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Contents |
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276 a.a.
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99 a.a.
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13 a.a.
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204 a.a.
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241 a.a.
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* Residue conservation analysis
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PDB id:
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Immune system
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Title:
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Crystal structure of sb27 tcr in complex with hla-b 3508-13Mer peptide
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Structure:
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Hla-b35 variant. Chain: a, f, k, q. Fragment: extracellular domains, alpha1,2,3. Engineered: yes. Beta-2-microglobulin. Chain: b, g, l, r. Engineered: yes. Ebv peptide lpeplpqgqltay. Chain: c, h, m, s.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Other_details: synthetic peptide lpeplpqgqltay.
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Biol. unit:
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Pentamer (from
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Resolution:
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2.50Å
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R-factor:
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0.247
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R-free:
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0.278
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Authors:
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F.E.Tynan,S.R.Burrows,A.M.Buckle,C.S.Clements,N.A.Borg,J.J.Miles, T.Beddoe,J.C.Whisstock,M.C.Wilce,S.L.Silins,J.M.Burrows,L.Kjer- Nielsen,L.Konstenko,A.W.Purcell,J.Mccluskey,J.Rossjohn
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Key ref:
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F.E.Tynan
et al.
(2005).
T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
Nat Immunol,
6,
1114-1122.
PubMed id:
DOI:
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Date:
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03-Aug-05
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Release date:
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11-Oct-05
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PROCHECK
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Headers
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References
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P01889
(1B07_HUMAN) -
HLA class I histocompatibility antigen, B alpha chain from Homo sapiens
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Seq:
Struc:
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362 a.a.
276 a.a.*
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P61769
(B2MG_HUMAN) -
Beta-2-microglobulin from Homo sapiens
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Seq:
Struc:
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119 a.a.
99 a.a.
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P03206
(BZLF1_EBVB9) -
Lytic switch protein BZLF1 from Epstein-Barr virus (strain B95-8)
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Seq:
Struc:
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245 a.a.
13 a.a.
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DOI no:
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Nat Immunol
6:1114-1122
(2005)
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PubMed id:
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide.
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F.E.Tynan,
S.R.Burrows,
A.M.Buckle,
C.S.Clements,
N.A.Borg,
J.J.Miles,
T.Beddoe,
J.C.Whisstock,
M.C.Wilce,
S.L.Silins,
J.M.Burrows,
L.Kjer-Nielsen,
L.Kostenko,
A.W.Purcell,
J.McCluskey,
J.Rossjohn.
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ABSTRACT
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Unusually long major histocompatibility complex (MHC) class I-restricted
epitopes are important in immunity, but their 'bulged' conformation represents a
potential obstacle to alphabeta T cell receptor (TCR)-MHC class I docking. To
elucidate how such recognition is achieved while still preserving MHC
restriction, we have determined here the structure of a TCR in complex with
HLA-B(*)3508 presenting a peptide 13 amino acids in length. This complex was
atypical of TCR-peptide-MHC class I interactions, being dominated at the
interface by peptide-mediated interactions. The TCR assumed two distinct
orientations, swiveling on top of the centrally bulged, rigid peptide such that
only limited contacts were made with MHC class I. Although the TCR-peptide
recognition resembled an antibody-antigen interaction, the TCR-MHC class I
contacts defined a minimal 'generic footprint' of MHC-restriction. Thus our
findings simultaneously demonstrate the considerable adaptability of the TCR and
the 'shape' of MHC restriction.
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Selected figure(s)
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Figure 2.
Figure 2. SB27 TCR contacts at the interface. (a) 'Footprint'
of the SB27 TCR on the HLA-B^*3508-LPEP complex. There are
limited MHC-mediated contacts with the SB27 TCR on the gray
surface representation of the HLA-B^*3508 heavy chain. (b)
'Footprint' of the LC13 TCR in complex with HLA-B8-FLRGRAYGL,
showing the focus toward the carboxy-terminal end of the
peptide^5. (c) Closer view of the SB27 TCR contacts with the
HLA-B^*3508-LPEP complex. HLA-B^*3508  -helices,
light gray; peptide, orange; conformation of Gln155 as it
appears in the binary complex (HLA-B^*3508-LPEP)3, dark gray;
side chains from the triad of residues mediating
MHC-restriction, gold. CDR loop colors are as in Figure 1b.
