spacer
spacer

PDBsum entry 1oll
Go to PDB code: 
protein ligands links
Immune system/receptor PDB id
1oll

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chain
188 a.a. *
Ligands
EDO
Waters ×136
* Residue conservation analysis
PDB id:
1oll
Name: Immune system/receptor
Title: Extracellular region of the human receptor nkp46
Structure: Nk receptor. Chain: a. Fragment: extracellular domain, residues 25-212. Synonym: isoform bnkp46 cell receptor. Engineered: yes
Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.93Å     R-factor:   0.198     R-free:   0.251
Authors: M.Ponassi,C.Cantoni,R.Biassoni,R.Conte,A.Spallarossa,A.Pesce, A.Moretta,L.Moretta,M.Bolognesi,D.Bordo
Key ref: M.Ponassi et al. (2003). Structure of the human NK cell triggering receptor NKp46 ectodomain. Biochem Biophys Res Commun, 309, 317-323. PubMed id: 12951052 DOI: 10.1016/j.bbrc.2003.08.007
Date:
07-Aug-03     Release date:   04-Sep-03    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
O76036  (NCTR1_HUMAN) -  Natural cytotoxicity triggering receptor 1 from Homo sapiens
Seq:
Struc: 		304 a.a.
188 a.a.*
Key:    Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 

 
DOI no: 10.1016/j.bbrc.2003.08.007 Biochem Biophys Res Commun 309:317-323 (2003)
PubMed id: 12951052  
 
 
Structure of the human NK cell triggering receptor NKp46 ectodomain.
M.Ponassi, C.Cantoni, R.Biassoni, R.Conte, A.Spallarossa, A.Pesce, A.Moretta, L.Moretta, M.Bolognesi, D.Bordo.
 
  ABSTRACT  
 
NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21444796 M.G.Joyce, P.Tran, M.A.Zhuravleva, J.Jaw, M.Colonna, and P.D.Sun (2011).
Crystal structure of human natural cytotoxicity receptor NKp30 and identification of its ligand binding site.
  Proc Natl Acad Sci U S A, 108, 6223-6228.  
18625238 T.I.Arnon, J.T.Kaiser, A.P.West, R.Olson, R.Diskin, B.C.Viertlboeck, T.W.Göbel, and P.J.Bjorkman (2008).
The crystal structure of CHIR-AB1: a primordial avian classical Fc receptor.
  J Mol Biol, 381, 1012-1024.
PDB code: 2vsd
16893656 T.I.Arnon, G.Markel, and O.Mandelboim (2006).
Tumor and viral recognition by natural killer cells receptors.
  Semin Cancer Biol, 16, 348-358.  
20476991 R.Biassoni, and N.Dimasi (2005).
Human natural killer cell receptor functions and their implication in diseases.
  Expert Rev Clin Immunol, 1, 405-417.  
14754506 R.Biassoni, C.Cantoni, D.Marras, J.Giron-Michel, M.Falco, L.Moretta, and N.Dimasi (2003).
Human natural killer cell receptors: insights into their molecular function and structure.
  J Cell Mol Med, 7, 376-387.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

spacer
spacer