_EC 2.7.11.1 Non-specific serine/threonine protein kinase. 1,493 PDB entries  
EC 2.-.-.- Transferases. [17,949 PDB entries]
EC 2.7.-.- Transferring phosphorous-containing groups. [10,916 PDB entries]
EC 2.7.11.- Protein-serine/threonine kinases. [2,980 PDB entries]
EC 2.7.11.1 Non-specific serine/threonine protein kinase. [1,493 PDB entries]    
1aue

Reaction: Atp + a protein = adp + a phosphoprotein.
 


ATP
+
protein
=
ADP
+ phosphoprotein
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Protein phosphokinase. Protein serine kinase. Protein serine-threonine kinase. Protein-serine kinase. Serine kinase. Serine protein kinase. Serine(threonine) protein kinase. Serine-specific protein kinase. Serine/threonine protein kinase. Threonine-specific protein kinase.
Comments: This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. Formerly Ec 2.7.1.37 and Ec 2.7.1.70.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 1493 PDB entries in enzyme class E.C.2.7.11.1

  PDB code Protein
1aue
Fkbp-rapamycin binding domain (frb) of the fkbp-rapamycin associated protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: jurkat tcell cdna library. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (92 residues) CATH domain: 1.20.120.150
1bpv
Titin module a71 from human cardiac muscle, nmr, 50 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Tissue: muscle. Organelle: sarcomere. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (104 residues) CATH domain: 2.60.40.10
1c1y
Crystal structure of rap.Gmppnp in complex with the ras- binding-domain of c-raf1 kinase (rafrbd).
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: B (77 residues) CATH domain: 3.10.20.90
Bound ligand:   Het Group GTP is 96.00% similar to enzyme reactant ATP
1cf4
Cdc42/ack gtpase-binding domain complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Organism_taxid: 9606
Chain: B (44 residues) CATH domain: 4.10.680.10
1cja
Actin-fragmin kinase, catalytic domain from physarum polycephalum
Source: Physarum polycephalum. Organism_taxid: 5791. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (327 residues) CATH domains: 3.30.1010.10 1.10.1070.11
Bound ligand:   Het Group AMP is 85.00% similar to enzyme product ADP
1cki
Recombinant casein kinase i delta truncation mutant containing residues 1-317
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: 293. Organ: testes. Gene: t7. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: t7 RNA polymerase
Chains: A, B (292 residues) CATH domains: 3.30.200.20 1.10.510.10
1ckj
Casein kinase i delta truncation mutant containing residues 1-317 complex with bound tungstate
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: 293. Organ: testes. Gene: t7. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: host bl21(de3)
Chains: A, B (296 residues) CATH domains: 3.30.200.20 1.10.510.10
1csn
Binary complex of casein kinase-1 with mgatp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1d2z
Three-dimensional structure of a complex between the death domains of pelle and tube
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C (102 residues) CATH domain: 1.10.533.10
Bound ligand:   Het Group EPE is 40.00% similar to enzyme reactant protein
1daw
Crystal structure of a binary complex of protein kinase ck2 (alpha-subunit) and mg-amppnp
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1day
Crystal structure of a binary complex of protein kinase ck2 (alpha-subunit) and mg-gmppnp
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group GNP is 78.00% similar to enzyme product ADP
1ds5
Dimeric crystal structure of the alpha subunit in complex with two beta peptides mimicking the architecture of the tetrameric protein kinase ck2 holoenzyme.
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide corresponding to the sequence 181-203 of the beta-subunit of human protein kinase ck2.
Chains: A, B, C, D (328 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AMP is 85.00% similar to enzyme product ADP
1e0a
Cdc42 complexed with the gtpase binding domain of p21 activated kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Cellular_location: cytoplasm. Expressed in: escherichia coli. Expression_system_taxid: 469008. Rattus norvegicus. Norway rat. Organism_taxid: 10116.
Chain: B (46 residues) CATH domain: 3.90.810.10
Bound ligand:   Het Group GNP is 78.79% similar to enzyme product ADP
1e7u
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Sus scrofa. Wild boar. Organism_taxid: 9823. Cell: neutrophil. Plasmid: pachlt-c. Gene: p120s144c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (872 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e7v
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Sus scrofa. Wild boar. Organism_taxid: 9823. Cell: neutrophil. Gene: p120s144c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (850 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e8w
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Sus scrofa. Wild boar. Organism_taxid: 9823. Strain: sf9. Cell: neutrophil. Plasmid: pachlt-c. Gene: p120s144c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (851 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e8x
Structural insights into phoshoinositide 3-kinase enzymatic mechanism and signalling
Source: Sus scrofa. Wild boar. Organism_taxid: 9823. Strain: sf9. Cell: neutrophil. Plasmid: pachlt-c. Gene: p120s144c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (841 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e8y
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (841 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e8z
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (839 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1e90
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, ly294002, quercetin, myricetin and staurosporine
Source: Sus scrofa. Wild boar. Organism_taxid: 9823. Strain: sf9. Cell: neutrophil. Plasmid: pachlt-c. Gene: p120s144c. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (844 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1ees
Solution structure of cdc42hs complexed with a peptide derived from p-21 activated kinase, nmr, 20 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: placenta. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. House mouse. Organism_taxid: 10090.
Chain: B (46 residues) CATH domain: 3.90.810.10
1eh4
Binary complex of casein kinase-1 from s. Pombe with an atp competitive inhibitor, ic261
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: schizosaccharomyces pombe
Chains: A, B (293 residues) CATH domains: 3.30.200.20 1.10.510.10
1eqf
Crystal structure of the double bromodomain module from human tafii250
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 1.20.920.10 1.20.920.10
1f0q
Crystal structure of the alpha subunit of protein kinase ck2 in complex with the nucleotide competitive inhibitor emodin
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10
1f3m
Crystal structure of human serine/threonine kinase pak1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, C, B, D (70 residues) CATH domain: 3.90.810.10
1fap
The structure of the immunophilin-immunosuppressant fkbp12- rapamycin complex interacting with human frap
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library. Expressed in: escherichia coli. Expression_system_taxid: 562. (Clontech, palo alto, ca).
Chain: B (95 residues) CATH domain: 1.20.120.150
1faq
Raf-1 cysteine rich domain, nmr, 27 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (52 residues) CATH domain: 3.30.60.20
1far
Raf-1 cysteine rich domain, nmr, minimized average structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (52 residues) CATH domain: 3.30.60.20
1g1c
I1 domain from titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (98 residues) CATH domain: 2.60.40.10
1gng
Glycogen synthase kinase-3 beta (gsk3) complex with frattide peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
Chains: A, B (350 residues) CATH domains: 3.30.200.20 1.10.510.10
1gua
Human rap1a, residues 1-167, double mutant (e30d,k31e) complexed with gppnhp and the ras-binding-domain of human c-raf1, residues 51-131
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human c-raf1 gene residues 51. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: purified as a gst-fusion protein with
Chain: B (76 residues) CATH domain: 3.10.20.90
Bound ligand:   Het Group GNP is 78.00% similar to enzyme product ADP
1gxc
Fha domain from human chk2 kinase in complex with a synthetic phosphopeptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, D, G, J (116 residues) CATH domain: 2.60.200.20
1gzk
Molecular mechanism for the regulation of protein kinase b/ akt by hydrophobic motif phosphorylation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (271 residues) CATH domains: 1.10.510.10 3.30.200.20
1gzn
Structure of pkb kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: insect cells.
Chain: A (272 residues) CATH domains: 1.10.510.10 3.30.200.20
1gzo
Structure of protein kinase b unphosphorylated
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 1.10.510.10 3.30.200.20
1h10
High resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to ins(1,3,4,5)-tetrakisphophate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (118 residues) CATH domain: 2.30.29.30
1h1w
High resolution crystal structure of the human pdk1 catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (285 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1h4l
Structure and regulation of the cdk5-p25(nck5a) complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Organism_taxid: 9606
Chains: A, B (278 residues) CATH domains: 3.30.200.20 1.10.510.10
1h8f
Glycogen synthase kinase 3 beta.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: baculovirus. Expression_system_taxid: 10469.
Chains: A, B (352 residues) CATH domains: 3.30.200.20 1.10.510.10
1he8
Ras g12v - pi 3-kinase gamma complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: c41(de3).
Chain: A (749 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
1how
The x-ray crystal structure of sky1p, an sr protein kinase in yeast
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ymr216c. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (346 residues) CATH domains: 3.30.200.20 1.10.510.10
1i09
Structure of glycogen synthase kinase-3 (gsk3b)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B (338 residues) CATH domains: 3.30.200.20 1.10.510.10
1ia8
The 1.7 a crystal structure of human cell cycle checkpoint kinase chk1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
1ia9
Crystal structure of the atypical protein kinase domain of a trp ca-channel, chak (amppnp complex)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: chak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (276 residues) CATH domains: 3.30.200.20 3.20.200.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1iah
Crystal structure of the atypical protein kinase domain of a trp ca-channel, chak (adp-mg complex)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: chak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (276 residues) CATH domains: 3.30.200.20 3.20.200.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1iaj
Crystal structure of the atypical protein kinase domain of a trp ca-channel, chak (apo)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: chak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (253 residues) CATH domains: 3.30.200.20 3.20.200.10
1ig1
1.8a x-ray structure of ternary complex of a catalytic domain of death-associated protein kinase with atp analogue and mn.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1ik7
Crystal structure of the uncomplexed pelle death domain
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: pelle. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (52 residues) CATH domain: 1.20.5.530
1j1b
Binary complex structure of human tau protein kinase i with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (354 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1j1c
Binary complex structure of human tau protein kinase i with adp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (354 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1j91
Crystal structure of z. Mays ck2 kinase alpha subunit in complex with the atp-competitive inhibitor 4,5,6,7- tetrabromobenzotriazole
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1jam
Crystal structure of apo-form of z. Mays ck2 protein kinase alpha subunit
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1jkk
2.4a x-ray structure of ternary complex of a catalytic domain of death-associated protein kinase with atp analogue and mg.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1jkl
1.6a x-ray structure of binary complex of a catalytic domain of death-associated protein kinase with atp analogue
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1jks
1.5a x-ray structure of apo form of a catalytic domain of death-associated protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
1jkt
Tetragonal crystal form of a catalytic domain of death-assoc protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (276 residues) CATH domains: 3.30.200.20 1.10.510.10
1jwh
Crystal structure of human protein kinase ck2 holoenzyme
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B (336 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1k1f
Structure of the bcr-abl oncoprotein oligomerization domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D, E, F, G, H (67 residues) CATH domain: 4.10.280.30
1kgd
Crystal structure of the guanylate kinase-like domain of human cask
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (175 residues) CATH domains: 3.40.50.300 3.30.63.10
1koa
Twitchin kinase fragment (c.Elegans), autoregulated protein kinase and immunoglobulin domains
Source: Caenorhabditis elegans. Organism_taxid: 6239. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (447 residues) CATH domains: 3.30.200.20 1.10.510.10 2.60.40.10
1kwa
Human cask/lin-2 pdz domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: liver. Cellular_location: membrane-associated. Gene: hcask. Expressed in: escherichia coli. Expression_system_taxid: 562. Resistant.