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Figure 4.
Figure 4. SB27 TCR recognition of the HLA-B^*3508-LPEP complex
is antibody like and is dominated by TCR-peptide interactions.
(a,b) GRASP image of the SB27 TCR-peptide interaction (a)
compared with that of a complex between an Fab and a peptide
from human rhinovirus viral capsid protein VP2 (b; Protein Data
Bank accession number, 1A3R)46. TCR V[  ]and
Fab V[H], red; TCR V  and
Fab V[L], blue; Epstein-Barr virus LPEP and rhinovirus VP2
peptides, yellow. (c) Closer view of the SB27 TCR interactions
with the solvent-exposed side chains of the LPEP peptide.
Peptide, orange; CDR loop colors are as in Figure 1b. (d)
Dose-response assays of analogs of the 13-residue peptide
(LPEPLPQGQLTAY) that include single-amino acid substitutions,
assessing recognition by SB27 CTLs (chromium-release assays,
left) and binding to 'empty' HLA-B^*3508 with the transporter
associated with antigen processing-deficient T2-B^*3508 (right).
Peptides recognized well in the cytotoxicity assays are assumed
to bind well to HLA-B^*3508 and are therefore excluded from the
MHC-binding assays (NT). Data represent peptide concentrations
for half-maximal lysis or binding calculated from dose-response
curves for each peptide and are representative of two
independent experiments with similar results.
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The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nat Immunol
(2005,
6,
1114-1122)
copyright 2005.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
|
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Reference
|
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|
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D.K.Sethi,
D.A.Schubert,
A.K.Anders,
A.Heroux,
D.A.Bonsor,
C.P.Thomas,
E.J.Sundberg,
J.Pyrdol,
and
K.W.Wucherpfennig
(2011).
A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC.
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J Exp Med,
208,
91.
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PDB code:
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J.J.Miles,
D.C.Douek,
and
D.A.Price
(2011).
Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.
|
| |
Immunol Cell Biol,
89,
375-387.
|
|
|
|
|
|
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J.M.Khan,
and
S.Ranganathan
(2011).
Understanding TR Binding to pMHC Complexes: How Does a TR Scan Many pMHC Complexes yet Preferentially Bind to One.
|
| |
PLoS One,
6,
e17194.
|
|
|
|
|
|
|
P.A.van der Merwe,
and
O.Dushek
(2011).
Mechanisms for T cell receptor triggering.
|
| |
Nat Rev Immunol,
11,
47-55.
|
|
|
|
|
|
|
S.Gras,
L.Kjer-Nielsen,
Z.Chen,
J.Rossjohn,
and
J.McCluskey
(2011).
The structural bases of direct T-cell allorecognition: implications for T-cell-mediated transplant rejection.
|
| |
Immunol Cell Biol,
89,
388-395.
|
|
|
|
|
|
|
A.Theodossis,
C.Guillonneau,
A.Welland,
L.K.Ely,
C.S.Clements,
N.A.Williamson,
A.I.Webb,
J.A.Wilce,
R.J.Mulder,
M.A.Dunstone,
P.C.Doherty,
J.McCluskey,
A.W.Purcell,
S.J.Turner,
and
J.Rossjohn
(2010).
Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition.
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| |
Proc Natl Acad Sci U S A,
107,
5534-5539.
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PDB codes:
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C.T.Spencer,
P.Gilchuk,
S.M.Dragovic,
and
S.Joyce
(2010).
