homo sapiens

Seq: 313 a.a.

Struc: 266 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Mol Biol 417:240-252 (2012)

PubMed id: 22306408

A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide.

K.Tsuganezawa, H.Watanabe, L.Parker, H.Yuki, S.Taruya, Y.Nakagawa, D.Kamei, M.Mori, N.Ogawa, Y.Tomabechi, N.Handa, T.Honma, S.Yokoyama, H.Kojima, T.Okabe, T.Nagano, A.Tanaka.

ABSTRACT

No abstract given.