Chains: A, B (88 residues) CATH domain: 2.30.42.10
1kwp
Crystal structure of mapkap2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (319 residues) CATH domains: 3.30.200.20 1.10.510.10
1l0o
Crystal structure of the bacillus stearothermophilus anti- sigma factor spoiiab with the sporulation sigma factor sigmaf
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: spoiiab. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (141 residues) CATH domain: 3.30.565.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1ll8
Structure and interactions of pas kinase n-terminal pas domain: model for intramolecular kinase regulation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (114 residues) CATH domain: 3.30.450.20
1lp4
Crystal structure of a binary complex of the catalytic subunit of protein kinase ck2 with mg-amppnp
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1lpu
Low temperature crystal structure of the apo-form of the catalytic subunit of protein kinase ck2 from zea mays
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1lr4
Room temperature crystal structure of the apo-form of the catalytic subunit of protein kinase ck2 from zea mays
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1m2p
Crystal structure of 1,8-di-hydroxy-4-nitro- anthraquinone/ck2 kinase complex
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (325 residues) CATH domains: 3.30.200.20 1.10.510.10
1m2q
Crystal structure of 1,8-di-hydroxy-4-nitro-xanten-9- one/ck2 kinase complex
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1m2r
Crystal structure of 5,8-di-amino-1,4-di-hydroxy- anthraquinone/ck2 kinase complex
Source: Zea mays. Organism_taxid: 4577. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10
1mfw
Structure of n-terminal doublecortin domain from dclk: selenomethionine labeled protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (106 residues) CATH domain: 3.10.20.230
1mg4
Structure of n-terminal doublecortin domain from dclk: wild type protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (101 residues) CATH domain: 3.10.20.230
1mq4
Crystal structure of aurora-a protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.
Chain: A (261 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1mru
Intracellular ser/thr protein kinase domain of mycobacterium tuberculosis pknb.
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21 (de3).
Chains: A, B (269 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AGS is 93.00% similar to enzyme reactant ATP
1mrv
Crystal structure of an inactive akt2 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: akt2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (261 residues) CATH domains: 1.10.510.10 3.30.200.20
1mry
Crystal structure of an inactive akt2 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: akt2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (270 residues) CATH domains: 1.10.510.10 3.30.200.20
1muo
Crystal structure of aurora-2, an oncogenic serine- threonine kinase
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (251 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ADN is 70.00% similar to enzyme product ADP
1na7
Crystal structure of the catalytic subunit of human protein kinase ck2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10
1nct
Titin module m5, n-terminally extended, nmr
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Tissue: cardiac muscle. Organelle: cytoplasma/sarcomere. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (98 residues) CATH domain: 2.60.40.10
1ncu
Titin module m5, n-terminally extended, nmr
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Tissue: cardiac muscle. Organelle: cytoplasma/sarcomere. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (98 residues) CATH domain: 2.60.40.10
1nsg
The structure of the immunophilin-immunosuppressant fkbp12-r complex interacting with human frap
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library. Expressed in: escherichia coli. Expression_system_taxid: 562. Palo alto, ca). Palo alto, ca)
Chain: B (94 residues) CATH domain: 1.20.120.150
1nty
Crystal structure of the first dh/ph domain of trio to 1.7 a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: trio. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (305 residues) CATH domains: 1.20.900.10 2.30.29.30
1nvq
The complex structure of checkpoint kinase chk1/ucn-01
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Synthetic: yes
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1nvr
The complex structure of checkpoint kinase chk1/staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Synthetic: yes
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1nvs
The complex structure of checkpoint kinase chk1/sb218078
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Synthetic: yes
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1nxk
Crystal structure of staurosporine bound to map kap kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (290 residues) CATH domains: 3.30.200.20 1.10.510.10
1ny3
Crystal structure of adp bound to map kap kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1o6k
Structure of activated form of pkb kinase domain s474d with gsk3 peptide and amp-pnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (318 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1o6l
Crystal structure of an activated akt/protein kinase b (pkb-pif chimera) ternary complex with amp-pnp and gsk3 peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (317 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1o6y
Catalytic domain of pknb kinase from mycobacterium tuberculosis
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: institut pasteur collection
Chain: A (260 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ACP is 81.25% similar to enzyme product ADP
1o9u
Glycogen synthase kinase 3 beta complexed with axin peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: axin peptide
Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADZ is 40.74% similar to enzyme product ADP
1oky
Structure of human pdk1 kinase domain in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf21. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (283 residues) CATH domains: 1.10.510.10 3.30.200.20
1okz
Structure of human pdk1 kinase domain in complex with ucn-01
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (278 residues) CATH domains: 1.10.510.10 3.30.200.20
1ol5
Structure of aurora-a 122-403, phosphorylated on thr287, thr288 and bound to tpx2 1-43
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (266 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1ol6
Structure of unphosphorylated d274n mutant of aurora-a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (246 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1ol7
Structure of human aurora-a 122-403 phosphorylated on thr287, thr288
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (264 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1om1
Crystal structure of maize ck2 alpha in complex with iqa
Source: Zea mays. Organism_taxid: 4577
Chain: A (325 residues) CATH domains: 3.30.200.20 1.10.510.10
1p4f
Death associated protein kinase catalytic domain with bound inhibitor fragment
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dapk1 or dapk. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
1p6s
Solution structure of the pleckstrin homology domain of human protein kinase b beta (pkb/akt)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: akt2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (111 residues) CATH domain: 2.30.29.30
1phk
Two structures of the catalytic domain of phosphorylase, kinase: an active protein kinase complexed with nucleotide, substrate-analogue and product
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Organ: skeletal. Tissue: skeletal muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1pjk
Crystal structure of a c-terminal deletion mutant of human p kinase ck2 catalytic subunit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1 or ck2a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
1psb
Solution structure of calcium loaded s100b complexed to a peptide from n-terminal regulatory domain of ndr kinase.
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: s100b. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens.
Chains: C, D (26 residues)
1pyx
Gsk-3 beta complexed with amp-pnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chains: A, B (343 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1q3d
Gsk-3 beta complexed with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10
1q3w
Gsk-3 beta complexed with alsterpaullone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chains: A, B (344 residues) CATH domains: 3.30.200.20 1.10.510.10
1q41
Gsk-3 beta complexed with indirubin-3'-monoxime
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chains: A, B (339 residues) CATH domains: 3.30.200.20 1.10.510.10
1q4l
Gsk-3 beta complexed with inhibitor i-5
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5.
Chains: A, B (342 residues) CATH domains: 3.30.200.20 1.10.510.10
1q5k
Crystal structure of glycogen synthase kinase 3 in complexed with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell: high five cells.
Chains: A, B (345 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group TMU is 41.00% similar to enzyme product ADP
1q8y
The structure of the yeast sr protein kinase, sky1p, with bound adp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sky1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (351 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1q8z
The apoenzyme structure of the yeast sr protein kinase, sky1p
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sky1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (354 residues) CATH domains: 3.30.200.20 1.10.510.10
1q97
The structure of the saccharomyces cerevisiae sr protein kinase, sky1p, with bound atp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sky1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (351 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1q99
Crystal structure of the saccharomyces cerevisiae sr protein kinsae, sky1p, complexed with the non-hydrolyzable atp analogue, amp-pnp
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sky1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (354 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1ql6
The catalytic mechanism of phosphorylase kinase probed by mutational studies
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Tissue: skeletal muscle. Plasmid: pmw172. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1qu6
Structure of the double-stranded RNA-binding domain of the protein kinase pkr reveals the molecular basis of its dsrna-mediated activation
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (179 residues) CATH domains: 3.30.160.20 3.30.160.20
1r0e
Glycogen synthase kinase-3 beta in complex with 3-indolyl-4- arylmaleimide inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Chains: A, B (344 residues) CATH domains: 3.30.200.20 1.10.510.10
1rfa
Nmr solution structure of the ras-binding domain of c-raf-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: fetal liver. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (78 residues) CATH domain: 3.10.20.90
1rrb
The ras-binding domain of raf-1 from rat, nmr, 1 structure
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Cell_line: bl21. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (76 residues) CATH domain: 3.10.20.90
1rso
Hetero-tetrameric l27 (lin-2, lin-7) domain complexes as organization platforms of supra-molecular assemblies
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D (56 residues) CATH domain: 1.10.287.650
1rwi
Extracellular domain of mycobacterium tuberculosis pknd
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: pknd, rv0931c, mt0958, mtcy08c9.08. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, A (254 residues) CATH domain: 2.120.10.30
1rwl
Extracellular domain of mycobacterium tuberculosis pknd
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: pknd, rv0931c, mt0958, mtcy08c9.08. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (254 residues) CATH domain: 2.120.10.30
1s1c
Crystal structure of the complex between the human rhoa and rho-binding domain of human rocki
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: arha, arh12, rhoa, rho12. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: X, Y (69 residues) CATH domain: 1.20.5.730
Bound ligand:   Het Group GNP is 78.00% similar to enzyme product ADP
1s6i
Ca2+-regulatory region (cld) from soybean calcium-dependent protein kinase-alpha (cdpk) in the presence of ca2+ and the junction domain (jd)
Source: Glycine max. Soybean. Organism_taxid: 3847. Gene: cdpk sk5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: ca2+-binding region and c-terminal tail, along with his(6) at c-terminus
Chain: A (182 residues) CATH domains: 1.10.238.10 1.10.238.10
1s6j
N-terminal region of the ca2+-saturated calcium regulatory domain (cld) from soybean calcium-dependent protein kinase- alpha (cdpk)
Source: Glycine max. Soybean. Organism_taxid: 3847. Gene: cdpk sk5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Other_details: 13 residues from an n-terminal his-tag, and the n-terminal domain of the ca2+-regulatory region
Chain: A (87 residues) CATH domain: Unassigned
1suy
Nmr structure of the thkaia180c-ciiabd complex (average mini structure)
Source: Thermosynechococcus elongatus. Organism_taxid: 197221. Strain: bp-1. Gene: kaia. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: kaic.
Chains: C, D (34 residues)
1sv1
Nmr structure of the thkaia180c-ciiabd complex (25-structure
Source: Thermosynechococcus elongatus. Organism_taxid: 197221. Strain: bp-1. Gene: kaia. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: kaic.
Chains: C, D (34 residues)
1tba
Solution structure of a tbp-tafii230 complex: protein mimicry of the minor groove surface of the tata box unwound by tbp, nmr, 25 structures
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Expressed in: escherichia coli. Expression_system_taxid: 562. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli bl21.
Chain: A (67 residues) CATH domain: 1.10.1100.10
1tf7
Crystal structure of circadian clock protein kaic
Source: Synechococcus sp.. Organism_taxid: 1131. Gene: pcc7942. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (484 residues) CATH domains: 3.40.50.300 3.40.50.300
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1th8
Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: inhibitory complex with adp, crystal form ii
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: spoiiab. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spoiiaa.
Chain: A (132 residues) CATH domain: 3.30.565.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1thn
Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: inhibitory complex with adp, crystal form i
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: spoiiab. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spoiiaa.
Chains: A, C (136 residues) CATH domain: 3.30.565.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1tid
Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa: poised for phosphorylation complex with atp, crystal form i
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: spoiiab. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spoiiaa.
Chains: A, C (136 residues) CATH domain: 3.30.565.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1til
Crystal structures of the adp and atp bound forms of the bacillus anti-sigma factor spoiiab in complex with the anti-anti-sigma spoiiaa:poised for phosphorylation complex with atp, crystal form ii
Source: Geobacillus stearothermophilus. Organism_taxid: 1422. Gene: spoiiab. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spoiiaa.
Chains: A, C, E (141 residues) CATH domain: 3.30.565.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1tit
Titin, ig repeat 27, nmr, minimized average structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: 293. Organ: heart. Tissue: muscle. Organelle: sarcomere. Gene: titin gene. Expressed in: escherichia coli bl21.
Chain: A (89 residues) CATH domain: 2.60.40.10
1tiu
Titin, ig repeat 27, nmr, 24 structures
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: 293. Organ: heart. Tissue: muscle. Organelle: sarcomere. Gene: titin gene. Expressed in: escherichia coli bl21.