Minor histocompatibility antigens: presentation principles, recognition logic and the potential for a healing hand.
|
| |
Curr Opin Organ Transplant,
15,
512-525.
|
|
|
|
|
|
|
D.K.Cole,
E.S.Edwards,
K.K.Wynn,
M.Clement,
J.J.Miles,
K.Ladell,
J.Ekeruche,
E.Gostick,
K.J.Adams,
A.Skowera,
M.Peakman,
L.Wooldridge,
D.A.Price,
and
A.K.Sewell
(2010).
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition.
|
| |
J Immunol,
185,
2600-2610.
|
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|
|
|
|
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D.R.Flower,
I.K.Macdonald,
K.Ramakrishnan,
M.N.Davies,
and
I.A.Doytchinova
(2010).
Computer aided selection of candidate vaccine antigens.
|
| |
Immunome Res,
6,
S1.
|
|
|
|
|
|
|
J.J.Miles,
A.M.Bulek,
D.K.Cole,
E.Gostick,
A.J.Schauenburg,
G.Dolton,
V.Venturi,
M.P.Davenport,
M.P.Tan,
S.R.Burrows,
L.Wooldridge,
D.A.Price,
P.J.Rizkallah,
and
A.K.Sewell
(2010).
Genetic and structural basis for selection of a ubiquitous T cell receptor deployed in Epstein-Barr virus infection.
|
| |
PLoS Pathog,
6,
e1001198.
|
|
|
PDB code:
|
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|
|
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|
|
J.Liu,
P.Wu,
F.Gao,
J.Qi,
A.Kawana-Tachikawa,
J.Xie,
C.J.Vavricka,
A.Iwamoto,
T.Li,
and
G.F.Gao
(2010).
Novel immunodominant peptide presentation strategy: a featured HLA-A*2402-restricted cytotoxic T-lymphocyte epitope stabilized by intrachain hydrogen bonds from severe acute respiratory syndrome coronavirus nucleocapsid protein.
|
| |
J Virol,
84,
11849-11857.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
L.Wooldridge,
M.Clement,
A.Lissina,
E.S.Edwards,
K.Ladell,
J.Ekeruche,
R.E.Hewitt,
B.Laugel,
E.Gostick,
D.K.Cole,
R.Debets,
C.Berrevoets,
J.J.Miles,
S.R.Burrows,
D.A.Price,
and
A.K.Sewell
(2010).
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
|
| |
J Immunol,
184,
3357-3366.
|
|
|
|
|
|
|
M.J.Ciesielski,
M.S.Ahluwalia,
S.A.Munich,
M.Orton,
T.Barone,
A.Chanan-Khan,
and
R.A.Fenstermaker
(2010).
Antitumor cytotoxic T-cell response induced by a survivin peptide mimic.
|
| |
Cancer Immunol Immunother,
59,
1211-1221.
|
|
|
|
|
|
|
N.Blanchard,
T.Kanaseki,
H.Escobar,
F.Delebecque,
N.A.Nagarajan,
E.Reyes-Vargas,
D.K.Crockett,
D.H.Raulet,
J.C.Delgado,
and
N.Shastri
(2010).
Endoplasmic reticulum aminopeptidase associated with antigen processing defines the composition and structure of MHC class I peptide repertoire in normal and virus-infected cells.
|
| |
J Immunol,
184,
3033-3042.
|
|
|
|
|
|
|
N.E.Elamin,
C.Bade-Doeding,
R.Blasczyk,
and
B.Eiz-Vesper
(2010).
Polymorphism between HLA-A*0301 and A*0302 located outside the pocket F alters the PΩ peptide motif.
|
| |
Tissue Antigens,
76,
487-490.
|
|
|
|
|
|
|
S.A.Valkenburg,
S.Gras,
C.Guillonneau,
N.L.La Gruta,
P.G.Thomas,
A.W.Purcell,
J.Rossjohn,
P.C.Doherty,
S.J.Turner,
and
K.Kedzierska
(2010).
Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold.
|
| |
PLoS Pathog,
6,
0.
|
|
|
PDB code:
|
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|
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|
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S.Gras,
Z.Chen,
J.J.Miles,
Y.C.Liu,
M.J.Bell,
L.C.Sullivan,
L.Kjer-Nielsen,
R.M.Brennan,
J.M.Burrows,
M.A.Neller,
R.Khanna,
A.W.Purcell,
A.G.Brooks,
J.McCluskey,
J.Rossjohn,
and
S.R.Burrows
(2010).
Allelic polymorphism in the T cell receptor and its impact on immune responses.
|
| |
J Exp Med,
207,
1555-1567.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.R.Burrows,
Z.Chen,
J.K.Archbold,
F.E.Tynan,
T.Beddoe,
L.Kjer-Nielsen,
J.J.Miles,
R.Khanna,
D.J.Moss,
Y.C.Liu,
S.Gras,
L.Kostenko,
R.M.Brennan,
C.S.Clements,
A.G.Brooks,
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2010).
Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.
|
| |
Proc Natl Acad Sci U S A,
107,
10608-10613.
|
|
|
PDB codes:
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Y.Fujii,
T.Matsutani,
K.Kitaura,
S.Suzuki,
T.Itoh,
T.Takasaki,
R.Suzuki,
and
I.Kurane
(2010).
Comprehensive analysis and characterization of the TCR alpha chain sequences in the common marmoset.
|
| |
Immunogenetics,
62,
383-395.
|
|
|
|
|
|
|
D.K.Cole,
F.Yuan,
P.J.Rizkallah,
J.J.Miles,
E.Gostick,
D.A.Price,
G.F.Gao,
B.K.Jakobsen,
and
A.K.Sewell
(2009).
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
|
| |
J Biol Chem,
284,
27281-27289.
|
|
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PDB code:
|
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|
|
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|
|
|
G.Stewart-Jones,
A.Wadle,
A.Hombach,
E.Shenderov,
G.Held,
E.Fischer,
S.Kleber,
F.Stenner-Liewen,
S.Bauer,
A.McMichael,
A.Knuth,
H.Abken,
A.A.Hombach,
V.Cerundolo,
E.Y.Jones,
and
C.Renner
(2009).
Rational development of high-affinity T-cell receptor-like antibodies.
|
| |
Proc Natl Acad Sci U S A,
106,
5784-5788.
|
|
|
PDB codes:
|
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|
|
|
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|
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J.K.Archbold,
W.A.Macdonald,
S.Gras,
L.K.Ely,
J.J.Miles,
M.J.Bell,
R.M.Brennan,
T.Beddoe,
M.C.Wilce,
C.S.Clements,
A.W.Purcell,
J.McCluskey,
S.R.Burrows,
and
J.Rossjohn
(2009).
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition.
|
| |
J Exp Med,
206,
209-219.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.Petersen,
S.J.Wurzbacher,
N.A.Williamson,
S.H.Ramarathinam,
H.H.Reid,
A.K.Nair,
A.Y.Zhao,
R.Nastovska,
G.Rudge,
J.Rossjohn,
and
A.W.Purcell
(2009).
Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.
|
| |
Proc Natl Acad Sci U S A,
106,
2776-2781.
|
|
|
PDB codes:
|
|
|
|
|
|
|
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K.C.Garcia,
J.J.Adams,
D.Feng,
and
L.K.Ely
(2009).
The molecular basis of TCR germline bias for MHC is surprisingly simple.
|
| |
Nat Immunol,
10,
143-147.
|
|
|
|
|
|
|
K.Rubtsova,
J.P.Scott-Browne,
F.Crawford,
S.Dai,
P.Marrack,
and
J.W.Kappler
(2009).
Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions.
|
| |
Proc Natl Acad Sci U S A,
106,
7951-7956.
|
|
|
|
|
|
|
P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
A.Ziegler,
and
B.Uchanska-Ziegler
(2009).
Conformational changes within the HLA-A1:MAGE-A1 complex induced by binding of a recombinant antibody fragment with TCR-like specificity.
|
| |
Protein Sci,
18,
37-49.
|
|
|
PDB code:
|
|
|
|
|
|
|
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P.Kumar,
A.Vahedi-Faridi,
W.Saenger,
E.Merino,
J.A.López de Castro,
B.Uchanska-Ziegler,
and
A.Ziegler
(2009).
