PDBsum entry 3qkt

Replication

PDB id

3qkt

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Contents

			Protein chains

					339 a.a.


					319 a.a.

			Ligands

					ANP ×4

			Metals

					_MG ×4

			Waters ×935

PDB id:

3qkt

Links

Name:

Replication

Title:

Rad50 abc-atpase with adjacent coiled-coil region in complex with amp- pnp

Structure:

DNA double-strand break repair rad50 atpase. Chain: a, b, c, d. Fragment: unp residues 1-177, 726-882. Synonym: rad50 abc-atpase. Engineered: yes

Source:

Pyrococcus furiosus. Organism_taxid: 2261. Gene: rad50, pf1167. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å

R-factor:

0.195

R-free:

0.244

Authors:

G.J.Williams,R.S.Williams,A.Arvai,G.Moncalian,J.A.Tainer

Key ref:

G.J.Williams et al. (2011). ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair. Nat Struct Biol, 18, 423-431. PubMed id: 21441914

Date:

01-Feb-11

Release date:

30-Mar-11

PROCHECK

	Headers

	References

Protein chains

P58301 (RAD50_PYRFU) - DNA double-strand break repair Rad50 ATPase from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Seq: Struc:

Seq: Struc:					882 a.a. 339 a.a.*

Protein chains

P58301 (RAD50_PYRFU) - DNA double-strand break repair Rad50 ATPase from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)

Seq: Struc:

Seq: Struc:					882 a.a. 319 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 268 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chains A, B, C, D: E.C.3.6.-.-

[IntEnz] [ExPASy] [KEGG] [BRENDA]

	Nat Struct Biol 18:423-431 (2011)
PubMed id: 21441914

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
G.J.Williams, R.S.Williams, J.S.Williams, G.Moncalian, A.S.Arvai, O.Limbo, G.Guenther, S.SilDas, M.Hammel, P.Russell, J.A.Tainer.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22705791

C.B.Schiller, K.Lammens, I.Guerini, B.Coordes, H.Feldmann, F.Schlauderer, C.Möckel, A.Schele, K.Strässer, S.P.Jackson, and K.P.Hopfner (2012).
Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.

Nat Struct Mol Biol, 19, 693-700.

PDB codes:

4fbk 4fbq 4fbw 4fcx

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.