Chain: A (89 residues) CATH domain: 2.60.40.10
1tki
Autoinhibited serine kinase domain of the giant muscle protein titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Organ: heart. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (321 residues) CATH domains: 3.30.200.20 1.10.510.10
1tnm
Tertiary structure of an immunoglobulin-like domain from the muscle protein titin: a new member of the i set
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: cardiac muscle. Gene: ttn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (91 residues) CATH domain: 2.60.40.10
1tnn
Tertiary structure of an immunoglobulin-like domain from the muscle protein titin: a new member of the i set
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Organ: cardiac muscle. Gene: ttn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (91 residues) CATH domain: 2.60.40.10
1tqi
Crystal structure of a. Fulgidus rio2 serine protein kinase
Source: Archaeoglobus fulgidus. Organism_taxid: 224325. Strain: dsm 4304. Gene: rio2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 1.10.10.10 3.30.200.20 1.10.510.10
1tqm
Crystal structure of a. Fulgidus rio2 serine protein kinase amppnp
Source: Archaeoglobus fulgidus. Organism_taxid: 224325. Strain: dsm 4304. Gene: rio2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 1.10.10.10 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
1tqp
Crystal structure of a. Fulgidus rio2 serine protein kinase atp
Source: Archaeoglobus fulgidus. Organism_taxid: 224325. Strain: dsm 4304. Gene: rio2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 1.10.10.10 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1u2h
X-ray structure of the n-terminally truncated human apep-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: arotic preferentially expressed gene 1. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: psf clone id 111408 and rzpd id psfep250b117
Chain: A (96 residues) CATH domain: 2.60.40.10
1u3o
Solution structure of rat kalirin n-terminal sh3 domain
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Organ: brain. Gene: kalirin, hapip, duo. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (67 residues) CATH domain: 2.30.30.40
1u46
Crystal structure of the unphosphorylated kinase domain of the tyrosine kinase ack1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
Chains: A, B (255 residues) CATH domains: 3.30.200.20 1.10.510.10
1u4d
Structure of the ack1 kinase domain bound to debromohymenialdisine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (258 residues) CATH domains: 3.30.200.20 1.10.510.10
1u54
Crystal structures of the phosphorylated and unphosphorylate domains of the cdc42-associated tyrosine kinase ack1 bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ack1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
Chains: A, B (263 residues) CATH domains: 3.30.200.20 1.10.510.10
1u5q
Crystal structure of the tao2 kinase domain: activation and specifity of a ste20p map3k
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: serine/threonine protein kinase tao2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (309 residues) CATH domains: 3.30.200.20 1.10.510.10
1u5r
Crystal structure of the tao2 kinase domain: activation and specifity of a ste20p map3k
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: serine/threonine protein kinase tao2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (309 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1u9i
Crystal structure of circadian clock protein kaic with phosp sites
Source: Synechococcus elongatus. Organism_taxid: 1140. Strain: pcc 7942. Gene: kaic. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (484 residues) CATH domains: 3.40.50.300 3.40.50.300
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1uf0
Solution structure of the n-terminal dcx domain of human doublecortin-like kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna hh00177. Other_details: cell-free protein synthesis
Chain: A (116 residues) CATH domain: 3.10.20.230
1uix
Coiled-coil structure of the rhoa-binding domain in rho- kinase
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (69 residues) CATH domain: 1.20.5.730
1ukx
Solution structure of the rwd domain of mouse gcn2
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 2900069k12. Other_details: cell-free protein synthesis
Chain: A (137 residues) CATH domain: 3.10.110.10
1ul7
Solution structure of kinase associated domain 1 of mouse map/microtubule affinity-regulating kinase 3
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 1600015g02, mark3, emk2, mpk10. Other_details: cell-free protein synthesis
Chain: A (102 residues) CATH domain: 3.30.310.80
1ung
Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (288 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ALH is 42.42% similar to enzyme product ADP
1unh
Structural mechanism for the inhibition of cdk5-p25 by roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1unl
Structural mechanism for the inhibition of cd5-p25 from the roscovitine, aloisine and indirubin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (292 residues) CATH domains: 3.30.200.20 1.10.510.10
1unp
Crystal structure of the pleckstrin homology domain of pkb alpha
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21.
Chain: A (119 residues) CATH domain: 2.30.29.30
1unq
High resolution crystal structure of the pleckstrin homology domain of protein kinase b/akt bound to ins (1,3,4,5)-tetrakisphophate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21.
Chain: A (119 residues) CATH domain: 2.30.29.30
1unr
Crystal structure of the ph domain of pkb alpha in complex with a sulfate molecule
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21.
Chain: A (113 residues) CATH domain: 2.30.29.30
1uti
Mona/gads sh3c in complex with hpk derived peptide
Source: Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 10090
Chain: D (16 residues)
1uu3
Structure of human pdk1 kinase domain in complex with ly333531
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (278 residues) CATH domains: 1.10.510.10 3.30.200.20
1uu7
Structure of human pdk1 kinase domain in complex with bim-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (282 residues) CATH domains: 1.10.510.10 3.30.200.20
1uu8
Structure of human pdk1 kinase domain in complex with bim-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (279 residues) CATH domains: 1.10.510.10 3.30.200.20
1uu9
Structure of human pdk1 kinase domain in complex with bim-3
Source: Spodoptera frugiperda. Fall armyworm. Organism_taxid: 7108. Cell_line: sf21. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (277 residues) CATH domains: 1.10.510.10 3.30.200.20
1uv5
Glycogen synthase kinase 3 beta complexed with 6-bromoindirubin-3'-oxime
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: insect cells.
Chain: A (349 residues) CATH domains: 3.30.200.20 1.10.510.10
1uvr
Structure of human pdk1 kinase domain in complex with bim-8
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf21. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: baculovirus infected
Chain: A (285 residues) CATH domains: 1.10.510.10 3.30.200.20
1uwh
The complex of wild type b-raf and bay439006
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1uwj
The complex of mutant v599e b-raf and bay439006
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (264 residues) CATH domains: 3.30.200.20 1.10.510.10
1v1c
Solution structure of the sh3 domain of obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Tissue: muscle. Cell: myocyte. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (68 residues) CATH domain: 2.30.30.40
1v5s
Solution structure of kinase associated domain 1 of mouse map/microtubule affinity-regulating kinase 3
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 1600015g02. Other_details: cell-free protein synthesis
Chain: A (126 residues) CATH domain: 3.30.310.80
1v9v
Solution structure of putative domain of human kiaa0561 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kazusa cdna hh01676. Other_details: cell-free protein synthesis
Chain: A (114 residues) CATH domain: 1.20.1480.20
1vzo
The structure of the n-terminal kinase domain of msk1 reveals a novel autoinhibitory conformation for a dual kinase protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (319 residues) CATH domains: 3.30.200.20 1.10.510.10
1w1d
Crystal structure of the pdk1 pleckstrin homology (ph) domain bound to inositol (1,3,4,5)-tetrakisphosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (144 residues) CATH domain: 2.30.29.30
1w1g
Crystal structure of the pdk1 pleckstrin homology (ph) domain bound to dic4-phosphatidylinositol (3,4,5)- trisphosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (144 residues) CATH domain: 2.30.29.30
1w1h
Crystal structure of the pdk1 pleckstrin homology (ph) domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (147 residues) CATH domain: 2.30.29.30
1w1n
The solution structure of the fatc domain of the protein kinase tor1 from yeast
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (33 residues)
1waa
Ig27 protein domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Chains: A, B, C, D, E, F (92 residues) CATH domain: 2.60.40.10
1wak
X-ray structure of srpk1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (353 residues) CATH domains: 3.30.200.20 1.10.510.10
1wbp
Srpk1 bound to 9mer docking motif peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1wfw
Solution structure of sh3 domain of mouse kalirin-9a protein
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 2210407g14. Other_details: cell-free protein synthesis
Chain: A (74 residues) CATH domain: 2.30.30.40
1wh4
Solution structure of the death domain of interleukin-1 receptor-associated kinase4 (irak4) from mus musculus
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 9330209d03. Other_details: cell-free protein synthesis
Chain: A (127 residues) CATH domain: 1.10.533.10
1wit
Twitchin immunoglobulin superfamily domain (igsf module) (ig 18'), nmr, minimized average structure
Source: Caenorhabditis elegans. Organism_taxid: 6239. Organ: body wall muscle. Tissue: muscle a-band. Cell: muscle cell. Gene: unc-22. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (93 residues) CATH domain: 2.60.40.10
1wiu
Twitchin immunoglobulin superfamily domain (igsf module) (ig 18'), nmr, 30 structures
Source: Caenorhabditis elegans. Organism_taxid: 6239. Organ: body wall muscle. Tissue: muscle a-band. Cell: muscle cell. Gene: unc-22. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (93 residues) CATH domain: 2.60.40.10
1wmk
Human death-associated kinase drp-1, mutant s308d d40
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, E, C, B, F, D, H, G (303 residues) CATH domains: 3.30.200.20 1.10.510.10 1.20.5.460
1wrz
Calmodulin complexed with a peptide from a human death-assoc protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: the peptide was chemically synthesized. The of the peptide is naturally found in homo sapiens (human).
Chain: B (19 residues)
1wt6
Coiled-coil domain of dmpk
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, D (65 residues) CATH domain: 1.20.5.340
1wvw
Crystal structures of kinase domain of dap kinase in complex with small molecular inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
1wvx
Crystal structures of kinase domain of dap kinase in complex with small molecular inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
1wvy
Crystal structures of kinase domain of dap kinase in complex with small molecular inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
1wxm
Solution structure of the n-terminal ras-binding domain (rbd) in human a-raf kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: araf1. Other_details: cell-free protein synthesis
Chain: A (86 residues) CATH domain: 3.10.20.90
1x48
Solution structure of the second dsrm domain in interferon- induced, double-stranded RNA-activated protein kinase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: prkr, eif2ak2, pkr, tik. Other_details: cell free protein synthesis
Chain: A (88 residues) CATH domain: Unassigned
1x49
Solution structure of the first dsrm domain in interferon- induced, double-stranded RNA-activated protein kinase
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: prkr, eif2ak2, pkr, tik. Other_details: cell free protein synthesis
Chain: A (97 residues) CATH domain: 3.30.160.20
1x6a
Solution structures of the second lim domain of human lim- kinase 2 (limk2)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: limk2. Other_details: cell-free protein synthesis
Chain: A (81 residues) CATH domain: 2.10.110.10
1xqz
Crystal structure of hpim-1 kinase at 2.1 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
1xr1
Crystal structure of hpim-1 kinase in complex with amp-pnp at 2.1 a resolution
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1xte
Crystal structure of cisk-px domain
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: cisk. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (116 residues) CATH domain: 3.30.1520.10
1xtn
Crystal structure of cisk-px domain with sulfates
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: sgkl, cisk, sgk3. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (111 residues) CATH domain: 3.30.1520.10
1xws
Crystal structure of the human pim1 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
1y74
Solution structure of mlin-2/mlin-7 l27 domain complex
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: B, D (50 residues) CATH domain: 1.10.287.650
1y8g
Catalytic and ubiqutin-associated domains of mark2/par-1: inactive double mutant with selenomethionine
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mark2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
1ya5
Crystal structure of the titin domains z1z2 in complex with
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (198 residues) CATH domains: 2.60.40.10 2.60.40.10
1ygo
Solution structure of the pelle death domain
Source: Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: pll. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (110 residues) CATH domain: 1.10.533.10
1yhs
Crystal structure of pim-1 bound to staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
1yhv
Crystal structure of pak1 kinase domain with two point mutations (k299r, t423e)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pak1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
1yhw
Crystal structure of pak1 kinase domain with one point mutations (k299r)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pak1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
1yi3
Crystal structure of pim-1 bound to ly294002
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
1yi4
Structure of pim-1 bound to adenosine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADN is 70.00% similar to enzyme product ADP
1yr5
1.7-a structure of calmodulin bound to a peptide from dap ki
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: B (19 residues)
1yrp
Catalytic domain of human zip kinase phosphorylated at thr26
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (276 residues) CATH domains: 3.30.200.20 1.10.510.10
1ywv
Crystal structures of proto-oncogene kinase pim1: a target o somatic hypermutations in diffuse large cell lymphoma
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
1yxs
Crystal structure of kinase pim1 with p123m mutation
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
1yxt
Crystal structure of kinase pim1 in complex with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
1yxu
Crystal structure of kinase pim1 in complex with amp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B, C, D (273 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
1yxv
Crystal structure of kinase pim1 in complex with 3,4-dihydro methylquinolin-2(1h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group LI6 is 46.43% similar to enzyme product ADP
1yxx
Crystal structure of kinase pim1 in complex with (3e)-3-[(4- hydroxyphenyl)imino]-1h-indol-2(3h)-one
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
1z5m
Crystal structure of n1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylc amino]phenyl]amino]-4-pyrimidinyl]amino]propyl]-2,2- dimethylpropanediamide complexed with human pdk1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdpk1, pdk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
1z9x
Human drp-1 kinase, w305s s308a d40 mutant, crystal form wit monomers in the asymmetric unit
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: dapk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C (303 residues) CATH domains: 3.30.200.20 1.10.510.10
1zao
Crystal structure of a.Fulgidus rio2 kinase complexed with atp and manganese ions
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Gene: rio2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (271 residues) CATH domains: 1.10.10.10 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1zar
Crystal structure of a.Fulgidus rio2 kinase complexed with adp and manganese ions
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Gene: rio2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (267 residues) CATH domains: 1.10.10.10 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1zl8
Nmr structure of l27 heterodimer from c. Elegans lin-7 and h lin-2 scaffold proteins
Source: Caenorhabditis elegans. Organism_taxid: 6239. Gene: lin7. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Homo sapiens. Human. Organism_taxid: 9606. Gene: cask, lin2.