Structural basis for T cell alloreactivity among three HLA-B14 and HLA-B27 antigens.
|
| |
J Biol Chem,
284,
29784-29797.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
T.Beddoe,
Z.Chen,
C.S.Clements,
L.K.Ely,
S.R.Bushell,
J.P.Vivian,
L.Kjer-Nielsen,
S.S.Pang,
M.A.Dunstone,
Y.C.Liu,
W.A.Macdonald,
M.A.Perugini,
M.C.Wilce,
S.R.Burrows,
A.W.Purcell,
T.Tiganis,
S.P.Bottomley,
J.McCluskey,
and
J.Rossjohn
(2009).
Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor.
|
| |
Immunity,
30,
777-788.
|
|
|
|
|
|
|
W.A.Macdonald,
Z.Chen,
S.Gras,
J.K.Archbold,
F.E.Tynan,
C.S.Clements,
M.Bharadwaj,
L.Kjer-Nielsen,
P.M.Saunders,
M.C.Wilce,
F.Crawford,
B.Stadinsky,
D.Jackson,
A.G.Brooks,
A.W.Purcell,
J.W.Kappler,
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2009).
T cell allorecognition via molecular mimicry.
|
| |
Immunity,
31,
897-908.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
Y.Chen,
Y.Shi,
H.Cheng,
Y.Q.An,
and
G.F.Gao
(2009).
Structural immunology and crystallography help immunologists see the immune system in action: how T and NK cells touch their ligands.
|
| |
IUBMB Life,
61,
579-590.
|
|
|
|
|
|
|
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2008).
The fidelity, occasional promiscuity, and versatility of T cell receptor recognition.
|
| |
Immunity,
28,
304-314.
|
|
|
|
|
|
|
E.J.Collins,
and
D.S.Riddle
(2008).
TCR-MHC docking orientation: natural selection, or thymic selection?
|
| |
Immunol Res,
41,
267-294.
|
|
|
|
|
|
|
E.J.Petrie,
C.S.Clements,
J.Lin,
L.C.Sullivan,
D.Johnson,
T.Huyton,
A.Heroux,
H.L.Hoare,
T.Beddoe,
H.H.Reid,
M.C.Wilce,
A.G.Brooks,
and
J.Rossjohn
(2008).
CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence.
|
| |
J Exp Med,
205,
725-735.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
H.Watarai,
R.Nakagawa,
M.Omori-Miyake,
N.Dashtsoodol,
and
M.Taniguchi
(2008).
Methods for detection, isolation and culture of mouse and human invariant NKT cells.
|
| |
Nat Protoc,
3,
70-78.
|
|
|
|
|
|
|
J.Ishizuka,
G.B.Stewart-Jones,
A.van der Merwe,
J.I.Bell,
A.J.McMichael,
and
E.Y.Jones
(2008).
The structural dynamics and energetics of an immunodominant T cell receptor are programmed by its Vbeta domain.
|
| |
Immunity,
28,
171-182.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
J.K.Archbold,
W.A.Macdonald,
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2008).
T-cell allorecognition: a case of mistaken identity or déjà vu?
|
| |
Trends Immunol,
29,
220-226.
|
|
|
|
|
|
|
K.K.Wynn,
Z.Fulton,
L.Cooper,
S.L.Silins,
S.Gras,
J.K.Archbold,
F.E.Tynan,
J.J.Miles,
J.McCluskey,
S.R.Burrows,
J.Rossjohn,
and
R.Khanna
(2008).
Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection.
|
| |
Blood,
111,
4283-4292.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
K.Kedzierska,
C.Guillonneau,
S.Gras,
L.A.Hatton,
R.Webby,
A.W.Purcell,
J.Rossjohn,
P.C.Doherty,
and
S.J.Turner
(2008).
Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy.
|
| |
Proc Natl Acad Sci U S A,
105,
19408-19413.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Kedzierska,
N.L.La Gruta,
J.Stambas,
S.J.Turner,
and
P.C.Doherty
(2008).
Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity.
|
| |
Mol Immunol,
45,
607-618.
|
|
|
|
|
|
|
L.K.Ely,
S.R.Burrows,
A.W.Purcell,
J.Rossjohn,
and
J.McCluskey
(2008).
T-cells behaving badly: structural insights into alloreactivity and autoimmunity.
|
| |
Curr Opin Immunol,
20,
575-580.
|
|
|
|
|
|
|
M.Chiriva-Internati,
R.Ferraro,
M.Prabhakar,
Y.Yu,
L.Baggoni,
J.Moreno,
N.Gagliano,
N.Portinaro,
M.R.Jenkins,
E.E.Frezza,
F.Hardwicke,
N.D'Cunha,
W.Kast,
and
E.Cobos
(2008).
The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myeloma.
|
| |
J Transl Med,
6,
15.
|
|
|
|
|
|
|
N.Blanchard,
and
N.Shastri
(2008).
Coping with loss of perfection in the MHC class I peptide repertoire.
|
| |
Curr Opin Immunol,
20,
82-88.
|
|
|
|
|
|
|
P.Marrack,
J.P.Scott-Browne,
S.Dai,
L.Gapin,
and
J.W.Kappler
(2008).
Evolutionarily conserved amino acids that control TCR-MHC interaction.
|
| |
Annu Rev Immunol,
26,
171-203.
|
|
|
|
|
|
|
S.Gras,
L.Kjer-Nielsen,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2008).
T-cell receptor bias and immunity.
|
| |
Curr Opin Immunol,
20,
119-125.
|
|
|
|
|
|
|
T.Mareeva,
E.Martinez-Hackert,
and
Y.Sykulev
(2008).
How a T cell receptor-like antibody recognizes major histocompatibility complex-bound peptide.
|
| |
J Biol Chem,
283,
29053-29059.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
V.Venturi,
D.A.Price,
D.C.Douek,
and
M.P.Davenport
(2008).
The molecular basis for public T-cell responses?
|
| |
Nat Rev Immunol,
8,
231-238.
|
|
|
|
|
|
|
A.W.Purcell,
J.McCluskey,
and
J.Rossjohn
(2007).
More than one reason to rethink the use of peptides in vaccine design.
|
| |
Nat Rev Drug Discov,
6,
404-414.
|
|
|
|
|
|
|
C.Mazza,
and
B.Malissen
(2007).
What guides MHC-restricted TCR recognition?
|
| |
Semin Immunol,
19,
225-235.
|
|
|
|
|
|
|
C.Mazza,
N.Auphan-Anezin,
C.Gregoire,
A.Guimezanes,
C.Kellenberger,
A.Roussel,
A.Kearney,
P.A.van der Merwe,
A.M.Schmitt-Verhulst,
and
B.Malissen
(2007).
How much can a T-cell antigen receptor adapt to structurally distinct antigenic peptides?
|
| |
EMBO J,
26,
1972-1983.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
D.Feng,
C.J.Bond,
L.K.Ely,
J.Maynard,
and
K.C.Garcia
(2007).
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'.
|
| |
Nat Immunol,
8,
975-983.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
E.Gostick,
D.K.Cole,
S.L.Hutchinson,
L.Wooldridge,
S.Tafuro,
B.Laugel,
A.Lissina,
A.Oxenius,
J.M.Boulter,
D.A.Price,
and
A.K.Sewell
(2007).
Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor.
|
| |
Eur J Immunol,
37,
479-486.
|
|
|
|
|
|
|
F.E.Tynan,
H.H.Reid,
L.Kjer-Nielsen,
J.J.Miles,
M.C.Wilce,
L.Kostenko,
N.A.Borg,
N.A.Williamson,
T.Beddoe,
A.W.Purcell,
S.R.Burrows,
J.McCluskey,
and
J.Rossjohn
(2007).
