PDBsum entry 3tk6

Hydrolase/hydrolase inhibitor

PDB id: 3tk6

Contents

Protein chains

233 a.a.

54 a.a.

Ligands

D46

Metals

_CA ×2

Waters ×223

PDB id:

3tk6

Name:

Hydrolase/hydrolase inhibitor

Title:

Factor xa in complex with d46-5241

Structure:

Factor x heavy chain. Chain: a. Fragment: unp residues 235-467. Synonym: coagulation factor x heavy chain, activated factor xa heavy chain. Factor x light chain. Chain: b. Fragment: unp residues 125-178. Synonym: coagulation factor x light chain.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Resolution:

1.80Å R-factor: 0.205 R-free: 0.241

Authors:

M.Suzuki,A.Mochizuki,T.Nagata,H.Takano,H.Kanno,M.Kishida,T.Ohta

Key ref:

A.Mochizuki et al. Zwitter ionic potent durable orally active factor xa inhibitor.. To be published, .

Date:

25-Aug-11 Release date: 29-Aug-12

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 233 a.a.

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 54 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.6 - coagulation factor Xa.
• Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.