Chain: B (54 residues) CATH domain: 1.10.287.650
1zlt
Crystal structure of chk1 complexed with a hymenaldisine analog
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1, chk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
1zmu
Catalytic and ubiqutin-associated domains of mark2/par-1: wild type
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mark2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (293 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
1zmv
Catalytic and ubiqutin-associated domains of mark2/par-1: k8
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mark2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (293 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
1zmw
Catalytic and ubiqutin-associated domains of mark2/par-1: t208a/s212a inactive double mutant
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: mark2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
1zoe
Crystal structure of protein kinase ck2 in complex with tbb- derivatives inhibitors
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (325 residues) CATH domains: 1.10.510.10 3.30.200.20
1zog
Crystal structure of protein kinase ck2 in complex with tbb- derivatives
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (325 residues) CATH domains: 1.10.510.10 3.30.200.20
1zoh
Crystal structure of protein kinase ck2 in complex with tbb- derivatives inhibitors
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (326 residues) CATH domains: 1.10.510.10 3.30.200.20
1zp9
Crystal structure of full-legnth a.Fulgidus rio1 serine kina to atp and mn2+ ions.
Source: Archaeoglobus fulgidus. Organism_taxid: 224325. Strain: dsm 4304. Gene: rio1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (245 residues)
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1zsg
Beta pix-sh3 complexed with an atypical peptide from alpha- pak
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: arhgef7, cool1, kiaa0142, p85spr, pak3bp, pixb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the peptide is naturally found in homo sapiens
Chain: B (22 residues)
1ztf
Crystal structure of a.Fulgidus rio1 serine protein kinase
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Gene: rio1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (253 residues)
Bound ligand:   Het Group XYA is 70.00% similar to enzyme product ADP
1zth
Crystal structure of a.Fulgidus rio1 serine protein kinase bound to adp and manganese ion
Source: Archaeoglobus fulgidus. Organism_taxid: 2234. Gene: rio1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (245 residues)
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
1zuz
Calmodulin in complex with a mutant peptide from human drp-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide, mutation s308d, the seque the peptide: calmodulin-binding domain is naturally found i sapiens.
Chain: B (19 residues)
1zws
Crystal structure of the catalytic domain of human drp-1 kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (278 residues) CATH domains: 3.30.200.20 1.10.510.10
1zxe
Crystal structure of eif2alpha protein kinase gcn2: d835n in mutant in apo form
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gcn2, aas1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F (269 residues) CATH domains: 3.30.200.20 1.10.510.10
1zy4
Crystal structure of eif2alpha protein kinase gcn2: r794g hyperactivating mutant in apo form.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gcn2, aas1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domains: 3.30.200.20 1.10.510.10
1zy5
Crystal structure of eif2alpha protein kinase gcn2: r794g hyperactivating mutant complexed with amppnp.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gcn2, aas1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (271 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
1zyc
Crystal structure of eif2alpha protein kinase gcn2: wild- type in apo form.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gcn2, aas1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (261 residues) CATH domains: 3.30.200.20 1.10.510.10
1zyd
Crystal structure of eif2alpha protein kinase gcn2: wild- type complexed with atp.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: gcn2, aas1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (270 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
1zys
Co-crystal structure of checkpoint kinase chk1 with a pyrrolo-pyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1, chk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes
Chain: A (271 residues) CATH domains: 3.30.200.20 1.10.510.10
2a19
Pkr kinase domain- eif2alpha- amp-pnp complex.
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sui2, tif211. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chains: B, C (264 residues) CATH domains: 3.30.200.20 1.10.510.10
2a1a
Pkr kinase domain-eif2alpha complex
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: sui2, tif211. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606.
Chain: B (270 residues) CATH domains: 3.30.200.20 1.10.510.10
2a27
Human drp-1 kinase, w305s s308a d40 mutant, crystal form wit monomers in the asymmetric unit
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (304 residues) CATH domains: 3.30.200.20 1.10.510.10
2a2a
High-resolution crystallographic analysis of the autoinhibit conformation of a human death-associated protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (304 residues) CATH domains: 3.30.200.20 1.10.510.10
2a38
Crystal structure of the n-terminus of titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C (194 residues) CATH domains: 2.60.40.10 2.60.40.10
2a4z
Crystal structure of human pi3kgamma complexed with as604850
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (812 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2a5u
Crystal structure of human pi3kgamma complexed with as605240
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (839 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2a9i
Molecular structure of the interleukin-1 receptor- associated kinase-4 death domain
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: irak4. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (105 residues) CATH domain: 1.10.533.10
2aao
Regulatory apparatus of calcium dependent protein kinase fro arabidopsis thaliana
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: ak1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (147 residues)
2ac3
Structure of human mnk2 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
2ac5
Structure of human mnk2 kinase domain mutant d228g
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2ayp
Crystal structure of chk1 with an indol inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1, chk1
Chain: A (268 residues) CATH domains: 3.30.200.20 1.10.510.10
2be1
Structure of the compact lumenal domain of yeast ire1
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ire1, ern1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: co-crystallized peptide of unknown origin an sequence
Chains: A, B (301 residues)
2bfx
Mechanism of aurora-b activation by incenp and inhibition by hesperadin.
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (271 residues) CATH domains: 3.30.200.20 1.10.510.10
2bfy
Complex of aurora-b with incenp and hesperadin.
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2bik
Human pim1 phosphorylated on ser261
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2bil
The human protein kinase pim1 in complex with its consensus peptide pimtide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606
Chain: B (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2biy
Structure of pdk1-s241a mutant kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-21.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2bk8
M1 domain from titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (97 residues) CATH domain: 2.60.40.10
2bmc
Aurora-2 t287d t288d complexed with pha-680632
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: insect cells. Expression_system_cell_line: high five.
Chains: A, B, C, D, E, F (256 residues) CATH domains: 3.30.200.20 1.10.510.10
2br1
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2brb
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2brg
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (257 residues) CATH domains: 3.30.200.20 1.10.510.10
2brh
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (257 residues) CATH domains: 3.30.200.20 1.10.510.10
2brm
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (263 residues) CATH domains: 3.30.200.20 1.10.510.10
2brn
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (268 residues) CATH domains: 3.30.200.20 1.10.510.10
2bro
Structure-based design of novel chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2buj
Crystal structure of the human serine-threonine kinase 16 in complex with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: rosetta ii.
Chains: A, B (291 residues) CATH domains: Unassigned 1.10.510.10
2bva
Crystal structure of the human p21-activated kinase 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r (phage resistant).
Chains: A, B (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2bzh
Crystal structure of the human pim1 in complex with a ruthenium organometallic ligand ru1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B (275 residues) CATH domains: 3.30.200.20 1.10.510.10
2bzi
Crystal structure of the human pim1 in complex with a ruthenium organometallic ligand ru2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2bzj
Crystal structure of the human pim1 in complex with a ruthenium organometallic ligand ru3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2bzk
Crystal structure of the human pim1 in complex with amppnp and pimtide
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B (268 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2c30
Crystal structure of the human p21-activated kinase 6
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2c3i
Crystal structure of human pim1 in complex with imidazopyridazin i
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: B (266 residues) CATH domains: 3.30.200.20 1.10.510.10
2c3j
Identification of a buried pocket for potent and selective inhibition of chk1: prediction and verification
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (257 residues) CATH domains: 3.30.200.20 1.10.510.10
2c3k
Identification of a buried pocket for potent and selective inhibition of chk1: prediction and verification
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (262 residues) CATH domains: 3.30.200.20 1.10.510.10
2c3l
Identification of a buried pocket for potent and selective inhibition of chk1: prediction and verification
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2c47
Structure of casein kinase 1 gamma 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: de3.
Chains: A, B, C, D (289 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group 5ID is 62.07% similar to enzyme product ADP
2c6d
Aurora a kinase activated mutant (t287d) in complex with adpnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (255 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 92.00% similar to enzyme product ADP
2c6e
Aurora a kinase activated mutant (t287d) in complex with a 5-aminopyrimidinyl quinazoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2cdz
Crystal structure of the human p21-activated kinase 4 in complex with cgp74514a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2cgu
Identification of chemically diverse chk1 inhibitors by receptor-based virtual screening
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (263 residues) CATH domains: 3.30.200.20 1.10.510.10
2cgv
Identification of chemically diverse chk1 inhibitors by receptor-based virtual screening
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
2cgw
Identification of chemically diverse chk1 inhibitors by receptor-based virtual screening
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (262 residues) CATH domains: 3.30.200.20 1.10.510.10
2cgx
Identification of chemically diverse chk1 inhibitors by receptor-based virtual screening
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2chl
Structure of casein kinase 1 gamma 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: de3.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2chw
A pharmacological map of the pi3-k family defines a role for p110 alpha in signaling: the structure of complex of phosphoinositide 3-kinase gamma with inhibitor pik-39
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (840 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2chx
A pharmacological map of the pi3-k family defines a role for p110alpha in signaling: the structure of complex of phosphoinositide 3-kinase gamma with inhibitor pik-90
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (843 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2chz
A pharmacological map of the pi3-k family defines a role for p110alpha in signaling: the structure of complex of phosphoinositide 3-kinase gamma with inhibitor pik-93
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (840 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2cke
Human death-associated drp-1 kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss.