A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule.
|
| |
Nat Immunol,
8,
268-276.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
G.E.Hammer,
F.Gonzalez,
E.James,
H.Nolla,
and
N.Shastri
(2007).
In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides.
|
| |
Nat Immunol,
8,
101-108.
|
|
|
|
|
|
|
J.H.Kessler,
and
C.J.Melief
(2007).
Identification of T-cell epitopes for cancer immunotherapy.
|
| |
Leukemia,
21,
1859-1874.
|
|
|
|
|
|
|
J.Rossjohn,
and
J.McCluskey
(2007).
How a home-grown T cell receptor interacts with a foreign landscape.
|
| |
Cell,
129,
19-20.
|
|
|
|
|
|
|
L.A.Colf,
A.J.Bankovich,
N.A.Hanick,
N.A.Bowerman,
L.L.Jones,
D.M.Kranz,
and
K.C.Garcia
(2007).
How a single T cell receptor recognizes both self and foreign MHC.
|
| |
Cell,
129,
135-146.
|
|
|
PDB codes:
|
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|
|
L.Deng,
and
R.A.Mariuzza
(2007).
Recognition of self-peptide-MHC complexes by autoimmune T-cell receptors.
|
| |
Trends Biochem Sci,
32,
500-508.
|
|
|
|
|
|
|
L.Deng,
R.J.Langley,
P.H.Brown,
G.Xu,
L.Teng,
Q.Wang,
M.I.Gonzales,
G.G.Callender,
M.I.Nishimura,
S.L.Topalian,
and
R.A.Mariuzza
(2007).
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor.
|
| |
Nat Immunol,
8,
398-408.
|
|
|
PDB codes:
|
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|
|
|
|
|
M.Koch,
S.Camp,
T.Collen,
D.Avila,
J.Salomonsen,
H.J.Wallny,
A.van Hateren,
L.Hunt,
J.P.Jacob,
F.Johnston,
D.A.Marston,
I.Shaw,
P.R.Dunbar,
V.Cerundolo,
E.Y.Jones,
and
J.Kaufman
(2007).
Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.
|
| |
Immunity,
27,
885-899.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
N.A.Borg,
K.S.Wun,
L.Kjer-Nielsen,
M.C.Wilce,
D.G.Pellicci,
R.Koh,
G.S.Besra,
M.Bharadwaj,
D.I.Godfrey,
J.McCluskey,
and
J.Rossjohn
(2007).
CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor.
|
| |
Nature,
448,
44-49.
|
|
|
PDB code:
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|
|
|
|
|
N.J.Felix,
and
P.M.Allen
(2007).
Specificity of T-cell alloreactivity.
|
| |
Nat Rev Immunol,
7,
942-953.
|
|
|
|
|
|
|
P.J.Miller,
Y.Pazy,
B.Conti,
D.Riddle,
E.Appella,
and
E.J.Collins
(2007).
Single MHC mutation eliminates enthalpy associated with T cell receptor binding.
|
| |
J Mol Biol,
373,
315-327.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
R.M.Brennan,
J.J.Miles,
S.L.Silins,
M.J.Bell,
J.M.Burrows,
and
S.R.Burrows
(2007).
Predictable alphabeta T-cell receptor selection toward an HLA-B*3501-restricted human cytomegalovirus epitope.
|
| |
J Virol,
81,
7269-7273.
|
|
|
|
|
|
|
X.G.Yu,
M.Lichterfeld,
S.Chetty,
K.L.Williams,
S.K.Mui,
T.Miura,
N.Frahm,
M.E.Feeney,
Y.Tang,
F.Pereyra,
M.X.Labute,
K.Pfafferott,
A.Leslie,
H.Crawford,
R.Allgaier,
W.Hildebrand,
R.Kaslow,
C.Brander,
T.M.Allen,
E.S.Rosenberg,
P.Kiepiela,
M.Vajpayee,
P.A.Goepfert,
M.Altfeld,
P.J.Goulder,
and
B.D.Walker
(2007).
