PDBsum entry 2ei8

Hydrolase

PDB id: 2ei8

Contents

Protein chains

233 a.a. *

54 a.a. *

Ligands

DT8

Metals

_CA ×2

Waters ×166

* Residue conservation analysis

PDB id:

2ei8

Name:

Hydrolase

Title:

Factor xa in complex with the inhibitor (1s,2r,4s)-n1-[(5-chloroindol- 2-yl)carbonyl]-4-(n,n-dimethylcarbamoyl)-n2-[(5-methyl-4,5,6,7- tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2- cyclohexanediamine

Structure:

Coagulation factor x, heavy chain. Chain: a. Fragment: residues 16-243. Synonym: stuart factor, stuart-prower factor. Coagulation factor x, light chain. Chain: b. Fragment: residues 85-138. Synonym: stuart factor, stuart-prower factor. Ec: 3.4.21.6

Source:

Homo sapiens. Human. Organism_taxid: 9606. Other_details: proteolytic cleavage product

Resolution:

2.10Å R-factor: 0.208 R-free: 0.250

Authors:

M.Suzuki

Key ref:

T.Nagata et al. Discovery of n-{(1r,2s,5s)-2-{[(5-Chloroindol-2-Yl) carbonyl]amino}-5-[(Dimethylamino) carbonyl]cyclohexyl}-5-Methyl-4,5,6,7- Tetrahydrothiazolo[5,4-C]pyridine-2-Carboxamide hydrochloride: a novel, Potent and orally active direct inhibitor of factor xa. To be published, .

Date:

12-Mar-07 Release date: 18-Mar-08

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 233 a.a.

Protein chain

P00742  (FA10_HUMAN) -  Coagulation factor X from Homo sapiens

Seq: 488 a.a.

Struc: 54 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.4.21.6 - coagulation factor Xa.
• Reaction: Preferential cleavage: Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.