Chains: A, B, C, D (301 residues) CATH domains: 3.30.200.20 1.10.510.10
2cl1
Human nek2 kinase with pyrrole-indolinone ligand
Source: Expressed in: escherichia coli. Homo sapiens. Human
Chain: A (250 residues) CATH domains: 3.30.200.20 1.10.510.10
2cmw
Structure of human casein kinase 1 gamma-1 in complex with 2-(2-hydroxyethylamino)-6-(3-chloroanilino)-9- isopropylpurine (casp target)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group OLP is 41.67% similar to enzyme product ADP
2cn5
Crystal structure of human chk2 in complex with adp
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: human cdna library
Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2cn8
Crystal structure of human chk2 in complex with debromohymenialdisine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: human cdna library
Chain: A (266 residues) CATH domains: 3.30.200.20 1.10.510.10
2cos
Solution structure of rsgi ruh-038, a uba domain from mouse lats2 (large tumor suppressor homolog 2)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: av362185. Other_details: cell-free protein synthesis
Chain: A (54 residues) CATH domain: Unassigned
2cr6
Solution structure of the ig domain (2998-3100) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa1556. Other_details: cell free protein synthesis
Chain: A (115 residues) CATH domain: 2.60.40.10
2csn
Binary complex of casein kinase-1 with cki7
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10
2dku
Solution structure of the third ig-like domain of human kiaa1556 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa1556. Expressed in: cell free synthesis. Other_details: cell free protein synthesis
Chain: A (103 residues) CATH domain: 2.60.40.10
2dm7
Solution structure of the 14th ig-like domain of human kiaa1556 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa1556. Expressed in: cell free synthesis. Other_details: cell free protein synthesis
Chain: A (108 residues) CATH domain: 2.60.40.10
2dwb
Aurora-a kinase complexed with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Other_details: cell free protein synthesis
Chain: A (262 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
2e7b
Solution structure of the 6th ig-like domain from human kiaa1556
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (103 residues) CATH domain: 2.60.40.10
2e9n
Structure of h-chk1 complexed with a767085
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2e9o
Structure of h-chk1 complexed with aa582939
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2e9p
Structure of h-chk1 complexed with a771129
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2e9u
Structure of h-chk1 complexed with a780125
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group A25 is 41.00% similar to enzyme product ADP
2e9v
Structure of h-chk1 complexed with a859017
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (268 residues) CATH domains: 3.30.200.20 1.10.510.10
2edf
Solution structure of the second ig-like domain(2826-2915) from human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (103 residues) CATH domain: 2.60.40.10
2edh
Solution structure of the pdz domain (3614- 3713 ) from huma
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Expressed in: cell free protein synthesis.
Chain: A (113 residues) CATH domain: 2.60.40.10
2edl
Solution structure of the ig-like domain (3801-3897) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (110 residues) CATH domain: 2.60.40.10
2edq
Solution structure of the ig-like domain (3713-3806) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (107 residues) CATH domain: 2.60.40.10
2edr
Solution structure of the ig-like domain (3361-3449) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn, kiaa1556, kiaa1639. Other_details: cell free protein synthesis
Chain: A (102 residues) CATH domain: 2.60.40.10
2edt
Solution structure of the ig-like domain (3449-3537) from human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (102 residues) CATH domain: 2.60.40.10
2edw
Solution structure of the i-set domain (3537-3630) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell free protein synthesis
Chain: A (107 residues) CATH domain: 2.60.40.10
2ehb
The structure of thE C-terminal domain of the protein kinase bound to the calcium sensor atsos3
Source: Arabidopsis thaliana. Thale cress. Organism_taxid: 3702. Gene: sos3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sos2.
Chain: D (126 residues) CATH domain: 3.30.310.80
2enq
Solution structure of the c2 domain from human pi3-kinase p110 subunit alpha
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3ca. Other_details: cell free protein synthesis
Chain: A (158 residues) CATH domain: 2.60.40.150
2eny
Solution structure of the ig-like domain (2735-2825) of human obscurin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell-free protein synthesis
Chain: A (104 residues) CATH domain: 2.60.40.10
2eo1
Solution structure of the ig domain of human obscn protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: obscn. Other_details: cell-free protein synthesis
Chain: A (102 residues) CATH domain: 2.60.40.10
2esm
Crystal structure of rock 1 bound to fasudil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rock1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (400 residues) CATH domains: 3.30.200.20 1.10.510.10
2etk
Crystal structure of rock 1 bound to hydroxyfasudil
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rock1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (400 residues) CATH domains: 3.30.200.20 1.10.510.10
2etr
Crystal structure of rock i bound to y-27632
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rock1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (400 residues) CATH domains: 3.30.200.20 1.10.510.10
2f2u
Crystal structure of the rho-kinase kinase domain
Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: rock2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (386 residues) CATH domains: 3.30.200.20 1.10.510.10
2f57
Crystal structure of the human p21-activated kinase 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2f8v
Structure of full length telethonin in complex with the n-te titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tcap. Expression_system_taxid: 562
Chains: A, B, C, D (194 residues) CATH domains: 2.60.40.10 2.60.40.10
2fap
The structure of the immunophilin-immunosuppressant fkbp12-( ethoxy rapamycin complex interacting with huma
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: bl21. Gene: human hippocampal cdna library (clontech, palo alto, expressed in: escherichia coli. Expression_system_taxid: 562. Gene: human hippocampal cdna library. Expressed in: escherichia coli bl21(de3).
Chain: B (94 residues) CATH domain: 1.20.120.150
2fb8
Structure of the b-raf kinase domain bound to sb-590885
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: braf, braf1, rafb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9.
Chains: A, B (259 residues) CATH domains: 3.30.200.20 1.10.510.10
2fh9
Structure and dimerization of the kinase domain from yeast s
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: snf1, cat1, ccr1, glc2, pas14. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (255 residues) CATH domains: 3.30.200.20 1.10.510.10
2fum
Catalytic domain of protein kinase pknb from mycobacterium tuberculosis in complex with mitoxantrone
Source: Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Strain: h37rv. Gene: pknb. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (263 residues) CATH domains: 3.30.200.20 1.10.510.10
2gaq
Nmr solution structure of the frb domain of mtor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: frap1, frap, frap2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (100 residues) CATH domain: 1.20.120.150
2gbl
Crystal structure of full length circadian clock protein kai phosphorylation sites
Source: Synechococcus elongatus. Organism_taxid: 1140. Strain: pcc 7942. Gene: kaic. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D, E, F (506 residues) CATH domains: 3.40.50.300 3.40.50.300
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2gcd
Tao2 kinase domain-staurosporine structure
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: tao2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
Chains: A, B (309 residues) CATH domains: 3.30.200.20 1.10.510.10
2gdo
4-(aminoalkylamino)-3-benzimidazole-quinolinones as potent chk1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2ghg
H-chk1 complexed with a431994
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2gqh
Solution structure of the 15th ig-like domain of human kiaa1556 protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa1556. Other_details: cell free protein synthesis
Chain: A (107 residues) CATH domain: 2.60.40.10
2h34
Apoenzyme crystal structure of the tuberculosis serine/threo kinase, pkne
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: pkne. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (243 residues) CATH domains: 3.30.200.20 1.10.510.10
2h6d
Protein kinase domain of the human 5'-amp-activated protein kinase catalytic subunit alpha-2 (ampk alpha-2 chain)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: prkaa2, ampk, ampk2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (256 residues) CATH domains: 3.30.200.20 1.10.510.10
2h7o
Crystal structure of the rho-gtpase binding domain of ypka
Source: Yersinia pseudotuberculosis. Organism_taxid: 633. Gene: ypka. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (270 residues) CATH domains: Unassigned Unassigned
2h7v
Co-crystal structure of ypka-rac1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mig5, rac1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Yersinia pseudotuberculosis. Organism_taxid: 633. Gene: ypka.
Chains: C, D (269 residues) CATH domains: Unassigned Unassigned
Bound ligand:   Het Group GDP is 96.43% similar to enzyme product ADP
2h9v
Structural basis for induced-fit binding of rho-kinase to th inhibitor y27632
Source: Bos taurus. Cattle. Organism_taxid: 9913. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (383 residues) CATH domains: 3.30.200.20 1.10.510.10
2hak
Catalytic and ubiqutin-associated domains of mark1/par-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mark1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (309 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
2hog
Crystal structure of chek1 in complex with inhibitor 20
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1, chk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2hw6
Crystal structure of mnk1 catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mknk1, mnk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (242 residues) CATH domains: 3.30.200.20 1.10.510.10
2hw7
Crystal structure of mnk2-d228g in complex with staurosporin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mknk2, mnk2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (271 residues) CATH domains: 3.30.200.20 1.10.510.10
2hxl
Crystal structure of chek1 in complex with inhibitor 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2hxq
Crystal structure of chek1 in complex with inhibitor 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2hy0
Crystal structure of chek1 in complex with inhibitor 22
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: chek1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10
2hy8
Pak1 complex with st2001
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pak1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: 1 (293 residues) CATH domains: 3.30.200.20 1.10.510.10
2hz6
The crystal structure of human ire1-alpha luminal domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (253 residues) CATH domain: Unassigned
2i3s
Bub3 complex with bub1 glebs motif
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: bub3, yor026w, or26.16. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: chemically synthesized peptide.
Chains: B, D, F (36 residues)
2ill
Anomalous substructure of titin-a168169
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (195 residues) CATH domains: 2.60.40.10 2.60.40.10
2iwi
Crystal structure of the human pim2 in complex with a ruthenium organometallic ligand ru1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21(de3) star.
Chains: A, B (244 residues) CATH domains: 3.30.200.20 1.10.510.10
2izr
Structure of casein kinase gamma 3 in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: de3.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2izs
Structure of casein kinase gamma 3 in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2izt
Structure of casein kinase gamma 3 in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group 23D is 45.45% similar to enzyme product ADP
2izu
Structure of casein kinase gamma 3 in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_cell_line: de3.
Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10
2j0i
Crystal structure of the human p21-activated kinase 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21de3.
Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10
2j2i
Crystal structure of the humab pim1 in complex with ly333531
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: bl21.
Chain: B (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2j4z
Structure of aurora-2 in complex with pha-680626
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five.
Chains: A, B (264 residues) CATH domains: 3.30.200.20 1.10.510.10
2j50
Structure of aurora-2 in complex with pha-739358
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five.
Chains: A, B (250 residues) CATH domains: 3.30.200.20 1.10.510.10
2j51
Crystal structure of human ste20-like kinase bound to 5- amino-3-((4-(aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2,4-triazole-1-carbothioamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
2j7t
Crystal structure of human serine threonine kinase-10 bound to su11274
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2j8h
Structure of the immunoglobulin tandem repeat a168-a169 of titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (195 residues) CATH domains: 2.60.40.10 2.60.40.10
2j8o
Structure of the immunoglobulin tandem repeat of titin a168- a169
Source: Homo sapiens. Human. Organism_taxid: 9606. Organ: heart. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (196 residues) CATH domains: 2.60.40.10 2.60.40.10
2j90
Crystal structure of human zip kinase in complex with a tetracyclic pyridone inhibitor (pyridone 6)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3.
