PDBsum entry 2m5l

Viral protein

PDB id: 2m5l

Contents

Protein chain

20 a.a.

PDB id:

2m5l

Name:

Viral protein

Title:

Ns5a308

Structure:

Ns5a protein. Chain: a. Fragment: unp residues 2280-2301. Engineered: yes

Source:

Hepatitis c virus. Organism_taxid: 333284. Strain: con 1. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: 15n 13c labeled sample

NMR struc:

28 models

Authors:

R.Montserret,A.Badillo,X.Hanoulle,G.Lippens,F.Penin

Key ref:

R.Montserret et al. Ns5a308. To be published, .

Date:

27-Feb-13 Release date: 05-Mar-14

Protein chain

Q9WIK7  (Q9WIK7_9HEPC) -  Genome polyprotein from Hepacivirus hominis

Seq: 3012 a.a.

Struc: 20 a.a.

Enzyme reactions

• Enzyme class 1: E.C.3.4.21.98 - hepacivirin.
• Reaction: Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
• Enzyme class 2: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺
• Enzyme class 3: E.C.3.6.4.13 - Rna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site