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
|
| |
J Virol,
81,
1619-1631.
|
|
|
|
|
|
|
Y.Mimura,
Y.Mimura-Kimura,
K.Doores,
D.Golgher,
B.G.Davis,
R.A.Dwek,
P.M.Rudd,
and
T.Elliott
(2007).
Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.
|
| |
Proc Natl Acad Sci U S A,
104,
5983-5988.
|
|
|
|
|
|
|
C.S.Clements,
M.A.Dunstone,
W.A.Macdonald,
J.McCluskey,
and
J.Rossjohn
(2006).
Specificity on a knife-edge: the alphabeta T cell receptor.
|
| |
Curr Opin Struct Biol,
16,
787-795.
|
|
|
|
|
|
|
H.L.Hoare,
L.C.Sullivan,
G.Pietra,
C.S.Clements,
E.J.Lee,
L.K.Ely,
T.Beddoe,
M.Falco,
L.Kjer-Nielsen,
H.H.Reid,
J.McCluskey,
L.Moretta,
J.Rossjohn,
and
A.G.Brooks
(2006).
Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
|
| |
Nat Immunol,
7,
256-264.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
J.K.Archbold,
W.A.Macdonald,
J.J.Miles,
R.M.Brennan,
L.Kjer-Nielsen,
J.McCluskey,
S.R.Burrows,
and
J.Rossjohn
(2006).
Alloreactivity between disparate cognate and allogeneic pMHC-I complexes is the result of highly focused, peptide-dependent structural mimicry.
|
| |
J Biol Chem,
281,
34324-34332.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
K.Irvine,
and
J.Bennink
(2006).
Factors influencing immunodominance hierarchies in TCD8+ -mediated antiviral responses.
|
| |
Expert Rev Clin Immunol,
2,
135-147.
|
|
|
|
|
|
|
L.C.Sullivan,
H.L.Hoare,
J.McCluskey,
J.Rossjohn,
and
A.G.Brooks
(2006).
A structural perspective on MHC class Ib molecules in adaptive immunity.
|
| |
Trends Immunol,
27,
413-420.
|
|
|
|
|
|
|
L.K.Ely,
T.Beddoe,
C.S.Clements,
J.M.Matthews,
A.W.Purcell,
L.Kjer-Nielsen,
J.McCluskey,
and
J.Rossjohn
(2006).
Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction.
|
| |
Proc Natl Acad Sci U S A,
103,
6641-6646.
|
|
|
|
|
|
|
L.Kjer-Nielsen,
N.A.Borg,
D.G.Pellicci,
T.Beddoe,
L.Kostenko,
C.S.Clements,
N.A.Williamson,
M.J.Smyth,
G.S.Besra,
H.H.Reid,
M.Bharadwaj,
D.I.Godfrey,
J.Rossjohn,
and
J.McCluskey
(2006).
A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.
|
| |
J Exp Med,
203,
661-673.
|
|
|
PDB codes:
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|
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|
|
|
M.G.Rudolph,
R.L.Stanfield,
and
I.A.Wilson
(2006).
How TCRs bind MHCs, peptides, and coreceptors.
|
| |
Annu Rev Immunol,
24,
419-466.
|
|
|
|
|
|
|
N.A.Williamson,
J.Rossjohn,
and
A.W.Purcell
(2006).
Tumors reveal their secrets to cytotoxic T cells.
|
| |
Proc Natl Acad Sci U S A,
103,
14649-14650.
|
|
|
|
|
|
|
S.J.Turner,
P.C.Doherty,
J.McCluskey,
and
J.Rossjohn
(2006).
Structural determinants of T-cell receptor bias in immunity.
|
| |
Nat Rev Immunol,
6,
883-894.
|
|
|
|
|
|
|
S.R.Burrows,
J.Rossjohn,
and
J.McCluskey
(2006).
Have we cut ourselves too short in mapping CTL epitopes?
|
| |
Trends Immunol,
27,
11-16.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
| |
Links