Chains: A, B (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2ja0
Crystal structure of human ste20-like kinase bound to 4-(4- (5-cyclopropyl-1h-pyrazol-3-ylamino)-quinazolin-2-ylamino) -benzonitrile
Source: Expressed in: escherichia coli. Homo sapiens. Human
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2jav
Human kinase with pyrrole-indolinone ligand
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (253 residues) CATH domains: 3.30.200.20 1.10.510.10
2jbo
Protein kinase mk2 in complex with an inhibitor (crystal form-1, soaking)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10
2jbp
Protein kinase mk2 in complex with an inhibitor (crystal form-2, co-crystallization)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F, G, H, I, J, K, L (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2jd5
Sky1p bound to npl3p-derived substrate peptide
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes
Chains: A, B (353 residues) CATH domains: 3.30.200.20 1.10.510.10
2jdo
Structure of pkb-beta (akt2) complexed with isoquinoline-5- sulfonic acid (2-(2-(4-chlorobenzyloxy) ethylamino)ethyl) amide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 9606
Chain: A (315 residues) CATH domains: 3.30.200.20 1.10.510.10
2jdr
Structure of pkb-beta (akt2) complexed with the inhibitor a- 443654
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 9606
Chain: A (317 residues) CATH domains: 3.30.200.20 1.10.510.10
2jfl
Crystal structure of human ste20-like kinase ( diphosphorylated form) bound to 5- amino-3-((4-( aminosulfonyl)phenyl)amino)-n-(2,6- difluorophenyl)-1h-1,2, 4-triazole-1-carbothioamide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
2jfm
Crystal structure of human ste20-like kinase (unliganded form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10
2jld
Extremely tight binding of ruthenium complex to glycogen synthase kinase 3
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes
Chains: A, B (349 residues) CATH domains: 3.30.200.20 1.10.510.10
2jo8
Solution structure of c-terminal domain of human mammalian sterile 20-like kinase 1 (mst1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: stk4, mst1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (51 residues) CATH domain: Unassigned
2jqj
Nmr structure of yeast dun1 fha domain
Source: Saccharomyces cerevisiae. Yeast. Gene: dun1. Expressed in: escherichia coli.
Chain: A (141 residues) CATH domain: 2.60.200.20
2jql
Nmr structure of the yeast dun1 fha domain in complex with a doubly phosphorylated (pt) peptide derived from rad53 scd1
Source: Saccharomyces cerevisiae. Yeast. Gene: dun1. Expressed in: escherichia coli. Synthetic: yes
Chain: A (141 residues) CATH domain: 2.60.200.20
2kbx
Solution structure of ilk-pinch complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ilk, ilk1, ilk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: lims1, pinch, pinch1.
Chain: A (171 residues) CATH domain: 1.25.40.20
2kio
Nmr structure of the oxidized yeast tor1 fatc domain bound to dpc micelles at 318k
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: drr1, j1803, tor1, yjr066w. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: rosetta (de3).
Chain: A (33 residues)
2kit
The solution struture of the reduced yeast tor1 fatc domain bound to dpc micelles at 298k
Source: Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: drr1, j1803, tor1, yjr066w. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: rosetta (de3).
Chain: A (33 residues)
2kqf
Solution structure of mast205-pdz complexed with thE C-termi rabies virus g protein
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mast205. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide
Chain: A (96 residues) CATH domain: 2.30.42.10
2kr9
Kalirin dh1 nmr structure
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Organ: brain. Gene: kalrn, duo, hapip. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (190 residues) CATH domain: 1.20.900.10
2kty
Solution structure of human vaccinia related kinase-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vrk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domains: Unassigned 1.10.510.10
2kud
Nmr structure of the pasta domain 1 and 2 of mycobacterium tuberculosis of pknb
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0014c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (137 residues) CATH domains: Unassigned Unassigned
2kue
Nmr structure of the pasta domain 2 and 3 of mycobacterium tuberculosis of pknb
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0014c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (135 residues) CATH domains: Unassigned Unassigned
2kuf
Nmr structure of the pasta domain 3 and 4 of mycobacterium tuberculosis of pknb
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0014c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (136 residues) CATH domains: Unassigned Unassigned
2kui
Nmr structure of the pasta domain of mycobacterium tuberculo pknb
Source: Mycobacterium tuberculosis. Organism_taxid: 83332. Strain: h37rv. Gene: rv0014c. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (272 residues) CATH domains: Unassigned Unassigned Unassigned Unassigned
2kul
Solution structure of human vaccinia related kinase 1(vrk1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vrk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (360 residues) CATH domains: Unassigned 1.10.510.10
2kyl
Solution structure of mast2-pdz complexed with thE C-terminu
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: A (96 residues) CATH domain: 2.30.42.10
2kym
Solution structure of the bem1p sh3-ci domain from l.Elongis complex with ste20p peptide
Source: Lodderomyces elongisporus. Yeast. Organism_taxid: 379508. Strain: nrrl yb-4239. Gene: lelg_04233. Expressed in: escherichia coli. Expression_system_taxid: 511693. Synthetic: yes. Saccharomyces cerevisiae.
Chain: B (16 residues)
2l05
Solution nmr structure of the ras-binding domain of serine/t protein kinase b-raf from homo sapiens, northeast structura consortium target hr4694f
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: braf, braf1, rafb1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (86 residues) CATH domain: 3.10.20.90
2lah
Solution nmr structure of mitotic checkpoint serine/threonin kinase bub1 n-terminal domain from homo sapiens, northeast genomics consortium target hr5460a (methods development)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: bub1, bub1l. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (160 residues) CATH domain: Unassigned
2lav
Nmr solution structure of human vaccinia-related kinase 1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vrk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (361 residues) CATH domains: Unassigned 1.10.510.10
2lcs
Yeast nbp2p sh3 domain in complex with a peptide from ste20p
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: nbp2, ydr162c. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Saccharomyces cerevisiae s288c.
Chain: B (16 residues)
2lru
Solution structure of the wnk1 autoinhibitory domain
Source: Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: wnk1, hsn2, prkwnk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (98 residues) CATH domain: Unassigned
2ltu
Solution structure of autoinhibitory domain of human amp-act protein kinase catalytic subunit
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (62 residues) CATH domain: Unassigned
2m9x
Solution nmr structure of microtubule-associated serine/thre protein kinase 1 from homo sapiens, northeast structural ge consortium (nesg) target hr9151a
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0973, mast1, sast. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (112 residues) CATH domain: 1.20.1480.20
2np8
Structural basis for the inhibition of aurora a kinase by a novel class of high affinity disubstituted pyrimidine inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aik. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (256 residues) CATH domain: 3.30.200.20
2npu
The solution structure of the rapamycin-binding domain of mtor (frb)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (101 residues) CATH domain: 1.20.120.150
2nru
Crystal structure of irak-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: irak4. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C, D (295 residues) CATH domains: 3.30.200.20 1.10.510.10
2nry
Crystal structure of irak-4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C, D (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2nz8
N-terminal dhph cassette of trio in complex with nucleotide- free rac1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: trio.
Chain: B (279 residues) CATH domains: 1.20.900.10 2.30.29.30
2nzi
Crystal structure of domains a168-a170 from titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ttn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (292 residues) CATH domains: 2.60.40.10 2.60.40.10 2.60.40.10
2o3p
Crystal structure of pim1 with quercetin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2o5k
Crystal structure of gsk3beta in complex with a benzoimidazol inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: A (350 residues) CATH domains: 3.30.200.20 1.10.510.10
2o63
Crystal structure of pim1 with myricetin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2o64
Crystal structure of pim1 with quercetagetin
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2o65
Crystal structure of pim1 with pentahydroxyflavone
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2o8y
Apo irak4 kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: irak4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2obj
Crystal structure of human pim-1 kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10
2odb
The crystal structure of human cdc42 in complex with the cri of human p21-activated kinase 6 (pak6)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc42. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes
Chain: B (35 residues)
Bound ligand:   Het Group GCP is 78.79% similar to enzyme product ADP
2oi4
Crystal structure of human pim1 in complex with fluorinated ruthenium pyridocarbazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chain: X (275 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group EPE is 40.00% similar to enzyme reactant protein
2oib
Crystal structure of irak4 kinase domain apo form
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: irak4. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C, D (283 residues) CATH domains: 3.30.200.20 1.10.510.10
2oic
Crystal structure of irak4 kinase domain complexed with staurosporine
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: irak4. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C, D (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2oid
Crystal structure of irak4 kinase domain complexed with amppnp
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: irak4. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469
Chains: A, B, C, D (266 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
2okr
Crystal structure of the p38a-mapkap kinase 2 heterodimer
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: this sequence occurs naturally in homo sapiens (humans)
Chains: C, F (24 residues)
2onl
Crystal structure of the p38a-mapkap kinase 2 heterodimer
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, mxi2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: mapkapk2.
Chains: C, D (317 residues) CATH domains: 3.30.200.20 1.10.510.10 4.10.1170.10
2oox
Crystal structure of the adenylate sensor from amp-activated kinase complexed with amp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Strain: 972. Atcc: 38366. Gene: ssp2, spcc74.03c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spcc1919.03c.
Chains: A, C (128 residues) CATH domain: Unassigned
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
2ooy
Crystal structure of the adenylate sensor from amp- activated protein kinase complexed with atp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Strain: 972. Atcc: 38366. Gene: ssp2, spcc74.03c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spcc1919.03c.
Chains: A, C (129 residues) CATH domain: Unassigned
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2ov2
The crystal structure of the human rac3 in complex with the domain of human p21-activated kinase 4 (pak4)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: pak4, kiaa1142.
Chains: I, J, K, L, M, N, O, P (34 residues)
Bound ligand:   Het Group GCP is 78.79% similar to enzyme product ADP
2ow3
Glycogen synthase kinase-3 beta in complex with bis- (indole)maleimide pyridinophane inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gsk3b
Chains: A, B (347 residues) CATH domains: 3.30.200.20 1.10.510.10
2oxd
Protein kinase ck2 in complex with tetrabromobenzoimidazole k17, k22 and k32 inhibitors
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (325 residues) CATH domains: 1.10.510.10 3.30.200.20
2oxx
Protein kinase ck2 in complex with tetrabromobenzoimidazole derivatives k17, k22 and k32
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (325 residues) CATH domains: 1.10.510.10 3.30.200.20
2oxy
Protein kinase ck2 in complex with tetrabromobenzoimidazole derivatives k17, k22 and k32
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (327 residues) CATH domains: 1.10.510.10 3.30.200.20
2oza
Structure of p38alpha complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Mus musculus. House mouse. Organism_taxid: 10090.
Chain: A (332 residues) CATH domains: 3.30.200.20 1.10.510.10 4.10.1170.10
2p3g
Crystal structure of a pyrrolopyridine inhibitor bound to mapkap kinase-2
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: X (282 residues) CATH domains: 3.30.200.20 1.10.510.10
2pe0
Crystal structure of human phosphoinositide-dependent protei (pdk1) 5-hydroxy-3-[1-(1h-pyrrol-2-yl)-eth-(z)-ylidene]-1,3 indol-2-one complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdpk1, pdk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2pe1
Crystal structure of human phosphoinositide-dependent protei (pdk1) {2-oxo-3-[1-(1h-pyrrol-2-yl)-eth-(z)-ylidene]-2,3-di indol-5-yl}-urea {bx-517} complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdpk1, pdk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2pe2
Crystal structure of human phosphoinositide-dependent protei (pdk1) 3-{5-[2-oxo-5-ureido-1,2-dihydro-indol-(3z)-ylidenem pyrrol-3-yl}-n-(2-piperidin-1-yl-ethyl)-benzamide complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdpk1, pdk1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2phk
The crystal structure of a phosphorylase kinase peptide subs complex: kinase substrate recognition
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Strain: new zealand white. Cell_line: bl21. Organ: skeletal. Tissue: skeletal muscle. Gene: phkg. Expressed in: escherichia coli bl21(de3).
