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UniProt functional annotation for P03206 | ||
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| UniProt code: P03206. |
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| Organism: | |
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus. |
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| Function: | |
Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1). {ECO:0000269|PubMed:17079287, ECO:0000269|PubMed:1847997, ECO:0000269|PubMed:19144704, ECO:0000269|PubMed:2157874, ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:8404860}. |
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| Subunit: | |
Homodimer (PubMed:28158710). Interacts with human UBN1, CRTC2 and RACK1. Interacts (via N-terminus) with human PAX5 (via N-terminus); this interaction inhibits BZLF1-mediated lytic viral reactivation (PubMed:23678172). {ECO:0000269|PubMed:10725330, ECO:0000269|PubMed:10849009, ECO:0000269|PubMed:19164291, ECO:0000269|PubMed:23678172, ECO:0000269|PubMed:28158710}. |
| Subcellular location: | |
Host nucleus {ECO:0000269|PubMed:10849009}. |
| Similarity: | |
Belongs to the bZIP family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.