PDBsum entry 3rug

Immune system

PDB id: 3rug

Contents

Protein chains

286 a.a.

98 a.a.

198 a.a.

236 a.a.

Ligands

NAG-NAG ×2

DB6 ×2

NAG ×4

Waters ×355

PDB id:

3rug

Name:

Immune system

Title:

Crystal structure of valpha10-vbeta8.1 nkt tcr in complex with cd1d- alphaglucosylceramide (c20:2)

Structure:

Antigen-presenting glycoprotein cd1d1. Chain: a, c. Fragment: extracellular domain. Engineered: yes. Beta-2-microglobulin. Chain: b, d. Engineered: yes. Valpha10(mouse variable domain, human constant domain). Chain: e, g.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: cd1d1, cd1.1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: b2m. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.20Å R-factor: 0.212 R-free: 0.254

Authors:

O.Patel,J.Rossjohn

Key ref:

A.P.Uldrich et al. (2011). A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nat Immunol, 12, 616-623. PubMed id: 21666690

Date:

05-May-11 Release date: 03-Aug-11

Protein chains

P11609  (CD1D1_MOUSE) -  Antigen-presenting glycoprotein CD1d1 from Mus musculus

Seq: 336 a.a.

Struc: 286 a.a.*

Protein chains

P01887  (B2MG_MOUSE) -  Beta-2-microglobulin from Mus musculus

Seq: 119 a.a.

Struc: 98 a.a.

Protein chains

No UniProt id for this chain

Struc: 198 a.a.

Protein chains

No UniProt id for this chain

Struc: 236 a.a.

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Nat Immunol 12:616-623 (2011)

PubMed id: 21666690

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties.

A.P.Uldrich, O.Patel, G.Cameron, D.G.Pellicci, E.B.Day, L.C.Sullivan, K.Kyparissoudis, L.Kjer-Nielsen, J.P.Vivian, B.Cao, A.G.Brooks, S.J.Williams, P.Illarionov, G.S.Besra, S.J.Turner, S.A.Porcelli, J.McCluskey, M.J.Smyth, J.Rossjohn, D.I.Godfrey.

ABSTRACT

No abstract given.