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2pvh
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvj
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (327 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvk
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvl
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvm
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvn
Structure-based design of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase ck2
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
2pvr
Crystal structure of the catalytic subunit of protein kinase terminal deletion mutant 1-335) in complex with two sulfate
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1, ck2a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (328 residues) CATH domains: 1.10.510.10 3.30.200.20
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2pzi
Crystal structure of protein kinase pkng from mycobacterium tuberculosis in complex with tetrahydrobenzothiophene ax200
Source: Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: atcc25618. Gene: pkng. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (654 residues) CATH domain: 1.10.510.10
2pzy
Structure of mk2 complexed with compound 76
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mapkapk2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B, C, D (291 residues) CATH domains: 3.30.200.20 1.10.510.10
2q0n
Structure of human p21 activating kinase 4 (pak4) in complex consensus peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pak4, kiaa1142. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide
Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10
2qc6
Protein kinase ck2 in complex with dbc
Source: Zea mays. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (327 residues) CATH domains: 1.10.510.10 3.30.200.20
2qhm
Crystal structure of chek1 in complex with inhibitor 2a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (268 residues) CATH domains: 3.30.200.20 1.10.510.10
2qhn
Crystal structure of chek1 in complex with inhibitor 1a
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (268 residues) CATH domains: 3.30.200.20 1.10.510.10
2qlv
Crystal structure of the heterotrimer core of the s. Cerevisiae ampk homolog snf1
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: snf1, cat1, ccr1, glc2, pas14. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: sip2, spm2. Gene: snf4, cat3.
Chains: A, D (133 residues) CATH domain: 3.30.310.80
2qme
Crystal structure of human rac3 in complex with crib domain p21-activated kinase 1 (pak1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: rac3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide with the sequence of thE C domain of human pak1 protein
Chain: I (24 residues)
Bound ligand:   Het Group GCP is 78.79% similar to enzyme product ADP
2qnj
Kinase and ubiquitin-associated domains of mark3/par-1
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mark3, ctak1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, B (318 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
2qr1
Crystal structure of the adenylate sensor from amp-activated kinase in complex with adp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: ssp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (116 residues) CATH domain: Unassigned
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2qr7
2.0a x-ray structure of c-terminal kinase domain of p90 ribo kinase 2: se-met derivative
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: rps6ka3, rps6ka-rs1, rsk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2qr8
2.0a x-ray structure of c-terminal kinase domain of p90 ribo kinase 2 (rsk2)
Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: rps6ka3, rps6ka-rs1, rsk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10
2qrc
Crystal structure of the adenylate sensor from amp-activated kinase in complex with adp and amp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: ssp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (116 residues) CATH domain: Unassigned
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2qrd
Crystal structure of the adenylate sensor from amp-activated kinase in complex with adp and atp
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: ssp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (114 residues) CATH domain: Unassigned
Bound ligands:   Het Group ATP corresponds to enzyme reactant ATP
  Het Group ADP corresponds to enzyme product ADP
2qre
Crystal structure of the adenylate sensor from amp-activated kinase in complex with 5-aminoimidazole-4-carboxamide 1-bet ribofuranotide (zmp)
Source: Schizosaccharomyces pombe. Fission yeast. Organism_taxid: 4896. Gene: ssp2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chains: A, C (109 residues) CATH domain: Unassigned
Bound ligand:   Het Group AMZ is 75.00% similar to enzyme product ADP
2r0i
Crystal structure of a kinase mark2/par-1 mutant
Source: Rattus norvegicus. Organism_taxid: 10116. Gene: mark2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (300 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
2r0u
Crystal structure of chek1 in complex with inhibitor 54
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2r5t
Crystal structure of inactive serum and glucocorticoid- regulated kinase 1 in complex with amp-pnp
Source: Homo sapiens. Human. Gene: sgk, sgk1. Expressed in: baculovirus. Expression vector
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.00% similar to enzyme product ADP
2r7b
Crystal structure of the phosphoinositide-dependent kinase- 1 (pdk-1)catalytic domain bound to a dibenzonaphthyridine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pdpk1, pdk1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2r7i
Crystal structure of catalytic subunit of protein kinase ck2
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: ck2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D (322 residues) CATH domains: 1.10.510.10 3.30.200.20
2rd0
Structure of a human p110alpha/p85alpha complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pik3ca. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: pik3r1, grb1.
Chain: A (997 residues) CATH domains: 3.10.20.90 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2rik
I-band fragment i67-i69 from titin
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (283 residues) CATH domains: 2.60.40.10 2.60.40.10 2.60.40.10
2rio
Structure of the dual enzyme ire1 reveals the basis for catalysis and regulation of non-conventional splicing
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: ire1, ern1. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.
Chains: A, B (396 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2rjm
3ig structure of titin domains i67-i69 e-to-a mutated varian
Source: Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (283 residues) CATH domains: 2.60.40.10 2.60.40.10 2.60.40.10
2rkp
Crystal structure of the catalytic subunit of human protein kinase ck2 with 5,6-dichloro-1-beta-d- ribofuranosylbenzimidazole
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: csnk2a1 or ck2a1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Chain: A (334 residues) CATH domains: 1.10.510.10 3.30.200.20
2rov
The split ph domain of rock ii
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rock2. Expressed in: escherichia coli.
Chain: A (117 residues) CATH domain: 2.30.29.30
2row
The c1 domain of rock ii
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: rock2. Expressed in: escherichia coli.
Chain: A (84 residues) CATH domain: 3.30.60.20
2rpn
A crucial role for high intrinsic specificity in the function of yeast sh3 domains
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: B (18 residues)
2rq8
Solution nmr structure of titin i27 domain mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ttn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (98 residues) CATH domain: 2.60.40.10
2rqw
Solution structure of bem1p sh3ci domain complexed with ste2 peptide
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: B (24 residues)
2rse
Nmr structure of fkbp12-mtor frb domain-rapamycin complex st determined based on pcs
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: fkbp1a, fkbp1, fkbp12. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: mtor, frap, frap1, frap2, raft1, rapt1.
Chain: B (94 residues) CATH domain: 1.20.120.150
2rsv
Solution structure of human full-length vaccinia related kin (vrk1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vrk1. Expressed in: cell-free synthesis.
Chain: A (403 residues) CATH domain: Unassigned
2uv2
Crystal structure of human ste20-like kinase bound to 4-(4-( 5-cyclopropyl-1h-pyrazol-3-ylamino)-quinazolin-2-ylamino)- phenyl)-acetonitrile
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2uvm
Structure of pkbalpha ph domain in complex with a novel inositol headgroup surrogate, benzene 1,2,3,4- tetrakisphosphate
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (116 residues) CATH domain: 2.30.29.30
2uw9
Structure of pkb-beta (akt2) complexed with 4-(4-chloro- phenyl)-4-(4-(1h-pyrazol-4-yl)-phenyl)-piperidine
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Organism_taxid: 9606
Chain: A (317 residues) CATH domains: 3.30.200.20 1.10.510.10
2uzr
A transforming mutation in the pleckstrin homology domain of akt1 in cancer (akt1-ph_e17k)
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (113 residues) CATH domain: 2.30.29.30
2uzs
A transforming mutation in the pleckstrin homology domain of akt1 in cancer (akt1-ph_e17k)
Source: Homo sapiens. Human. Organism_taxid: 9606
Chain: A (119 residues) CATH domain: 2.30.29.30
2v1y
Structure of a phosphoinositide 3-kinase alpha adaptor- binding domain (abd) in a complex with the ish2 domain from p85 alpha
Source: Bos taurus. Bovine. Organism_taxid: 9913. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: chain a is the adaptor-binding domain from b p110 alpha. Homo sapiens. Human.
Chain: A (90 residues) CATH domain: 3.10.20.90
2v3s
Structural insights into the recognition of substrates and activators by the osr1 kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Chains: A, B (96 residues) CATH domain: 3.10.20.90
2v4l
Complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with pik-284
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (845 residues) CATH domains: 3.10.20.90 2.60.40.150 1.25.40.70 3.30.1010.10 1.10.1070.11
2v55
Mechanism of multi-site phosphorylation from a rock-i:rhoe complex structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, C (393 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group GTP is 96.00% similar to enzyme reactant ATP
2v62
Structure of vaccinia-related kinase 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (309 residues) CATH domains: 3.30.200.20 1.10.510.10
2v8q
Crystal structure of the regulatory fragment of mammalian ampk in complexes with amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
2v92
Crystal structure of the regulatory fragment of mammalian ampk in complexes with atp-amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2v9j
Crystal structure of the regulatory fragment of mammalian ampk in complexes with mg.Atp-amp
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2vd5
Structure of human myotonic dystrophy protein kinase in complex with the bisindoylmaleide inhibitor bim viii
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chains: A, B (390 residues) CATH domains: 3.30.200.20 1.10.510.10
2vgo
Crystal structure of aurora b kinase in complex with reversine inhibitor
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2vgp
Crystal structure of aurora b kinase in complex with a aminothiazole inhibitor
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B (266 residues) CATH domains: 3.30.200.20 1.10.510.10
2vki
Structure of the pdk1 ph domain k465e mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (140 residues) CATH domain: 2.30.29.30
2vrx
Structure of aurora b kinase in complex with zm447439
Source: Xenopus laevis. African clawed frog. Organism_taxid: 8355. Organism_taxid: 8355
Chains: A, B (269 residues) CATH domains: 3.30.200.20 1.10.510.10
2vuw
Structure of human haspin kinase domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Cell: germ cell. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: expression system is phage resistance rosett
Chain: A (329 residues) CATH domains: Unassigned 1.10.510.10
Bound ligand:   Het Group 5ID is 62.00% similar to enzyme product ADP
2vwb
Structure of the archaeal kae1-bud32 fusion protein mj1130: a model for the eukaryotic ekc-keops subcomplex involved in transcription and telomere homeostasis.
Source: Methanocaldococcus jannaschii. Organism_taxid: 243232. Strain: dsm 2661. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (519 residues) CATH domains: Unassigned Unassigned Unassigned 1.10.510.10
2vwi
Structure of the osr1 kinase, a hypertension drug target
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D (237 residues) CATH domains: Unassigned 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2w0j
Crystal structure of chk2 in complex with nsc 109555, a specific inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1c
Structure determination of aurora kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1d
Structure determination of aurora kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (252 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1e
Structure determination of aurora kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: bl21(de3). Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (253 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1f
Structure determination of aurora kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (254 residues) CATH domains: 3.30.200.20 1.10.510.10
2w1g
Structure determination of aurora kinase in complex with inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (255 residues) CATH domains: 3.30.200.20 1.10.510.10
2w4j
X-ray structure of a dap-kinase 2-277
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2w4k
X-ray structure of a dap-kinase 2-302
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2w5a
Human nek2 kinase adp-bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (267 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2w5b
Human nek2 kinase atpgammas-bound
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (271 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AGS is 93.75% similar to enzyme reactant ATP
2w5h
Human nek2 kinase apo
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2w7r
Structure of the pdz domain of human microtubule associated serine-threonine kinase 4
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2
Chains: A, B (95 residues) CATH domain: 2.30.42.10
2w7x
Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel chk2 inhibitor pv1019
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2wb8
Crystal structure of haspin kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (351 residues) CATH domains: Unassigned 1.10.510.10
2wiu
Mercury-modified bacterial persistence regulator hipba
Source: Escherichia coli. Organism_taxid: 562. Strain: dh5alpha. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: invitrogen dh5alpha cells. Other_details: invitrogen dh5alpha
Chains: A, C (431 residues) CATH domain: Unassigned
2wmq
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (246 residues) CATH domains: 3.30.200.20 1.10.510.10
2wmr
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (254 residues) CATH domains: 3.30.200.20 1.10.510.10
2wms
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (243 residues) CATH domains: 3.30.200.20 1.10.510.10
2wmt
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (248 residues) CATH domains: 3.30.200.20 1.10.510.10
2wmu
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (246 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ZYU is 44.83% similar to enzyme product ADP
2wmv
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (251 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ZYV is 46.67% similar to enzyme product ADP
2wmw
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (247 residues) CATH domains: 3.30.200.20 1.10.510.10
2wmx
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (248 residues) CATH domains: 3.30.200.20 1.10.510.10
2wnt
Crystal structure of the human ribosomal protein s6 kinase
Source: Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606
Chains: A, B (281 residues) CATH domains: 3.30.200.20 1.10.510.10
2wp3
Crystal structure of the titin m10-obscurin like 1 ig complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: T (99 residues) CATH domain: 2.60.40.10
2wqe
Structure of s155r aurora-a somatic mutant
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (241 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2wqm
Structure of apo human nek7
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus rpil.
Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10
2wqn
Structure of adp-bound human nek7
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus rpil.
Chain: A (259 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2wqo
Structure of nek2 bound to the aminopyridine cct241950
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus rpil.
Chain: A (242 residues) CATH domains: 3.30.200.20 1.10.510.10
2wtc
Crystal structure of chk2 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
2wtd
Crystal structure of chk2 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2wti
Crystal structure of chk2 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
2wtj
Crystal structure of chk2 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2wtk
Structure of the heterotrimeric lkb1-stradalpha-mo25alpha complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: C, F (285 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2wtv
Aurora-a inhibitor structure
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus rpil.
Chains: A, B, C, D (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2wtw
Aurora-a inhibitor structure (2nd crystal form)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus rpil.
Chain: A (256 residues) CATH domains: 3.30.200.20 1.10.510.10
2wvi
Crystal structure of the n-terminal domain of bubr1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (160 residues)
2wwk
Crystal structure of the titin m10-obscurin like 1 ig f17r mutant complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: T (99 residues) CATH domain: 2.60.40.10
2wwm
Crystal structure of the titin m10-obscurin like 1 ig complex in space group p1
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: D, T (100 residues) CATH domain: 2.60.40.10
2wzj
Catalytic and uba domain of kinase mark2/(par-1) k82r, t208e double mutant
Source: Rattus norvegicus. Rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chains: A, B, C, D, E, F (310 residues) CATH domains: 3.30.200.20 1.10.510.10 1.10.8.10
2x0g
X-ray structure of a dap-kinase calmodulin complex
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.
Chain: A (318 residues) CATH domains: 3.30.200.20 1.10.510.10
2x18
The crystal structure of the ph domain of human akt3 protein kinase
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chains: A, B, C, D, E, F, G, H (111 residues) CATH domain: 2.30.29.30
2x37
Structure of 4-(4-tert-butylbenzyl)-1-(7h-pyrrolo(2,3-d) pyrimidin-4-yl)piperidin-4-amine bound to pkb
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 9606
Chain: A (317 residues) CATH domains: 3.30.200.20 1.10.510.10
2x39
Structure of 4-amino-n-(4-chlorobenzyl)-1-(7h-pyrrolo(2,3-d) pyrimidin-4-yl)piperidine-4-carboxamide bound to pkb
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 9606
Chain: A (317 residues) CATH domains: 3.30.200.20 1.10.510.10
2x4f
The crystal structure of the human myosin light chain kinase loc340156.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chains: A, B (289 residues) CATH domains: 3.30.200.20 1.10.510.10
2x4z
Crystal structure of the human p21-activated kinase 4 in complex with pf-03758309
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10
2x6d
Aurora-a bound to an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (255 residues) CATH domains: 3.30.200.20 1.10.510.10
2x6e
Aurora-a bound to an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (249 residues) CATH domains: 3.30.200.20 1.10.510.10
2x7f
Crystal structure of the kinase domain of human traf2- and nck-interacting kinase with wee1chk1 inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chains: A, B, C, D, E (276 residues) CATH domains: Unassigned 1.10.510.10
2x7g
Structure of human serine-arginine-rich protein-specific kinase 2 (srpk2) bound to purvalanol b
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3-prare2.
Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10
2x81
Structure of aurora a in complex with mln8054
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
Chain: A (242 residues) CATH domains: 3.30.200.20 1.10.510.10
2x8d
Discovery of a novel class of triazolones as checkpoint kinase inhibitors - hit to lead exploration
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group X8D is 40.00% similar to enzyme product ADP
2x8e
Discovery of a novel class of triazolones as checkpoint kinase inhibitors - hit to lead exploration
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (259 residues) CATH domains: 3.30.200.20 1.10.510.10
2x8i
Discovery of a novel class of triazolones as checkpoint kinase inhibitors - hit to lead exploration
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10
2xbj
Crystal structure of chk2 in complex with an inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
2xch
Crystal structure of pdk1 in complex with a pyrazoloquinazoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10
2xck
Crystal structure of pdk1 in complex with a pyrazoloquinazoline inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.
Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10
2xey
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (252 residues) CATH domains: 3.30.200.20 1.10.510.10
2xez
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (249 residues) CATH domains: 3.30.200.20 1.10.510.10
2xf0
Crystal structure of checkpoint kinase 1 (chk1) in complex with inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9
Chain: A (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2xh5
Structure of 4-(4-tert-butylbenzyl)-1-(7h-pyrrolo(2,3-d) pyrimidin-4-yl)piperidin-4-amine bound to pkb
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Synthetic: yes. Organism_taxid: 9606
Chain: A (317 residues) CATH domains: 3.30.200.20 1.10.510.10
2xik
Structure of human ysk1 (yeast sps1-ste20-related kinase 1)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3.
Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10
2xix
Protein kinase pim-1 in complex with fragment-1 from crystallographic fragment screen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2xiy
Protein kinase pim-1 in complex with fragment-2 from crystallographic fragment screen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2xiz
Protein kinase pim-1 in complex with fragment-3 from crystallographic fragment screen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2xj0
Protein kinase pim-1 in complex with fragment-4 from crystallographic fragment screen
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10
2xj1
Protein kinase pim-1 in complex with small molecule inibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2xj2
Protein kinase pim-1 in complex with small molecule inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk3
Structure of nek2 bound to aminopyrazine compound 35
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (247 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk4
Structure of nek2 bound to aminopyrazine compound 17
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (252 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk6
Structure of nek2 bound to aminopyrazine compound 36
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (243 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk7
Structure of nek2 bound to aminopyrazine compound 23
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (246 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk8
Structure of nek2 bound to aminopyrazine compound 15
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (246 residues) CATH domains: 3.30.200.20 1.10.510.10
2xk9
Structural analysis of checkpoint kinase 2 (chk2) in complex inhibitor pv1533
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: codonplus-ril.
Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10
2xkc
Structure of nek2 bound to aminopyrazine compound 14
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (244 residues) CATH domains: 3.30.200.20 1.10.510.10
2xkd
Structure of nek2 bound to aminopyrazine compound 12
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2xke
Structure of nek2 bound to aminipyrazine compound 5
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (243 residues) CATH domains: 3.30.200.20 1.10.510.10
2xkf
Structure of nek2 bound to aminopyrazine compound 2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (250 residues) CATH domains: 3.30.200.20 1.10.510.10
2xm8
Co-crystal structure of a small molecule inhibitor bound to kinase domain of chk2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (265 residues) CATH domains: 3.30.200.20 1.10.510.10
2xm9
Structure of a small molecule inhibitor with the kinase doma chk2
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10
2xne
Structure of aurora-a bound to an imidazopyrazine inhibitor
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (246 residues) CATH domains: 3.30.200.20 1.10.510.10
2xng
Structure of aurora-a bound to a selective imidazopyrazine i
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (254 residues) CATH domains: 3.30.200.20 1.10.510.10
2xnm
Structure of nek2 bound to cct
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10
2xnn
Structure of nek2 bound to cct242430
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: ril.
Chain: A (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2xno
Structure of nek2 bound to cct243779
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: ril.
Chain: A (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2xnp
Structure of nek2 bound to cct244858
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: ril.
Chain: A (253 residues) CATH domains: 3.30.200.20 1.10.510.10
2xru
Aurora-a t288e complexed with pha-828300
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five.
Chain: A (254 residues) CATH domains: 3.30.200.20 1.10.510.10
2xuu
Crystal structure of a dap-kinase 1 mutant
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2xzs
Death associated protein kinase 1 residues 1-312
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B (301 residues) CATH domains: 3.30.200.20 1.10.510.10
2y0a
Structure of dapk1 construct residues 1-304
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chain: A (300 residues) CATH domains: 3.30.200.20 1.10.510.10
2y4i
Ksr2-mek1 heterodimer
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Oryctolagus cuniculus. Rabbit. Organism_taxid: 9986.
Chain: B (265 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2y4p
Dimeric structure of dapk-1 catalytic domain
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Chains: A, B, C, D (251 residues) CATH domains: 3.30.200.20 1.10.510.10
2y4v
Crystal structure of human calmodulin in complex with a dap kinase-1 mutant (w305y) peptide
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta. Synthetic: yes. Organism_taxid: 9606
Chain: B (16 residues)
2y8l
Structure of the regulatory fragment of mammalian ampk in co with two adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (104 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2y8q
Structure of the regulatory fragment of mammalian ampk in co with one adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (104 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group ADP corresponds to enzyme product ADP
2y94
Structure of an active form of mammalian ampk
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chains: A, C (432 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
2y9q
Crystal structure of human erk2 complexed with a mapk dockin
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss. Synthetic: yes. Organism_taxid: 9606
Chain: B (17 residues)
Bound ligand:   Het Group ANP is 81.25% similar to enzyme product ADP
2y9r
Crystal structure of the m10 domain of titin
Source: Homo sapiens. Human. Organism_taxid: 9606. Tissue: muscle. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chain: T (98 residues) CATH domain: 2.60.40.10
2ya3
Structure of the regulatory fragment of mammalian ampk in co with coumarin adp
Source: Rattus norvegicus. Norway rat. Organism_taxid: 10116. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Expression_system_taxid: 562
Chain: A (102 residues) CATH domain: 3.30.310.80
Bound ligand:   Het Group J7V is 56.52% similar to enzyme product ADP
2ya9
Crystal structure of the autoinhibited form of mouse dapk2
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss rare.
Chains: A, B (299 residues) CATH domains: 3.30.200.20 1.10.510.10
2yaa
Crystal structure of the autoinhibited form of mouse dapk2 i complex with atp
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss rare.
Chains: A, B (300 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group ATP corresponds to enzyme reactant ATP
2yab
Crystal structure of the autoinhibited form of mouse dapk2 i complex with amp
Source: Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: plyss rare.
Chains: A, B (299 residues) CATH domains: 3.30.200.20 1.10.510.10
Bound ligand:   Het Group AMP is 85.19% similar to enzyme product ADP
2yak
Structure of death-associated protein kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (osv)
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.
Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10
2ycf
Crystal structure of checkpoint kinase 2 in complex with inhibitor pv1531
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10
2ycq
Crystal structure of checkpoint kinase 2 in complex with inh pv1115
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10
2ycr
Crystal structure of checkpoint kinase 2 in complex with inh pv976
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10
2ycs
Crystal structure of checkpoint kinase 2 in complex with pv7
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: ril.
Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10
2ydi
Discovery of checkpoint kinase inhibitor azd7762 by structur design and optimization of thiophene carboxamide ureas
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9
Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10
2ydj
Discovery of checkpoint kinase inhibitor azd7762 by structur design and optimization of thiophene carboxamide ureas
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9
Chains: A, B (254 residues) CATH domains: 3.30.200.20 1.10.510.10
2ydk
Discovery of checkpoint kinase inhibitor azd7762 by structur design and optimization of thiophene carboxamide ureas
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf-9
Chain: A (263 residues) CATH domains: 3.30.200.20 1.10.510.10
2yer
Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spod